MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
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Title
MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
Authors
Keywords
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Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 108, Issue -, Pages 108863
Publisher
Elsevier BV
Online
2022-05-25
DOI
10.1016/j.intimp.2022.108863
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Note: Only part of the references are listed.- Enhanced CXCL12/CXCR4 signaling increases tumor progression in radiation‑resistant pancreatic cancer
- (2022) Tomokatsu Kato et al. ONCOLOGY REPORTS
- CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment
- (2022) Cesarina Giallongo et al. Oncogenesis
- Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung
- (2021) Jiarong Li et al. ENDOCRINOLOGY
- A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
- (2021) Jen-Shin Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization
- (2021) Cheng Tang et al. Cell Death & Disease
- Tumor-Associated Macrophage Promotes the Survival of Cancer Cells upon Docetaxel Chemotherapy via the CSF1/CSF1R–CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer
- (2021) Wei Guan et al. Genes
- Motixafortide and Pembrolizumab Combined to Nanoliposomal Irinotecan, Fluorouracil, and Folinic Acid in Metastatic Pancreatic Cancer: The COMBAT/KEYNOTE-202 Trial
- (2021) Bruno Bockorny et al. CLINICAL CANCER RESEARCH
- Overexpression of chemokine receptor CXCR4 predicts lymph node metastatic risk in patients with melanoma: A systematic review and meta-analysis
- (2021) Mina Alimohammadi et al. CYTOKINE
- Tumor Microenvironment
- (2020) Borros Arneth Medicina-Lithuania
- Small molecules, big impact: 20 years of targeted therapy in oncology
- (2020) Philippe L Bedard et al. LANCET
- BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
- (2020) Bruno Bockorny et al. NATURE MEDICINE
- Chloroquine Inhibits Stemness of Esophageal Squamous Cell Carcinoma Cells Through Targeting CXCR4-STAT3 Pathway
- (2020) Dongli Yue et al. Frontiers in Oncology
- Cancer-Associated Fibroblasts in Mycosis Fungoides Promote Tumor Cell Migration and Drug Resistance via CXCL12/CXCR4
- (2020) Anna Aronovich et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Novel CXCR4 Inhibitor CPZ1344 Inhibits the Proliferation, Migration and Angiogenesis of Glioblastoma
- (2020) Zhengxiang Luo et al. PATHOLOGY & ONCOLOGY RESEARCH
- Leptin promotes bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis
- (2020) Lixia Duan et al. Aging-US
- The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting
- (2020) Martine J. Smit et al. Annual Review of Pharmacology and Toxicology
- CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent
- (2020) Jingzhe Wang et al. PHARMACOLOGICAL RESEARCH
- The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration
- (2020) Marco E. Bianchi et al. Frontiers in Immunology
- Involvement of CXCR4 in Normal and Abnormal Development
- (2019) Nanako Kawaguchi et al. Cells
- ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin
- (2019) Friederike Saaber et al. Cell Reports
- GENESIS: Phase III trial evaluating BL-8040 + G-CSF to mobilize hematopoietic cells for autologous transplant in myeloma
- (2019) Zachary D Crees et al. Future Oncology
- Modulators of CXCR4 and CXCR7/ACKR3 function
- (2019) Ilze Adlere et al. MOLECULAR PHARMACOLOGY
- Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow
- (2019) Ryo Takahashi et al. BIOMEDICINE & PHARMACOTHERAPY
- Discovery of small-molecule candidates against inflammatory bowel disease
- (2019) Renren Bai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
- (2019) Ashraf Mousavi IMMUNOLOGY LETTERS
- Nanobodies and Cancer: Current Status and New Perspectives
- (2018) Alessandro Allegra et al. CANCER INVESTIGATION
- Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases
- (2018) Ilaria Roato et al. Cancers
- Advances in Molecular Mechanisms and Treatment of Radiation-Induced Pulmonary Fibrosis
- (2018) Zhongjie Chen et al. Translational Oncology
- Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
- (2017) Wei Xiao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
- (2017) Manoj K. Kashyap et al. Journal of Hematology & Oncology
- ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet–associated Colon Cancer
- (2016) Reba Mustafi et al. CLINICAL CANCER RESEARCH
- Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma
- (2016) Federica Barbieri et al. Expert Opinion on Drug Discovery
- New agents in HSC mobilization
- (2016) Mélanie J. Domingues et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4
- (2016) Katherine Griffiths et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis
- (2016) M. Katie Conley-LaComb et al. Molecular Cancer
- A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells
- (2016) M. Broussas et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies
- (2016) Sheng-Bin Peng et al. PLoS One
- Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell
- (2016) Zhidong Wang et al. TUMOR BIOLOGY
- Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence
- (2016) Anna Julie Peired et al. Stem Cells International
- Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment
- (2015) S. Scala CLINICAL CANCER RESEARCH
- LFC131 peptide-conjugated polymeric nanoparticles for the effective delivery of docetaxel in CXCR4 overexpressed lung cancer cells
- (2015) Ruo-Tian Wang et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4
- (2015) Martin Schwickart et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- The Chemokine Receptors CXCR4/CXCR7 and Their Primary Heterodimeric Ligands CXCL12 and CXCL12/High Mobility Group Box 1 in Pancreatic Cancer Growth and Development
- (2015) Murtaza Shakir et al. PANCREAS
- POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL
- (2015) Edward Allan R. Sison et al. Oncotarget
- Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression
- (2014) Zhongxing Liang et al. BREAST CANCER RESEARCH AND TREATMENT
- 351 hz515H7, a humanized antibody exerts its antitumor activity via antagonism of the CXCR4/SDF-1 axis, and through effector functions
- (2014) C. Klinguer-Hamour et al. EUROPEAN JOURNAL OF CANCER
- CXCR4 as biomarker for radioresistant cancer stem cells
- (2014) Franziska Trautmann et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- CXCR4 antagonist inhibits perineural invasion of adenoid cystic carcinoma
- (2014) Woo-Jin Jeong et al. JOURNAL OF CLINICAL PATHOLOGY
- MiR-451 Suppresses Cell Proliferation and Metastasis in A549 Lung Cancer Cells
- (2014) Pin Yin et al. MOLECULAR BIOTECHNOLOGY
- MicroRNAs in cancer: biomarkers, functions and therapy
- (2014) Josie Hayes et al. TRENDS IN MOLECULAR MEDICINE
- CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells
- (2014) C Ieranò et al. Cell Death & Disease
- Inhibition of CXCR4–CXCL12 chemotaxis in melanoma by AMD11070
- (2013) G O'Boyle et al. BRITISH JOURNAL OF CANCER
- IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells
- (2013) Mingmin Wang et al. CANCER BIOLOGY & THERAPY
- Fragment-Based Optimization of Small Molecule CXCL12 Inhibitors for Antagonizing the CXCL12/CXCR4 Interaction
- (2013) Joshua J. Ziarek et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- The role of the CXCL12-CXCR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)
- (2013) YU-XIN LIAO et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- CXCR4-Targeted Therapy Inhibits VEGF Expression and Chondrosarcoma Angiogenesis and Metastasis
- (2013) X. Sun et al. MOLECULAR CANCER THERAPEUTICS
- MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway
- (2013) T Yu et al. ONCOGENE
- Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases
- (2013) Luigi Portella et al. PLoS One
- Inhibition of the CXCL12/CXCR4-Axis as Preventive Therapy for Radiation-Induced Pulmonary Fibrosis
- (2013) Hui-Kuo G. Shu et al. PLoS One
- Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease
- (2013) Lael Werner et al. Theranostics
- Small Molecule Inhibitors of CXCR4
- (2013) Bikash Debnath et al. Theranostics
- Halting metastasis through CXCR4 inhibition
- (2012) Deborah M. Ramsey et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Mesenchymal stem cell signaling in cancer progression
- (2012) Anja Torsvik et al. CANCER TREATMENT REVIEWS
- A review on CXCR4/CXCL12 axis in oncology: No place to hide
- (2012) Urszula M. Domanska et al. EUROPEAN JOURNAL OF CANCER
- Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016
- (2012) Yasushi Otani et al. FEBS LETTERS
- The emerging role of CXC chemokines and their receptors in cancer
- (2012) Victoria Vinader et al. Future Medicinal Chemistry
- Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells
- (2012) Eileen L Heinrich et al. Journal of Translational Medicine
- Single oral administration of the novel CXCR4 antagonist, KRH-3955, induces an efficient and long-lasting increase of white blood cell count in normal macaques, and prevents CD4 depletion in SHIV-infected macaques: a preliminary study
- (2012) Tadashi Nakasone et al. MEDICAL MICROBIOLOGY AND IMMUNOLOGY
- Development of a Unique Small Molecule Modulator of CXCR4
- (2012) Zhongxing Liang et al. PLoS One
- CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges
- (2012) Filomena de Nigris et al. Recent Patents on Anti-Cancer Drug Discovery
- Touch of Chemokines
- (2012) Xavier Blanchet et al. Frontiers in Immunology
- Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness
- (2011) Elisa Giannoni et al. ANTIOXIDANTS & REDOX SIGNALING
- SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF
- (2011) Paul T. Schumacker CANCER CELL
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer
- (2011) E. Righi et al. CANCER RESEARCH
- CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration
- (2011) Fabien M. Décaillot et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Imaging CXCR4 Expression in Human Cancer Xenografts: Evaluation of Monocyclam 64Cu-AMD3465
- (2011) R. A. De Silva et al. JOURNAL OF NUCLEAR MEDICINE
- MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias
- (2011) I Spinello et al. Blood Cancer Journal
- CXCR4-Mediated Bone Marrow Progenitor Cell Maintenance and Mobilization Are Modulated by c-kit Activity
- (2010) Min Cheng et al. CIRCULATION RESEARCH
- CXCL12 (SDF-1)/CXCR4 Pathway in Cancer
- (2010) B. A. Teicher et al. CLINICAL CANCER RESEARCH
- Update on clinical experience with AMD3100, an SDF-1/CXCL12–CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cells
- (2010) Iskra Pusic et al. CURRENT OPINION IN HEMATOLOGY
- The role of SDF-1/CXCR4 axis in ovarian cancer metastasis
- (2010) Xiaoyan Shen et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
- (2010) B. Wu et al. SCIENCE
- Recent patents regarding the discovery of small molecule CXCR4antagonists
- (2009) Cara A Mosley et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-κB-dependent pathways
- (2009) Chun-Yin Huang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF- B pathways and promotes osteoclastogenesis in human oral cancer cells
- (2008) C.-H. Tang et al. CARCINOGENESIS
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