Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells

Cancer cells mimicin vivospatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging

(2015) Shuya Yano et al.   CELL CYCLE

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

Anticancer Effects of the Nitric Oxide-Modified Saquinavir Derivative Saquinavir-NO against Multidrug-Resistant Cancer Cells

(2015) Florian Rothweiler et al.   NEOPLASIA

Tumor-targetingSalmonella typhimuriumA1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy

(2014) Shuya Yano et al.   CELL CYCLE

Invading cancer cells are predominantly in G0/G1resulting in chemoresistance demonstrated by real-time FUCCI imaging

(2014) Shuya Yano et al.   CELL CYCLE

Spatial–temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness

(2014) Shuya Yano et al.   CELL CYCLE

Targeting Mitochondria in Fighting Cancer

(2012) Vladimir Gogvadze   CURRENT PHARMACEUTICAL DESIGN

Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors

(2012) Xiaoke Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Use for an Old Drug: Inhibiting ABCG2 with Sorafenib

(2012) Y. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents

(2011) Zhi-hong Zou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Nitric Oxide-Releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Antihepatocellular Carcinoma Activity

(2011) Yong Ling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents

(2010) Yong Ling et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches

(2010) Lara Lacerda et al.   DRUG RESISTANCE UPDATES

Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO

(2010) Steven Hutchens et al.   INVESTIGATIONAL NEW DRUGS

Dynamic vs Static ABCG2 Inhibitors to Sensitize Drug Resistant Cancer Cells

(2010) Hui Peng et al.   PLoS One

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

(2009) Henk J. Broxterman et al.   DRUG RESISTANCE UPDATES

N,N-bis(Cyclohexanol)amine Aryl Esters: A New Class of Highly Potent Transporter-Dependent Multidrug Resistance Inhibitors

(2009) Cecilia Martelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid

(2009) Zhangjian Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Novel Two Mode-Acting Inhibitor of ABCG2-Mediated Multidrug Transport and Resistance in Cancer Chemotherapy

(2009) Hui Peng et al.   PLoS One

Synthesis and Cytotoxic Evaluation of Novel Dimethyl [1,1′-Biphenyl]-2,2′-dicarboxylates Bearing 1,3,4-Thiadiazole Moieties

(2008) Xiang-Wen Kong et al.   CHEMISTRY & BIODIVERSITY

Chemosensitization of Cancer by Nitric Oxide

(2008) Richard Sullivan et al.   CURRENT PHARMACEUTICAL DESIGN

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

(2008) Suneet Shukla et al.   Expert Opinion on Drug Metabolism & Toxicology

Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid

(2008) Li Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Post-translational modifications induced by nitric oxide (NO): Implication in cancer cells apoptosis

(2008) Lissbeth Leon et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases

(2008) Benjamin Bonavida et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY