Cell Autophagy in NASH and NASH-Related Hepatocellular Carcinoma

Tumor-Suppressor Role of the α1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma

(2022) Utibe-Abasi S. Udoh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective autophagy as a therapeutic target for neurological diseases

(2020) Weilin Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of class I PI3K enhances chaperone-mediated autophagy

(2020) S. Joseph Endicott et al.   JOURNAL OF CELL BIOLOGY

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

(2019) Po-Yuan Ke   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

(2019) Rekha Khandia et al.   Cells

Recent Insights Into the Multiple Pathways Driving Non-alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma

(2019) Kazuki Takakura et al.   Frontiers in Oncology

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

(2019) Jasmin A Schäfer et al.   EMBO JOURNAL

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma

(2018) Ozlem Kutlu et al.   Canadian Journal of Gastroenterology and Hepatology

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

(2018) Brian N. Finck   DIABETES

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Evidence for ESCRT- and clathrin-dependent microautophagy

(2017) Masahide Oku et al.   JOURNAL OF CELL BIOLOGY

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma

(2017) Srinivas Chava et al.   Oncotarget

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer

(2016) Jinfeng Zhou et al.   Autophagy

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats

(2016) Maria Xilouri et al.   Autophagy

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Function of Autophagy in Nonalcoholic Fatty Liver Disease

(2016) Mark J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation

(2016) D. T. Reid et al.   PLoS One

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

(2015) Wei Xie et al.   Autophagy

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

(2015) Caroline Park et al.   Nature Communications

PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis

(2015) Wenjie Zhang et al.   Oncotarget

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization

(2014) Li Zhang et al.   Autophagy

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Autophagy: A novel therapeutic target for hepatocarcinoma (Review)

(2014) ZHANGGUI WANG et al.   Oncology Letters

Autophagy and Non-Alcoholic Fatty Liver Disease

(2014) Vanessa J. Lavallard et al.   Biomed Research International

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Autophagy in the liver

(2013) Patrice Codogno et al.   JOURNAL OF HEPATOLOGY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy

(2012) Tapas Saha   Autophagy

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

(2012) Julia Romanov et al.   EMBO JOURNAL

Liver autophagy: physiology and pathology

(2012) M. Komatsu   JOURNAL OF BIOCHEMISTRY

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis

(2011) CECILIA SÖDERBERG et al.   APMIS

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

(2011) Mark J. Czaja   GASTROENTEROLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Role of Chaperone Mediated Autophagy (CMA) in the Degradation of Misfolded N-CoR Protein in Non-Small Cell Lung Cancer (NSCLC) Cells

(2011) Azhar Bin Ali et al.   PLoS One

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy

(2010) Te-Ling Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Epidemiology of Non-Alcoholic Fatty Liver Disease

(2010) Stefano Bellentani et al.   DIGESTIVE DISEASES

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone-mediated autophagy is defective in mucolipidosis type IV

(2009) Bhuvarahamurthy Venugopal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches

(2009) Shoichi Takikita et al.   MOLECULAR GENETICS AND METABOLISM

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Chaperone-mediated autophagy: selectivity pays off

(2009) Ana Maria Cuervo   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autophagy: Principles and significance in health and disease

(2008) Virginia Todde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma

(2008) Z.-B. Ding et al.   CANCER RESEARCH

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE