Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma

Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy

(2018) Derek J. Erstad et al.   CANCER

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

(2018) Antonella Borrelli et al.   Redox Biology

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma

(2017) Ayesha Khalid et al.   TUMOR BIOLOGY

Implication of the Hedgehog pathway in hepatocellular carcinoma

(2017) Carminia Maria Della Corte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma

(2017) Sufang Yang et al.   Oncology Letters

CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice

(2017) Yongzhen Liu et al.   Scientific Reports

Plasma Adiponectin and Hepatocellular Carcinoma Survival Among Patients Without Liver Transplantation

(2016) JING SHEN et al.   ANTICANCER RESEARCH

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

(2016) Perinur Bozaykut et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease

(2015) Hae-Ki Min et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adiponectin induces apoptosis in hepatocellular carcinoma through differential modulation of thioredoxin proteins

(2015) Su-Qian Xing et al.   BIOCHEMICAL PHARMACOLOGY

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma: A Growing Epidemic?

(2015) Adam C. Yopp et al.   DIGESTIVE DISEASES

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity

(2015) Alison Mondul et al.   JOURNAL OF NUTRITION

The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment

(2015) Cristina Margini et al.   LIVER INTERNATIONAL

Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma

(2015) Hamza Chettouh et al.   LIVER INTERNATIONAL

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Identification of Hepatocellular Carcinoma-associated Hub Genes and Pathways by Integrated Microarray Analysis

(2015) Fangfeng Liu et al.   TUMORI

Identification of Hepatocellular Carcinoma-associated Hub Genes and Pathways by Integrated Microarray Analysis

(2015) Fangfeng Liu et al.   TUMORI JOURNAL

Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing

(2015) Filip Janku et al.   Oncotarget

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Silencing ofmicroRNA-122is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis

(2014) Yoko Takaki et al.   CANCER SCIENCE

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

(2014) William Peverill et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding

(2014) Brittany V. Martin-Murphy et al.   PLoS One

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Leptin signaling molecular actions and drug target in hepatocellular carcinoma

(2014) Qing Sun et al.   Drug Design Development and Therapy

Immunomodulation by Gut Microbiota: Role of Toll-Like Receptor Expressed by T Cells

(2014) Mariagrazia Valentini et al.   Journal of Immunology Research

Involvement of free radicals and oxidative stress in NAFLD/NASH

(2013) Y. Sumida et al.   FREE RADICAL RESEARCH

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

(2013) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Role of the Hedgehog pathway in hepatocellular carcinoma (Review)

(2013) XIN ZHENG et al.   ONCOLOGY REPORTS

PNPLA3 I148M polymorphism and progressive liver disease

(2013) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

Immunological functions of leptin and adiponectin

(2012) Fortunata Carbone et al.   BIOCHIMIE

Cell cycle-related kinase links androgen receptor and β-catenin signaling in hepatocellular carcinoma: Why are men at a loss?

(2012) Prince K. Awuah et al.   HEPATOLOGY

Natural killer cells in liver disease

(2012) Zhigang Tian et al.   HEPATOLOGY

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway

(2011) Yotaro Kudo et al.   JOURNAL OF HEPATOLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

(2010) Maria Norlin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Decreased expression of XPO4 is associated with poor prognosis in hepatocellular carcinoma

(2010) Xiao-ting Liang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet

(2010) Volodymyr P. Tryndyak et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor

(2008) Hung-Yun Lin et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

(2008) Christopher L. Gentile et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis

(2008) M. Nannipieri et al.   OBESITY SURGERY