Orlistat Resensitizes Sorafenib-Resistance in Hepatocellular Carcinoma Cells through Modulating Metabolism

A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis

(2022) Hsing‐I Tseng et al.   Molecular Oncology

FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

(2022) Huayuan Liu et al.   Frontiers in Oncology

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

(2021) Daniela Sorriento et al.   Cells

Updated treatment recommendations for hepatocellular carcinoma (HCC) from the ESMO Clinical Practice Guidelines

(2021) A. Vogel et al.   ANNALS OF ONCOLOGY

Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model

(2021) Yeu-Sheng Tyan et al.   BIOSCIENCE REPORTS

EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma

(2021) Hoi-Wing Leung et al.   CANCER RESEARCH

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

(2021) Qiujie Wang et al.   Cell Death & Disease

Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations

(2021) Serena Stamatakos et al.   Cancers

Glycolysis and Fatty Acid Oxidation Inhibition Improves Survival in Glioblastoma

(2021) Kelly J. McKelvey et al.   Frontiers in Oncology

Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors

(2021) Xueyan Sun et al.   BIOORGANIC CHEMISTRY

Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis

(2021) Qian‐Nan Ren et al.   HEPATOLOGY

Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells

(2021) Luping Gao et al.   PLoS One

Orlistat induces ferroptosis-like cell death of lung cancer cells

(2021) Wenjing Zhou et al.   Frontiers of Medicine

Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling

(2021) Bo-Ram Jin et al.   Cells

MK8722, an AMPK activator, inhibiting carcinoma proliferation, invasion and migration in human pancreatic cancer cells

(2021) Cheng Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma

(2021) Wenbin Huang et al.   NEOPLASIA

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma

(2020) Shunjie Xia et al.   EBioMedicine

Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma

(2020) Grace K. Gifford et al.   LEUKEMIA & LYMPHOMA

Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met

(2020) Cong Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study

(2020) Sri Renukadevi Balusamy et al.   Biomed Research International

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

(2020) Moris Sangineto et al.   Cancers

Valproic acid overcomes sorafenib resistance by reducing the migration of Jagged2-mediated Notch1 signaling pathway in hepatocellular carcinoma cells

(2020) Jing Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sorafenib induces mitochondrial dysfunction and exhibits synergistic effect with cysteine depletion by promoting HCC cells ferroptosis

(2020) Yanchun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma

(2020) Haofeng Lu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Y-Box Binding Protein-1 Promotes Epithelial-Mesenchymal Transition in Sorafenib-Resistant Hepatocellular Carcinoma Cells

(2020) Li-Zhu Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

(2020) Ji-Yoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with metformin is associated with a prolonged survival in patients with hepatocellular carcinoma

(2019) Lena Schulte et al.   LIVER INTERNATIONAL

Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation

(2019) Alicia Bort et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway

(2019) Ting Lu et al.   OncoTargets and Therapy

Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway

(2019) Ge Liu et al.   FASEB JOURNAL

The Roles Of Angiogenesis And Cancer Stem Cells In Sorafenib Drug Resistance In Hepatocellular Carcinoma

(2019) Chiung-Chi Cheng et al.   OncoTargets and Therapy

Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

(2019) Hui-Yen Chuang et al.   Scientific Reports

Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine

(2019) Shangnan Dai et al.   BIOMEDICINE & PHARMACOTHERAPY

Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

(2019) Li Che et al.   Frontiers in Oncology

The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model

(2018) Efthymia Papaevangelou et al.   INTERNATIONAL JOURNAL OF CANCER

Salvia officinalis Induces Apoptosis in Mammary Carcinoma Cells Through Alteration of Bax to Bcl-2 Ratio

(2018) Sara Behroozi Moghadam et al.   Iranian Journal of Science and Technology Transaction A-Science

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

(2018) Sandra Galic et al.   eLife

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

(2018) Simon Heine et al.   Journal of Hematology & Oncology

Moringa oleifera Leaf Petroleum Ether Extract Inhibits Lipogenesis by Activating the AMPK Signaling Pathway

(2018) Jing Xie et al.   Frontiers in Pharmacology

PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC

(2017) Mi-Jin Kim et al.   MOLECULAR CANCER RESEARCH

Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells

(2017) Joshua J. Souchek et al.   MOLECULAR CANCER THERAPEUTICS

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models

(2016) Abin You et al.   Journal of Hematology & Oncology

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

(2016) Yuki Yasumoto et al.   PLoS One

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

(2014) G. Zadra et al.   EMBO Molecular Medicine

FASNating Targets of Metformin in Breast Cancer Stem-Like Cells

(2014) Elizabeth A. Wellberg et al.   Hormones & Cancer

Effects of sorafenib on energy metabolism in breast cancer cells: role of AMPK–mTORC1 signaling

(2013) Claudia Fumarola et al.   BREAST CANCER RESEARCH AND TREATMENT

SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin

(2013) D. H. Shin et al.   CANCER RESEARCH

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

The mTOR pathway in hepatic malignancies

(2013) Mamatha Bhat et al.   HEPATOLOGY

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma

(2012) Xuehua Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal

(2011) Hui-Yen Chuang et al.   BIOMEDICINE & PHARMACOTHERAPY

Field-practice study of sorafenib therapy for hepatocellular carcinoma: A prospective multicenter study in Italy

(2011) Massimo Iavarone et al.   HEPATOLOGY

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

(2010) Puspa R. Pandey et al.   BREAST CANCER RESEARCH AND TREATMENT

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells

(2009) Chi-Hung Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Fatty Acid Synthase Over Expression is an Indicator of Tumor Aggressiveness and Poor Prognosis in Renal Cell Carcinoma

(2008) Akio Horiguchi et al.   JOURNAL OF UROLOGY