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Title
How does flecainide impact RyR2 channel function?
Authors
Keywords
-
Journal
JOURNAL OF GENERAL PHYSIOLOGY
Volume 154, Issue 9, Pages -
Publisher
Rockefeller University Press
Online
2022-06-17
DOI
10.1085/jgp.202213089
References
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Related references
Note: Only part of the references are listed.- Molecular Changes in the Cardiac RyR2 With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- (2022) Angela F. Dulhunty Frontiers in Physiology
- Cardiac ryanodine receptor calcium release deficiency syndrome
- (2021) Bo Sun et al. Science Translational Medicine
- Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
- (2021) Kellie A. Woll et al. Nature Communications
- Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death
- (2021) Xiaowei Zhong et al. BIOSCIENCE REPORTS
- In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes
- (2021) Bogdan I. Iaparov et al. JOURNAL OF GENERAL PHYSIOLOGY
- Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia
- (2021) Silvia G. Priori et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action
- (2021) Samantha C. Salvage et al. Cells
- Ca2+-dependent modulation of voltage-gated myocyte sodium channels
- (2021) Samantha C. Salvage et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor
- (2021) Mark L. Bannister et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cardiac ryanodine receptors: is a severe loss-of-function not so severe after all?
- (2021) Demetrio Julián Santiago et al. EUROPACE
- Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
- (2021) Sayako Hirose et al. EUROPACE
- Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide
- (2021) Angela F. Dulhunty et al. JOURNAL OF GENERAL PHYSIOLOGY
- Cryo-EM reveals local and global structural rearrangements in RYR mutants
- (2021) Kavita A. Iyer et al. JOURNAL OF GENERAL PHYSIOLOGY
- Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome
- (2021) Julian O.M. Ormerod et al. Circulation-Genomic and Precision Medicine
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms
- (2021) Minh Tuan Hoang-Trong et al. Membranes
- Classification and correlation of RYR2 missense variants in individuals with catecholaminergic polymorphic ventricular tachycardia reveals phenotypic relationships
- (2020) Damilola Olubando et al. JOURNAL OF HUMAN GENETICS
- Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM
- (2020) Kavita A. Iyer et al. Science Advances
- Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies—Present State, Challenges, and Perspectives
- (2020) Vladena Bauerová-Hlinková et al. MOLECULES
- RYR2 Channel Inhibition Is the Principal Mechanism 0f Flecainide Action in CPVT
- (2020) Dmytro O Kryshtal et al. CIRCULATION RESEARCH
- Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse
- (2019) Samantha C. Salvage et al. JOURNAL OF CELL SCIENCE
- Interplay between triadin and calsequestrin in the pathogenesis of CPVT in mouse
- (2019) Marine Cacheux et al. MOLECULAR THERAPY
- Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload
- (2019) Hyun Seok Hwang et al. Frontiers in Physiology
- Effects of rogue ryanodine receptors on Ca 2+ sparks in cardiac myocytes
- (2018) Xudong Chen et al. Royal Society Open Science
- Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes
- (2018) Ivana Acimovic et al. Journal of Clinical Medicine
- A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia
- (2017) Yusuke Fujii et al. HEART RHYTHM
- The structural basis of ryanodine receptor ion channel function
- (2017) Gerhard Meissner JOURNAL OF GENERAL PHYSIOLOGY
- Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts
- (2017) K. Walweel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor
- (2017) Sonali Dhindwal et al. Science Signaling
- A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor
- (2017) Sonali Dhindwal et al. Science Signaling
- Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
- (2016) Mark L Bannister et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
- (2016) Wei Peng et al. SCIENCE
- Linking ryanodine receptor Ca2+leak and Na+current in heart: a day in the life of flecainide
- (2015) J. Curran et al. Acta Physiologica
- Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murineRyR2-P2328Shearts
- (2015) S. C. Salvage et al. Acta Physiologica
- The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2
- (2015) M. L. Bannister et al. CIRCULATION RESEARCH
- A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels
- (2015) L. Li et al. JOURNAL OF CELL SCIENCE
- Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
- (2015) Dario Melgari et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- In silicoprediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia
- (2015) Pei-Chi Yang et al. JOURNAL OF PHYSIOLOGY-LONDON
- The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles
- (2015) Feifei Ning et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function
- (2015) Yan-Ting Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- On the Adjacency Matrix of RyR2 Cluster Structures
- (2015) Mark A. Walker et al. PLoS Computational Biology
- Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models
- (2015) Kirsi Penttinen et al. PLoS One
- Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes
- (2015) Eleonora Savio-Galimberti et al. PLoS One
- The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca2+ Handling during Rest in Rabbit Ventricular Myocytes
- (2014) Elisa Bovo et al. BIOPHYSICAL JOURNAL
- Arrhythmogenic mechanisms in ryanodine receptor channelopathies
- (2014) Yan-Ting Zhao et al. Science China-Life Sciences
- Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia
- (2013) D. S. Steele et al. CARDIOVASCULAR RESEARCH
- Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation
- (2013) James H. King et al. CARDIOVASCULAR RESEARCH
- Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current
- (2013) Markus B. Sikkel et al. CARDIOVASCULAR RESEARCH
- Flecainide acetate for the treatment of atrial and ventricular arrhythmias
- (2013) Stavros Apostolakis et al. EXPERT OPINION ON PHARMACOTHERAPY
- Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification
- (2013) Yanmin Zhang et al. Frontiers in Physiology
- Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion
- (2012) Wen-Feng Cai et al. CARDIOVASCULAR RESEARCH
- Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output
- (2012) Angela F Dulhunty et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Calsequestrin Mutations and Catecholaminergic Polymorphic Ventricular Tachycardia
- (2012) Michela Faggioni et al. PEDIATRIC CARDIOLOGY
- Tetracaine is a Potent Inhibitor of SR Ca Leak in Ventricular Cardiac Myocytes
- (2011) Stephen Shonts BIOPHYSICAL JOURNAL
- Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca2+ Sparks
- (2011) Maura Porta et al. BIOPHYSICAL JOURNAL
- Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity
- (2011) Nian Liu et al. CIRCULATION RESEARCH
- Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia
- (2011) Hyun Seok Hwang et al. Circulation-Arrhythmia and Electrophysiology
- Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels
- (2011) Derek R. Laver et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin
- (2011) Eleonora Savio Galimberti et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Calsequestrin 2 deletion shortens the refractoriness of Ca2+ release and reduces rate-dependent Ca2+-alternans in intact mouse hearts
- (2011) Dmytro Kornyeyev et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes
- (2011) Beth A. Altschafl et al. JOURNAL OF PHYSIOLOGY-LONDON
- Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
- (2011) Christian van der Werf et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Calcium Signaling in Cardiac Myocytes
- (2011) C. J. Fearnley et al. Cold Spring Harbor Perspectives in Biology
- Ca Sparks Do Not Explain all Ryanodine Receptor-Mediated SR Ca Leak in Mouse Ventricular Myocytes
- (2010) Demetrio J. Santiago et al. BIOPHYSICAL JOURNAL
- Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts
- (2010) Yanmin Zhang et al. CARDIOVASCULAR RESEARCH
- Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model
- (2010) Shigeki Kobayashi et al. CIRCULATION JOURNAL
- In the RyR2 R4496C Mouse Model of CPVT, β-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves
- (2010) Takeshi Kashimura et al. CIRCULATION RESEARCH
- Increased Right Ventricular Repolarization Gradients Promote Arrhythmogenesis in a Murine Model of Brugada Syndrome
- (2010) CLAIRE A. MARTIN et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle
- (2009) Lan Wei et al. CELL CALCIUM
- An antidote for calcium leak: Targeting molecular arrhythmia mechanisms
- (2009) Stephan E. Lehnart et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
- (2009) Fredrick A. Hilliard et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- New roles of calsequestrin and triadin in cardiac muscle
- (2009) Björn C. Knollmann JOURNAL OF PHYSIOLOGY-LONDON
- Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
- (2009) Hiroshi Watanabe et al. NATURE MEDICINE
- Physiological consequences of theP2328Smutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts
- (2008) C. A. Goddard et al. Acta Physiologica
- Intracellular Calcium Release Channels Mediate Their Own Countercurrent: The Ryanodine Receptor Case Study
- (2008) Dirk Gillespie et al. BIOPHYSICAL JOURNAL
- Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes
- (2008) Simona Casini et al. CARDIOVASCULAR RESEARCH
- Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts
- (2008) H. Tateishi et al. CARDIOVASCULAR RESEARCH
- Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia
- (2008) María Fernández-Velasco et al. CIRCULATION RESEARCH
- How membrane proteins sense voltage
- (2008) Francisco Bezanilla NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Calcium Sparks
- (2008) Heping Cheng et al. PHYSIOLOGICAL REVIEWS
- Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels
- (2007) Christopher A. Ahern et al. CIRCULATION RESEARCH
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