The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration

Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

(2020) Bryan S. Stephens et al.   Science Signaling

Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy

(2020) Dina Morein et al.   Frontiers in Immunology

A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

(2019) Soumyashree Das et al.   CELL

Evolving complexity of MIF signaling

(2019) Stanislovas S. Jankauskas et al.   CELLULAR SIGNALLING

CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

(2019) Alessandra Righetti et al.   Journal of Oncology

Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling

(2019) Jiachi Ma et al.   Cell Communication and Signaling

Diflunisal targets the HMGB 1/ CXCL 12 heterocomplex and blocks immune cell recruitment

(2019) Federica De Leo et al.   EMBO REPORTS

Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation

(2019) Rubén Marín-Juez et al.   DEVELOPMENTAL CELL

A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage

(2019) Giulia Zanetti et al.   Annals of Clinical and Translational Neurology

Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function

(2018) Laura Martínez-Muñoz et al.   MOLECULAR CELL

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert

(2018) Geoffrey Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4

(2018) Michael Lacy et al.   Scientific Reports

Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4

(2018) Stephanie L.C. Scofield et al.   LIFE SCIENCES

High mobility group box 1 orchestrates tissue regeneration via CXCR4

(2017) Mario Tirone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells

(2017) Shih-Yin Ho et al.   Stem Cells International

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions

(2016) Deepa Rajasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells

(2016) Lijun Zhang et al.   NEUROSCIENCE

Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists

(2016) Rama K. Mishra et al.   Scientific Reports

NF-κB oscillations translate into functionally related patterns of gene expression

(2016) Samuel Zambrano et al.   eLife

Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration

(2015) Shahin Rafii et al.   NATURE CELL BIOLOGY

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

CXCL12-CXCR4 Axis Promotes Proliferation, Migration, Invasion, and Metastasis of Ovarian Cancer

(2015) Qing Guo et al.   ONCOLOGY RESEARCH

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

MicroRNA-150 Protects the Heart From Injury by Inhibiting Monocyte Accumulation in a Mouse Model of Acute Myocardial InfarctionCLINICAL PERSPECTIVE

(2014) Zheng Liu et al.   Circulation-Cardiovascular Genetics

Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma

(2014) Xin-Yu Tan et al.   Gut and Liver

Chemotactic Responses of Neural Stem Cells to SDF-1α Correlate Closely with Their Differentiation Status

(2014) Yebing Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

The CXCR4/SDF1 Axis Improves Muscle Regeneration Through MMP-10 Activity

(2014) Miriam Bobadilla et al.   STEM CELLS AND DEVELOPMENT

Modulation of the CXC Chemokine Receptor 4 Agonist Activity of Ubiquitin through C-Terminal Protein Modification

(2013) Abhishek Tripathi et al.   BIOCHEMISTRY

miR-9 targets CXCR4 and functions as a potential tumor suppressor in nasopharyngeal carcinoma

(2013) Juan Lu et al.   CARCINOGENESIS

CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

(2013) Wei Mo et al.   CELL

MicroRNA-126 functions as a tumor suppressor in colorectal cancer cells by targeting CXCR4 via the AKT and ERK1/2 signaling pathways

(2013) YALING LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/β-catenin signaling pathway

(2013) T Yu et al.   ONCOGENE

Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model

(2013) M. Toritsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXC Chemokine Receptor 4 is Essential for Maintenance of Renal cell Carcinoma-Initiating Cells and Predicts Metastasis

(2013) Maximilian Gassenmaier et al.   STEM CELLS

Effects of CXCR4 gene silencing by lentivirus shRNA on proliferation of the EC9706 human esophageal carcinoma cell line

(2013) Dao-feng Wang et al.   TUMOR BIOLOGY

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA

(2013) Virginie Dormoy-Raclet et al.   Nature Communications

β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis

(2012) Sang-Hyun Lee et al.   GLIA

Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells

(2012) Guang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells

(2012) M-J Jung et al.   ONCOGENE

CXCR4 Expression in Prostate Cancer Progenitor Cells

(2012) Anna Dubrovska et al.   PLoS One

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiR-1 Is a Tumor Suppressor in Thyroid Carcinogenesis Targeting CCND2, CXCR4, and SDF-1α

(2011) Vincenza Leone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: Role in non–small cell lung cancer tumor proliferation

(2011) Ori Wald et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias

(2011) I Spinello et al.   Blood Cancer Journal

Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells

(2010) Meizhang Li et al.   GLIA

CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin

(2010) Vikas Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma

(2010) Tong Li et al.   JOURNAL OF PATHOLOGY

Pancreatic Stellate Cells Increase the Invasion of Human Pancreatic Cancer Cells through the Stromal Cell-Derived Factor-1/CXCR4 Axis

(2010) Zhenjun Gao et al.   PANCREATOLOGY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1α-mediated stellate cell activation

(2009) Feng Hong et al.   HEPATOLOGY

CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway

(2009) Yumei Wu et al.   JOURNAL OF NEUROCHEMISTRY

A Chemokine Targets the Nucleus: Cxcl12-Gamma Isoform Localizes to the Nucleolus in Adult Mouse Heart

(2009) Raul Torres et al.   PLoS One

Complement-Derived Anaphylatoxin C3a Regulates In Vitro Differentiation and Migration of Neural Progenitor Cells

(2009) Noriko Shinjyo et al.   STEM CELLS

The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia

(2008) R M Thomas et al.   GUT

Chemokine signaling in cancer: One hump or two?

(2008) Joshua B. Rubin   SEMINARS IN CANCER BIOLOGY