Hybrid modeling — a key enabler towards realizing digital twins in biopharma?

Towards in silico Process Modeling for Vaccines

(2021) Antonio Gaetano Cardillo et al.   TRENDS IN BIOTECHNOLOGY

Hybrid Models for the simulation and prediction of chromatographic processes for protein capture

(2021) Harini Narayanan et al.   JOURNAL OF CHROMATOGRAPHY A

Hybrid‐EKF: Hybrid Model coupled with Extended Kalman Filter for real‐time monitoring and control of mammalian cell culture

(2020) Harini Narayanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Transformed Upstream Bioprocess Data Provides Insights into Biological System Variation

(2020) Anne Richelle et al.   Biotechnology Journal

Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing

(2020) Jens Smiatek et al.   TRENDS IN BIOTECHNOLOGY

Decision Making and Risk Management in Biopharmaceutical Engineering—Opportunities in the Age of Covid-19 and Digitalization

(2020) Michael Sokolov   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable Without a Digital-Twin?

(2019) Steffen Zobel-Roos et al.   Processes

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

(2019) Harini Narayanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Data science tools and applications on the way to Pharma 4.0

(2019) Valentin Steinwandter et al.   DRUG DISCOVERY TODAY

Bioprocessing in the Digital Age: The Role of Process Models

(2019) Harini Narayanan et al.   Biotechnology Journal

110th Anniversary: Commentary: The Smart Human in Smart Manufacturing

(2019) B. Wayne Bequette   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Show Me the Money! Process Modeling in Pharma from the Investor’s Point of View

(2019) Varsakelis et al.   Processes

Engineering challenges in therapeutic protein product and process design

(2019) Maria M. Papathanasiou et al.   Current Opinion in Chemical Engineering

Production of Butyric Anhydride Using Single Reactive Distillation Column with Internal Material Circulation

(2019) Guanghui Chen et al.   Processes

Digital twin driven prognostics and health management for complex equipment

(2018) Fei Tao et al.   CIRP ANNALS-MANUFACTURING TECHNOLOGY

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach

(2016) Songsong Liu et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Linking Models and Experiments

(2016) D. Bonvin et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Taking the Human Out of the Loop: A Review of Bayesian Optimization

(2016) Bobak Shahriari et al.   PROCEEDINGS OF THE IEEE

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

(2014) Sarah M. Mercier et al.   TRENDS IN BIOTECHNOLOGY

Local identification of scalar hybrid models with tree structure

(2008) B. Fiedler et al.   IMA JOURNAL OF APPLIED MATHEMATICS