ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma

Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer

(2021) Jihui Chen et al.   Cancer Cell International

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

(2020) Yanwei Su et al.   CANCER LETTERS

miR-552 Regulates Liver Tumor-Initiating Cell Expansion and Sorafenib Resistance

(2020) Tao Han et al.   Molecular Therapy-Nucleic Acids

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

(2019) Kevin Leandro et al.   PHARMACOLOGICAL RESEARCH

Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish

(2019) Hui Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

(2018) Si-tong Li et al.   ACTA PHARMACOLOGICA SINICA

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Regulation mechanism of oxidative stress induced by high glucose through PI3K/Akt/Nrf2 pathway in juvenile blunt snout bream ( Megalobrama amblycephala )

(2017) Wenjing Pan et al.   FISH & SHELLFISH IMMUNOLOGY

Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012

(2017) Donna L. White et al.   GASTROENTEROLOGY

Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter

(2017) Jia Ding et al.   LABORATORY INVESTIGATION

Ferroptosis: process and function

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Biology, Epidemiology, Clinical Aspects of Hepatocellular Carcinoma and the Role of Sorafenib

(2016) Gianluigi Mazzoccoli et al.   CURRENT DRUG TARGETS

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma

(2016) Tetsu Tomonari et al.   Oncotarget

PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression

(2015) Tao Luo et al.   Autophagy

MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks

(2015) Wenbin Li et al.   DRUG METABOLISM REVIEWS

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs

(2015) Robert S. Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib

(2014) Maria Reig et al.   JOURNAL OF HEPATOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine

(2014) Auke D Adema et al.   SpringerPlus

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity

(2012) Kuen-Feng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multidrug Resistance Protein 2 Implicates Anticancer Drug-Resistance to Sorafenib

(2011) Yoshihiko Shibayama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitrostudy

(2009) Zhe Zhang et al.   BMC Medicine