Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes

Atomic force microscopy combined with human pluripotent stem cell derived cardiomyocytes for biomechanical sensing

(2016) Martin Pesl et al.   BIOSENSORS & BIOELECTRONICS

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

(2016) Marcela K. Preininger et al.   Disease Models & Mechanisms

Translation of Human-Induced Pluripotent Stem Cells

(2016) Nazish Sayed et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

(2016) Fahima Syeda et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome

(2016) Ping Liang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia

(2016) Kenichi Sasaki et al.   PLoS One

The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2

(2015) M. L. Bannister et al.   CIRCULATION RESEARCH

Impact of CYP2D6 Genetic Variation on the Response of the Cardiovascular Patient to Carvedilol and Metoprolol

(2015) Anastasios Lymperopoulos et al.   CURRENT DRUG METABOLISM

Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: Leaky RyR2 channels under non-stress conditions

(2015) Jim W. Cheung et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Clinical utility gene card for: Catecholaminergic polymorphic ventricular tachycardia (CPVT)

(2013) Carlo Napolitano et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

(2013) Martin Pesl et al.   HEART AND VESSELS

Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture

(2013) Chengjuan Qu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

(2013) E Di Pasquale et al.   Cell Death & Disease

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Patricia Neco et al.   CIRCULATION

Calcium Leak Through Ryanodine Receptors Leads to Atrial Fibrillation in 3 Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Jian Shan et al.   CIRCULATION RESEARCH

Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells

(2012) Ilanit Itzhaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Jianwei Liu et al.   PLoS One

Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

(2012) N. Sun et al.   Science Translational Medicine

A Novel Ryanodine Receptor Mutation Linked to Sudden Death Increases Sensitivity to Cytosolic Calcium

(2011) Albano C. Meli et al.   CIRCULATION RESEARCH

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation

(2011) Atara Novak et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Christian van der Werf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

(2011) Jérémy Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Ca 2+ Sensitivity of the Ryanodine Receptor Mutant RyR2 R4496C Underlies Catecholaminergic Polymorphic Ventricular Tachycardia

(2008) María Fernández-Velasco et al.   CIRCULATION RESEARCH

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

(2008) Stephan E. Lehnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA