Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse

Ryanodine receptor Ca 2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease

(2018) Amanda Denniss et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding

(2017) Spencer J. Richardson et al.   JOURNAL OF CELL SCIENCE

Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca 2+

(2017) Peter P. Jones et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts

(2017) K. Walweel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Murine Electrophysiological Models of Cardiac Arrhythmogenesis

(2017) Christopher L.-H. Huang   PHYSIOLOGICAL REVIEWS

A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor

(2017) Sonali Dhindwal et al.   Science Signaling

A cryo-EM–based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor

(2017) Sonali Dhindwal et al.   Science Signaling

Structural Basis for Gating and Activation of RyR1

(2016) Amédée des Georges et al.   CELL

Enhanced Cytosolic Ca2+Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias

(2016) Zhichao Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murineRyR2-P2328Shearts

(2015) S. C. Salvage et al.   Acta Physiologica

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

(2015) Tetsuro Oda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles

(2015) Feifei Ning et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Dobromir Dobrev et al.   CIRCULATION RESEARCH

Cardiac ryanodine receptor activation by a high Ca 2+ store load is reversed in a reducing cytoplasmic redox environment

(2014) Amy D. Hanna et al.   JOURNAL OF CELL SCIENCE

Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+and Mg2+in the cytoplasm and in the lumen of the sarcoplasmic reticulum

(2014) Kafa Walweel et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Ryanodine Receptor Mutations Presenting as Idiopathic Ventricular Fibrillation: A Report on Two Novel Familial Compound Mutations, c.6224T>C and c.13781A>G, With the Clinical Presentation of Idiopathic Ventricular Fibrillation

(2014) Christian Paech et al.   PEDIATRIC CARDIOLOGY

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+release and destabilizes the N-terminal domains

(2013) Yingjie Liu et al.   BIOCHEMICAL JOURNAL

ATP interacts with the CPVT mutation-associated central domain of the cardiac ryanodine receptor

(2013) Lynda Blayney et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1

(2013) Alexey V. Glukhov et al.   EUROPEAN HEART JOURNAL

ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation

(2013) Jiao Li et al.   PLoS One

Atrial arrhythmia, triggering events and conduction abnormalities in isolated murineRyR2-P2328Shearts

(2012) J. H. King et al.   Acta Physiologica

Calcium Leak Through Ryanodine Receptors Leads to Atrial Fibrillation in 3 Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Jian Shan et al.   CIRCULATION RESEARCH

Prevalence of atrial fibrillation in the general population and in high-risk groups: the ECHOES study

(2012) R. C. Davis et al.   EUROPACE

Conduction Slowing Contributes to Spontaneous Ventricular Arrhythmias in Intrinsically Active MurineRyR2-P2328SHearts

(2012) YANMIN ZHANG et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart

(2012) S. Zissimopoulos et al.   JOURNAL OF CELL SCIENCE

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

(2012) Elena Galfré et al.   PLoS One

A Novel Ryanodine Receptor Mutation Linked to Sudden Death Increases Sensitivity to Cytosolic Calcium

(2011) Albano C. Meli et al.   CIRCULATION RESEARCH

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Alternans in Genetically Modified Langendorff-Perfused Murine Hearts Modeling Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Ian N. Sabir et al.   Frontiers in Physiology

The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

(2010) Ruwani Hewawasam et al.   BIOCHEMICAL PHARMACOLOGY

Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts

(2010) Yanmin Zhang et al.   CARDIOVASCULAR RESEARCH

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Ca2+-Calmodulin Increases RyR2 Open Probability yet Reduces Ryanoid Association with RyR2

(2009) Charalambos Sigalas et al.   BIOPHYSICAL JOURNAL

Physiological consequences of theP2328Smutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts

(2008) C. A. Goddard et al.   Acta Physiologica

Current concepts in the pathogenesis of atrial fibrillation

(2008) Antonios Kourliouros et al.   AMERICAN HEART JOURNAL

Sudden Death in a Young Man with Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation

(2008) STEPHEN PIZZALE et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

(2008) Stephan E. Lehnart et al.   JOURNAL OF CLINICAL INVESTIGATION