A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

Model-Based Methods in the Biopharmaceutical Process Lifecycle

(2017) Paul Kroll et al.   PHARMACEUTICAL RESEARCH

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data

(2015) Michael Sokolov et al.   BIOTECHNOLOGY PROGRESS

Enabling network inference methods to handle missing data and outliers

(2015) Abel Folch-Fortuny et al.   BMC BIOINFORMATICS

Real time optimization based on a serial hybrid model for gold cyanidation leaching process

(2015) Jun Zhang et al.   MINERALS ENGINEERING

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

(2014) Sarah M. Mercier et al.   TRENDS IN BIOTECHNOLOGY

Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein

(2012) Yolande Rouiller et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A general hybrid semi-parametric process control framework

(2012) Moritz von Stosch et al.   JOURNAL OF PROCESS CONTROL

Hybrid modeling for the prediction of leaching rate in leaching process based on negative correlation learning bagging ensemble algorithm

(2011) Guanghao Hu et al.   COMPUTERS & CHEMICAL ENGINEERING

A novel identification method for hybrid (N)PLS dynamical systems with application to bioprocesses

(2011) M. von Stosch et al.   EXPERT SYSTEMS WITH APPLICATIONS

Identification of semi-parametric hybrid process models

(2010) Aidong Yang et al.   COMPUTERS & CHEMICAL ENGINEERING

Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative

(2009) A.P. Teixeira et al.   BIOTECHNOLOGY ADVANCES

Logistic Equations Effectively Model Mammalian Cell Batch and Fed-Batch Kinetics by Logically Constraining the Fit

(2005) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS

A Hybrid Model Framework for the Optimization of Preparative Chromatographic Processes

(2004) Deepak Nagrath et al.   BIOTECHNOLOGY PROGRESS