In‐silico media optimization for continuous cultures using genome scale metabolic networks: The case of CHO‐K1

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model – Application to amino acid depletion in CHO cell culture

(2017) Erika Hagrot et al.   JOURNAL OF BIOTECHNOLOGY

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

(2017) Jorge Fernandez-de-Cossio-Diaz et al.   PLoS Computational Biology

Limits of aerobic metabolism in cancer cells

(2017) Jorge Fernandez-de-Cossio-Diaz et al.   Scientific Reports

Macromolecular crowding explains overflow metabolism in cells

(2016) Alexei Vazquez et al.   Scientific Reports

The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization

(2016) Elad Noor et al.   PLoS Computational Biology

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism

(2016) Hooman Hefzi et al.   Cell Systems

Macroscopic modeling of mammalian cell growth and metabolism

(2015) Bassem Ben Yahia et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Tailoring recombinant protein quality by rational media design

(2015) David Brühlmann et al.   BIOTECHNOLOGY PROGRESS

White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium

(2015) Konstantin B. Konstantinov et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metabolic responses of CHO cells to limitation of key amino acids

(2014) Tiago M. Duarte et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective

(2014) Alan J Dickson   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

(2013) Nuno Carinhas et al.   BIOTECHNOLOGY AND BIOENGINEERING

Redox balance is key to explaining full vs. partial switching to low-yield metabolism

(2012) Milan JA van Hoek et al.   BMC Systems Biology

‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro

(2011) Alexandros Kiparissides et al.   AUTOMATICA

Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

(2011) Christopher A. Sellick et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

(2011) Paula Meleady et al.   BMC BIOTECHNOLOGY

Growth, productivity and protein glycosylation in a CHO EpoFc producer cell line adapted to glutamine-free growth

(2011) Michael Taschwer et al.   JOURNAL OF BIOTECHNOLOGY

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Molecular Crowding Defines a Common Origin for the Warburg Effect in Proliferating Cells and the Lactate Threshold in Muscle Physiology

(2011) Alexei Vazquez et al.   PLoS One

Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect

(2011) Tomer Shlomi et al.   PLoS Computational Biology

CHO-K1 host cells adapted to growth in glutamine-free medium by FACS-assisted evolution

(2010) Juan A. Hernández Bort et al.   Biotechnology Journal

The biomass objective function

(2010) Adam M Feist et al.   CURRENT OPINION IN MICROBIOLOGY

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING

ATP synthase: From sequence to ring size to the P/O ratio

(2010) S. J. Ferguson   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of transport and phosphorylation of glucose in cancer cells

(2009) Sara Rodríguez-Enríquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Shifts in growth strategies reflect tradeoffs in cellular economics

(2009) Douwe Molenaar et al.   Molecular Systems Biology

Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures

(2008) Olivier Henry et al.   BIOTECHNOLOGY PROGRESS

Mammalian cell culture scale-up and fed-batch control using automated flow cytometry

(2008) G SITTON et al.   JOURNAL OF BIOTECHNOLOGY

Modeling Hybridoma Cell Metabolism Using a Generic Genome-Scale Metabolic Model of Mus musculus

(2005) Kashif Sheikh et al.   BIOTECHNOLOGY PROGRESS