Article
Food Science & Technology
Sucheewin Krobthong, Yodying Yingchutrakul, Patompon Wongtrakoongate, Hathaichanok Chuntakaruk, Thanyada Rungrotmongkol, Chartchai Chaichana, Thanisorn Mahatnirunkul, Thitikorn Chomtong, Kiattawee Choowongkomon, Chanat Aonbangkhen
Summary: Obesity is a global health concern that can be prevented by physical activities and consuming nutrient-rich functional foods. In this study, nano-liposomal encapsulated bioactive peptides (BPs) were developed to reduce cellular lipids. The nano-liposomal BPs showed potential as functional food ingredients for preventing obesity.
Review
Oncology
Qiushi Zhao, Xingyu Lin, Guan Wang
Summary: SREBP-1, a crucial transcription factor, is involved in the metabolic reprogramming of various cancers and can serve as a biomarker for prognosis or drug efficacy in cancer patients. This review discusses the structure, activation, and key upstream signaling pathways of SREBP-1, as well as its potential targets and therapeutic approaches in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jessica Nascimento, Isadora do Canto Olegario, Camila Mariot, Thayse Viana de Oliveira, Paula dos Santos Chaves, Rafaela Oliveira, Edilene Gadelha de Oliveira, Silvia Staniscuaski Guterres, Andreia Buffon, Diogo Andre Pilger, Ruy Carlos Ruver Beck
Summary: In this study, the encapsulation of orlistat (ORL) in polymeric aqueous nanocapsules (NC) was evaluated for its in vitro cytotoxic activity against cervical cancer cells. The nanoencapsulation improved the cytotoxic effect of ORL, suggesting its potential as a treatment for cervical cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hanyuan Xu, Linjie Wang, Kemin Yan, Huijuan Zhu, Hui Pan, Hongbo Yang, Meijuan Liu, Fengying Gong
Summary: The study demonstrated that nuciferine has inhibitory effects on the proliferation and differentiation of 3T3-L1 preadipocytes, possibly through downregulation of PPARγ, C/EBPα, and C/EBPβ, which in turn affects the transcription of lipogenic enzymes and lipid accumulation. Additionally, nuciferine can promote the expression of adipokines in fully differentiated adipocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
James T. F. Wise, Kazuya Kondo
Summary: The transformation of lung cells induced by hexavalent chromium leads to an increase in lipogenesis, which is crucial for the growth and cancer properties of these transformed cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jessica Nascimento, Camila Mariot, Debora R. B. Vianna, Lucia M. Kliemann, Paula S. Chaves, Massimo Loda, Andreia Buffon, Ruy C. R. Beck, Diogo A. Pilger
Summary: This study investigated the expression of Fatty acid synthase (FASN) in premalignant lesions and cervical cancer samples, as well as the effects of a FASN inhibitor on cervical cancer cells. The results showed that FASN was expressed in all cervical cancer samples and its expression increased with advanced stages of cervical cancer. The FASN inhibitor orlistat reduced the viability of cervical cancer cells in a time-dependent manner and induced apoptosis, cell cycle arrest, and autophagy.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Cell Biology
Wenting Dai, Zhichao Wang, Guan Wang, Qiong A. Wang, Ralph DeBerardinis, Lei Jiang
Summary: Fatty acid synthase is essential for lipogenesis in cancer cells, but anchorage-independent malignant cells can enhance their redox capacity through reductive carboxylation.
Article
Dentistry, Oral Surgery & Medicine
Luciana Yamamoto de Almeida, Fernanda Dos Santos Moreira, Guilherme Augusto Silva Dos Santos, Florence Juana Maria Cuadra Zelaya, Cesar Alexander Ortiz, Michelle Agostini, Flavia Sammartino Mariano, Debora Campanella Bastos, Ulisses Ribaldo Nicolau Daher, Luiz Paulo Kowalski, Ricardo D. Coletta, Edgard Graner
Summary: The study found that orlistat can increase the sensitivity of SCC-9 LN-1 cells to cisplatin and paclitaxel chemotherapy drugs by downregulating the levels of Cyclin B1. However, the inhibitory effects on proliferation, migration, and invasion of SCC-9 LN-1 cells induced by orlistat in combination with cisplatin or paclitaxel were not significantly superior to using chemotherapy drugs alone.
Article
Pharmacology & Pharmacy
Jovana Jovankic, Danijela D. Nikodijevic, Milena G. Milutinovic, Aleksandra G. Nikezic, Vesna V. Kojic, Aleksandar M. Cvetkovic, Danijela M. Cvetkovic
Summary: Breast cancer, the second leading cause of death worldwide, has prompted research into non-standard drugs for suppressing its progression. The anti-obesity drug Orlistat has shown significant effects on cancer cell metabolism, such as antiproliferative, proapoptotic, antiangiogenic, antimetastatic, and hypolipidemic effects. Evaluations of Orlistat's anticancer potential in breast cancer cells MDA-MB-231, MDA-MB-468, and MCF-7 showed significant cytotoxic, proapoptotic, and anti-angiogenic effects, while having no significant cytotoxic effects on normal cells. Orlistat also affected lipid levels and redox status parameters, and suppressed genes and proteins involved in fatty acid synthesis, making it a promising supplement for antiangiogenic therapy against breast cancer without side effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Engineering, Multidisciplinary
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
Summary: This study summarizes the findings from mouse models transgenic for the HCV genome, with a focus on the HCV core gene transgenic mice, elucidating the impact of the HCV core protein on HCC development, as well as the regulatory role of dietary habits on steatosis and hepatocarcinogenesis.
Article
Pharmacology & Pharmacy
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang
Summary: This study found that FGF9 expression was increased in the livers of diet-induced obese mice, and knockdown exacerbated the fatty liver phenotype while overexpression alleviated hepatic steatosis and improved insulin sensitivity. Mechanistically, FGF9 inhibits genes involved in lipogenesis and increases genes involved in fatty acid oxidation, reducing cellular lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiao Han, Yana Liu, Zhi Chen
Summary: In this study, LipR, a C2H2 zinc finger protein, was found to be an essential repressor of DHA and saturated fatty acid biosynthesis in Schizochytrium sp. LipR directly inhibits the transcription of PUFA synthase and fas genes through binding to a specific recognition sequence in the upstream regions of these genes. LipR also represses the expression of genes related to precursor and NADPH levels, as well as the triacylglycerol storage rate. This study provides insights into the regulatory mechanisms of DHA and lipid production in Schizochytrium sp. and suggests that manipulating the lipR gene could enhance the accumulation of polyunsaturated fatty acids and lipids in thraustochytrids.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Javier A. Menendez, Ruth Lupu
Summary: Brain metastasis (BrM) is a major contributor to morbidity and mortality in breast cancer patients. Recent studies have shown that in a lipid-deprived brain environment, breast cancer cells can generate fatty acids by upregulating fatty acid synthase (FASN) activity, which promotes their growth and metastasis in the brain. Targeting FASN and its transcriptional regulator SREBP1 presents a new therapeutic opportunity for breast cancer patients with brain metastasis.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Oncology
Michele Matta, Emily Deubler, Veronique Chajes, Beatrice Vozar, Marc J. Gunter, Neil Murphy, Mia M. Gaudet
Summary: This study found that circulating levels of fatty acids were associated with breast cancer risk, with higher levels of myristic acid showing a positive association. These findings suggest the importance of fatty acids in the development of breast cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Lin Zhu, Jianfeng Huang, Yi Wang, Zaiqing Yang, Xiaodong Chen
Summary: The study revealed the important role of chemerin in hepatic lipid metabolism, with its effects on lipid synthesis being mediated through GPR1. Free fatty acids and insulin were found to inhibit chemerin expression, while the key lipogenic transcription factor SREBP1c suppressed chemerin mRNA expression.
Article
Neurosciences
Rui Xia, Mingyue Wan, Huiying Lin, Yu Ye, Shangjie Chen, Guohua Zheng
Summary: A 6-month traditional Chinese mind-body Baduanjin exercise intervention has positive effects on cognitive ability in older people with Mild cognitive impairment (MCI) living in the community. However, the effects seem to be transient and further research is needed for confirmation.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng, Xinyan Chen
Summary: A novel multistage-targeted celastrol delivery system (C-TL/HA) was developed by electrostatic binding of hyaluronic acid (HA) to celastrol-loaded cationic liposomes. The study showed that C-TL/HA successfully delivered celastrol into mitochondria, activated apoptosis of mitochondrial pathway, and exhibited higher tumor inhibition efficiency and lower toxic side effects compared with free celastrol. The HA coating not only improved stability and safety in vivo, but also enhanced drug uptake and tumor targeting through recognition of CD44 receptors.
Article
Chemistry, Organic
Jing Liu, Baohui Zhang, Junjie Hu, Zhenpeng Qiu, Xinyan Chen, Xianxiang Tian, Qi Wang, Guohua Zheng, Ming Yuan
Summary: Here, we present an Ag+/S2O82--induced method for the synthesis of functionalized succinyl diamides with an all-carbon quaternary stereocenter via a radical aminoformylation/aryl-migration/desulfonylation cascade. This improved process utilizes oxalic monoamide, which is readily available and inexpensive, as a carbamoyl radical precursor through radical Smiles rearrangement. Additionally, the practical value of this synthesis strategy is enhanced by its tolerance to oxygen and water, operational simplicity, convenient reagents, and scalability.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yuzhen Lu, Cong Zhang, Yingying Song, Liang Chen, Xin Chen, Guohua Zheng, Yuan Yang, Peng Cao, Zhenpeng Qiu
Summary: Accumulated evidence suggests that de novo lipogenesis is a characteristic of NAFLD progression. Gallic acid (GA) is a phenolic acid with clinical significance in metabolic diseases. This study evaluated the potential of GA in treating fructose-induced NAFLD in mice. GA alleviated hepatic steatosis, oxidative stress, and inflammatory response in fructose-fed mice by restoring AMPK alpha phosphorylation and suppressing pro-lipogenic factors. The study demonstrates that GA supplementation may be a promising therapeutic strategy in NAFLD, especially in cases with enhanced hepatic lipogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Sport Sciences
Huiying Lin, Yu Ye, Mingyue Wan, Pingting Qiu, Rui Xia, Guohua Zheng
Summary: This study investigated the effects of Baduanjin exercise on cerebral hemodynamics in older adults with cognitive frailty. The results demonstrated that a 24-week Baduanjin exercise intervention could improve cerebral blood flow, enhance cognitive ability, and reduce physical frailty.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Plant Sciences
Li Li, Chuting Wang, Zhenpeng Qiu, Dongjie Deng, Xin Chen, Qi Wang, Yan Meng, Baohui Zhang, Guohua Zheng, Junjie Hu
Summary: This study revealed that triptolide suppresses the growth of ICC by inhibiting glycolysis via the AKT/mTOR pathway, offering a potential therapeutic target for ICC treatment.
Article
Agriculture, Multidisciplinary
Cong Zhang, Yingying Song, Ming Yuan, Liang Chen, Qianyu Zhang, Junjie Hu, Yan Meng, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: This study investigated the efficacy of urolithin A (UroA) in a fructose-induced NAFLD mouse model and found that UroA alleviated hepatic steatosis. Mechanistically, UroA impaired lipogenesis and enhanced fi-oxidation in the livers of fructose-fed mice by facilitating hepatic lipophagy through the AMPK/ULK1 pathway. These findings suggest that dietary supplementation of UroA or ellagitannins-rich foods may be beneficial for NAFLD individuals with high fructose intake.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Biomedical
Xuelian Wang, Hongye Cai, Xinyu Huang, Zhuhang Lu, Luxi Zhang, Junjie Hu, Daizhi Tian, Jiyu Fu, Guizhi Zhang, Yan Meng, Guohua Zheng, Cong Chang
Summary: Multidrug resistance is a major challenge in chemotherapy for non-small cell lung cancer. Mitochondria have been identified as a promising target for overcoming drug resistance. A two-stage targeted liposome was successfully developed, with paclitaxel-loaded cationic liposome formulated and further coated with hyaluronic acid. The encapsulated paclitaxel showed improved stability and safety, and the liposomes enhanced cellular uptake and accumulation of paclitaxel in mitochondria, leading to disrupted mitochondrial function, increased apoptosis, and stronger anticancer efficacy.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Integrative & Complementary Medicine
Huiying Lin, Mingyue Wan, Yu Ye, Guohua Zheng
Summary: This systematic review and meta-analysis examined the effects of Baduanjin exercise on physical function in middle-aged and older adults. The results showed that Baduanjin significantly improved muscle strength, balance ability, and cardiorespiratory fitness without any adverse events. However, more randomized controlled trials with larger sample sizes and rigorous research designs are needed in the future to confirm these findings.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Food Science & Technology
Peng Cao, Jun Gan, Sanlan Wu, Yixin Hu, Bin Xia, Xiaoyue Li, Hongan Zeng, Bingyu Cheng, Huifan Yu, Fei Li, Luqin Si, Jiangeng Huang
Summary: Tectorigenin (TG), a natural isoflavone, has protective effects on alpha-naphthylisothiocyanate-induced cholestatic liver injury by restoring abnormal markers and maintaining bile acid homeostasis through FXR-mediated bile acid efflux and Nrf2-mediated antioxidative pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peng Cao, Yi Wang, Cong Zhang, Mitchell A. Sullivan, Wen Chen, Xiang Jing, Huifan Yu, Fei Li, Qu Wang, Zhongshi Zhou, Qi Wang, Wen Tian, Zhenpeng Qiu, Lianxiang Luo
Summary: This study aims to further elucidate the potential mechanism of action of quercetin in alleviating nonalcoholic fatty liver disease (NAFLD). It was found that quercetin prevents NAFLD through AMPK-mediated mitophagy, suggesting that promoting mitophagy via an upregulation of AMPK may be a promising therapeutic strategy against NAFLD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Plant Sciences
Jun-Yu He, Jie Li, Yuan-Yuan Zhang, Hai-Bo He, Yu-Min He, Dao-Xiang Xu, Xiao Wang, Hao-Yang Wu, Ji-Hong Zhang, Hasan Jahid, Akter Sadia, Hui-Fan Yu, Jun-Zhi Wang, Kun Zou
Summary: This study demonstrates that tormentic acid (TA) has a protective effect on animals and cells with gastric damage, promoting cell proliferation and migration and improving gastric mucosal injury. Therefore, TA may be a potential clinical drug candidate for the treatment of gastric mucosal lesions.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Food Science & Technology
Peng Cao, Ming Yue, Yuanlei Cheng, Mitchell A. Sullivan, Wen Chen, Huifan Yu, Fei Li, Sanlan Wu, Yongning Lv, Xuejia Zhai, Yu Zhang
Summary: This study uses multi-omics data to elucidate the underlying mechanism of naringenin's reported benefit in alleviating non-alcoholic steatohepatitis (NASH). The intervention of naringenin significantly modulated the relative abundance of gut microbiota and the host metabolomic profile, suggesting an interplay between host serum metabolites and gut microbiota in the therapeutic effect of naringenin against NASH.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Guangwen Shu, Xiao Lei, Guangqiong Li, Tiantian Zhang, Chuo Wang, Anning Song, Huifan Yu, Xiaoming Wang, Xukun Deng
Summary: In this study, it was found that Ergothioneine (EGT) can inhibit the activation of hepatic stellate cells and alleviate liver fibrosis. EGT promotes Hint1 transcription by triggering the nuclear translocation of Foxa3, leading to the elevation of Smad7.