Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia

Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current

(2013) Markus B. Sikkel et al.   CARDIOVASCULAR RESEARCH

Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles

(2012) Young Soo Lee et al.   HEART RHYTHM

Flecainide and Antiarrhythmic Effects in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Nian Liu et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Mechanism of Antiarrhythmic Effects of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Hiroshi Watanabe et al.   CIRCULATION RESEARCH

Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity

(2011) Nian Liu et al.   CIRCULATION RESEARCH

Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Hyun Seok Hwang et al.   Circulation-Arrhythmia and Electrophysiology

Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin

(2011) Eleonora Savio Galimberti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Christian van der Werf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

(2011) Qiang Zhou et al.   NATURE MEDICINE

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE