Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Lun-Yin Chou, Chun-Te Ho, Shih-Chieh Hung
Summary: This study reveals that late MSCs display senescence features and that proinflammatory cytokines from late MSCs contribute to the cellular senescence of early MSCs via paracrine signaling, ultimately impairing their functionality.
Article
Biochemistry & Molecular Biology
Jisu Jeon, Yeji Lee, Hyeonseung Yu, Unhwan Ha
Summary: The study found that Pseudomonas aeruginosa DnaK induces production of Pentraxin 3, mediated through intracellular signals transmitted by the Toll-like receptor 4 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai
Summary: This study found that Vindoline (Vin) extracted from Catharanthus roseus can suppress the progression of osteoarthritis (OA) by inhibiting osteoclastogenesis and stabilizing the extracellular matrix (ECM) of articular cartilage. This provides molecular-level evidence for the potential of Vin in the treatment of OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yanran Huang, Zhou Xie, Habu Jiwa, Jun Zhang, Yuping Wang, Jingtao Xu, Xiaoji Luo
Summary: This study evaluated the effects and mechanism of Asiatic acid (AA) on osteosarcoma (OS) cells. The results showed that AA inhibited cell proliferation, migration, and invasion, as well as induced apoptosis and cell cycle arrest in vitro. In vivo experiments also demonstrated that AA inhibited OS growth and lung metastasis in mice. Further analysis suggested that AA may exert its effects by inhibiting the PI3K/AKT and NF-kappa B signaling pathways. These findings provide important insights for the clinical application and development of AA.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Multidisciplinary
Ming-Yu Jin, Xiao-Yong Wu, Mei-Ying Li, Xiao-Tong Li, Ri-Ming Huang, Yuan-Ming Sun, Zhen-Lin Xu
Summary: Noni fruit polysaccharides (NFP) exhibit anti-inflammatory effects in a DSS-induced IBD mouse model by regulating intestinal microecological balance and inhibiting inflammatory signaling pathways. NFP upregulates beneficial acids and downregulates harmful acids, suggesting its potential as a cost-effective intervention for preventing and treating IBD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Huakun Huang, Qiuping Lu, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo
Summary: Andrographolide (AG) inhibits the proliferation and migration of osteosarcoma cells, promotes apoptosis, and suppresses tumor growth and lung metastasis. It affects multiple signaling pathways. AG may be a promising candidate for the treatment of osteosarcoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Panpan Chen, Rong Wang, Fangbin Liu, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan
Summary: Schizandrin C from Schisandra chinensis has been found to ameliorate liver fibrosis by regulating lipid metabolism and inflammation through nuclear factor kappa-B and p38/ERK MAPK signaling pathways, making it a potential drug for liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Lilly M. Wong, Guochun Jiang
Summary: HIV cure is hindered by the presence of quiescent yet replication competent HIV-1, but current research in NF-kappa B signaling pathways shows promise. Both canonical and noncanonical NF-kappa B signaling have been found to promote latency reversal and expression of HIV from reservoirs, offering new avenues for potential functional cure strategies.
Article
Pharmacology & Pharmacy
Yue Zhang, Yulong Li, Jinxi Zhang, Xue Qi, Yuan Cui, Kai Yin, Hongjin Lin
Summary: This study revealed that cadmium exposure caused inflammation and apoptosis in epididymal tissues. The activation of the RAF1/MEK/ERK pathway and subsequent up-regulation of NF-kappa B played a crucial role in these processes. This research provides valuable insights into the reproductive toxicity of cadmium.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Oncology
Chi-huan LI, Ming-chou Ku, Kun-ching Lee, Po -fu Yueh, Fei-ting Hsu, Rong-fong Lin, Chung-chi Yang, Wei-chun Wang, Jiann-hwa Chen, Li-cho Hsu, Yuan-hao Lee
Summary: Magnolol may exert cytotoxic effects on osteosarcoma cells and inhibit tumor progression by regulating apoptosis and oncogene expression.
ANTICANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yamei Liu, Binlan Fu, Xiaoman Li, Chen Chen, Xican Li, Liangliang Xu, Bin Wang
Summary: This study investigated the effect of Bushen Huoxue decoction (BHD) on RANKL-induced osteoclastogenesis and its underlying mechanisms. The results showed that BHD inhibited osteoclast formation through the attenuation of NF-kappa B, ERK, and JNK signaling. Additionally, BHD was found to have therapeutic effects on glucocorticoid-induced osteoporosis (GIOP) by repressing osteoclast activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xiaolong Yu, Jiawei Hu, Xinming Yang, Qiang Xu, Hangjun Chen, Ping Zhan, Bin Zhang
Summary: Sesamin has been found to inhibit osteoclast activation and bone resorption by blocking signaling pathways, making it a promising phytochemical agent for the treatment of osteolysis-related diseases caused by inflammation and excessive osteoclast activation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Fan Yang, Yuangang Su, Jiamin Liang, Keyi Wang, Haoyu Lian, Junchun Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: Postmenopausal osteoporosis is a chronic metabolic disease characterized by low bone mineral density and bone fragility. In this study, it was found that Casticin inhibits osteoclast activation and differentiation induced by the receptor activator of nuclear factor-κB ligand. Casticin also prevents bone loss and reduces osteoclast activity in vivo, suggesting its potential as a preventive treatment for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu, Feng Xu
Summary: The study demonstrates that PRI has therapeutic potential in treating osteolytic diseases like osteoporosis by inhibiting osteoclast formation and bone resorption activity both in vitro and in vivo. PRI exerts its effects through the suppression of NF-κB and ERK MAPK signaling pathways, preventing the production of mature osteoclasts.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Environmental Sciences
Jing-Yang Huang, Shun-Fa Yang, Pei-Ju Wu, Chun-Hao Wang, Chih-Hsin Tang, Po-Hui Wang
Summary: A nationwide population cohort research compared the risk of ovarian cancer in patients with endometriosis or pelvic inflammatory disease (PID), finding that patients with endometriosis were more likely to develop ovarian cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Huey-En Tzeng, Syuan-Ling Lin, Louis-Anoop Thadevoos, Chih-Yuan Ko, Ju-Fang Liu, Yu-Wen Huang, Chih-Yang Lin, Yi-Chin Fong, Chih-Hsin Tang
Summary: Chondrosarcoma is a common tumor with high metastatic potential, and NGF can promote its migration and metastasis by inhibiting miR-423-5p expression to induce MMP-2 synthesis and cell motility, making NGF a potential therapeutic target for metastatic chondrosarcoma.
Article
Cell Biology
Chien-Chung Huang, Tzu-Ting Tseng, Shan-Chi Liu, Yen-You Lin, Yat-Yin Law, Sung-Lin Hu, Shih-Wei Wang, Chun-Hao Tsai, Chih-Hsin Tang
Summary: Angiogenesis and S1P play crucial roles in the pathogenesis of RA, with S1P treatment promoting VEGF production and angiogenesis. Infection with SphK1 shRNA can reduce angiogenesis and joint swelling, indicating the therapeutic potential of S1P in RA treatment.
Article
Biochemistry & Molecular Biology
Hsiao-Chi Tsai, Yan-You Lai, Hsuan-Chih Hsu, Yi-Chin Fong, Ming-Yu Lien, Chih-Hsin Tang
Summary: This study implicates CCL4 as a potential target for treating metastatic osteosarcoma, as it promotes the expression of integrin αvβ3 and cell migration. The correlation between CCL4 and integrin αvβ3 expression with osteosarcoma clinical stages and lung metastasis was positive.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chi Lu, Hsiao-Chi Tsai, Dong-Ying Yang, Shih-Wei Wang, Ming-Hsui Tsai, Chun-Hung Hua, Kwei-Jing Chen, Michael Yuan-Chien Chen, Ming-Yu Lien, Chih-Hsin Tang
Summary: The inflammatory chemokine CCL4 promotes angiogenesis and metastasis in oral squamous cell carcinoma (OSCC) by upregulating Angpt2 expression and activating MEK, ERK, and STAT3 signaling pathways. Inhibiting CCL4 may be a potential strategy for treating OSCC by targeting angiogenesis and metastasis.
Article
Cell Biology
Tien-Huang Lin, Sunny Li-Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan-Chi Liu, Hsiao-Chi Tsai, An-Chen Chang, Jo-Yu Lin, Po-Chun Chen, Ju-Fang Liu, Jeng-Hung Guo, Chun-Lin Liu, Hsi-Chin Wu, Chih-Hsin Tang
Summary: Apelin plays a positive role in prostate cancer metastasis and is positively correlated with tumor progression and metastasis. It promotes cell migration and invasion by inhibiting TIMP2 expression. The signaling pathway of c-Src/PI3K/Akt and the synthesis of miR-106a-5p are controlled by apelin to regulate TIMP2 production and cell motility. Blocking apelin can inhibit prostate cancer metastasis in a mouse model.
Article
Cell Biology
Chang-Yu Song, Sunny Li-Yun Chang, Chih-Yang Lin, Chun-Hao Tsai, Shang-Yu Yang, Yi-Chin Fong, Yu-Wen Huang, Shih-Wei Wang, Wei-Cheng Chen, Chih-Hsin Tang
Summary: New treatments for chondrosarcoma are crucial due to its poor prognosis, and factors like PDGF and visfatin play significant roles in tumor development and angiogenesis. Research has shown that visfatin promotes chondrosarcoma angiogenesis by modulating miR-1264 expression, potentially offering a new therapeutic approach for the treatment of chondrosarcoma.
Article
Biochemistry & Molecular Biology
Sheng-Yen Hsiao, Chih-Hsin Tang, Po-Chun Chen, Tien-Huang Lin, Chia-Chia Chao
Summary: Melatonin exhibits antitumor activities against bladder cancer by inhibiting the epithelial-mesenchymal transition process and autophagy of bladder cancer cells. Melatonin treatment also slightly prolongs the survival of tumor-bearing mice.
Article
Cell Biology
Trung-Loc Ho, Chih-Hsin Tang, Sunny Li-Yun Chang, Chun-Hao Tsai, Hsien-Te Chen, Chen-Ming Su
Summary: Skeletal muscle atrophy is caused by muscle wasting or reductions in protein associated with aging, injury, and inflammatory processes. The study found an association between HMGB1 and IL-18 signaling in skeletal muscle atrophy, and the HMGB1/IL-18 axis may be a potential target for the treatment of this condition.
Editorial Material
Biochemistry & Molecular Biology
Chih-Hsin Tang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Liang-Wei Lin, Shih-Wei Wang, Wei-Chien Huang, Thanh Kieu Huynh, Chao-Yang Lai, Chih-Yuan Ko, Yi-Chin Fong, Jie-Jen Lee, Shun-Fa Yang, Chih-Hsin Tang
Summary: Neovascular age-related macular degeneration (AMD) is a disease characterized by abnormal blood vessel growth in the retina, leading to severe vision loss. The presence of certain markers in the retinas of AMD patients suggests a contribution of endothelial progenitor cells (EPCs) in this pathogenesis. This study explores the potential of melatonin, a hormone produced in the retina, to inhibit EPC angiogenesis in neovascular AMD. The results demonstrate that melatonin can effectively inhibit the formation of EPC blood vessels and shows promise as a potential treatment for neovascular AMD.
Article
Biochemistry & Molecular Biology
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang
Summary: This study aims to investigate the role of miRNAs in CCL2-mediated MMP expression and cell motility in human osteosarcoma. The results demonstrate a positive correlation between CCL2 or MMP-3 levels and osteosarcoma metastasis, and stimulation of osteosarcoma cells with CCL2 enhances migration and invasion abilities. Additionally, CCL2 enhances MMP-3-dependent cell motility by inhibiting miR-3659 synthesis.
Article
Biochemistry & Molecular Biology
Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong, Chih-Hsin Tang
Summary: Chondrosarcoma, the second most common bone cancer, is difficult to treat surgically when it is high-grade and metastatic. Doxorubicin (Dox) is commonly used in chemotherapy, but drug resistance hampers its effectiveness. This study found that the apelin (APLN) pathway is highly activated in Dox-resistant cells and in high-grade chondrosarcoma tissues. Inhibition of the APLN axis has shown therapeutic benefits in other cancers, and this study suggests that targeting APLN may improve the treatment of chondrosarcoma by overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Chih-Chun Chuang, Kai Wang, Yi-Sun Yang, Edy Kornelius, Chih-Hsin Tang, Chia-Yi Lee, Hsiang-Wen Chien, Shun-Fa Yang
Summary: The study investigates the correlation between single-nucleotide polymorphisms (SNP) of HOX transcript antisense intergenic RNA (HOTAIR) and the clinical characteristics of diabetic retinopathy (DR). The results indicate that HOTAIR SNP rs12427129 and rs1899663 are strongly associated with the presence of DR, especially in female patients with proliferative diabetic retinopathy (PDR).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
