The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

Caloric restriction in humans reveals immunometabolic regulators of health span

(2022) O. Spadaro et al.   SCIENCE

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

(2020) Joon-Il Jun et al.   Nature Communications

Type I interferon sensing unlocks dormant adipocyte inflammatory potential

(2020) Calvin C. Chan et al.   Nature Communications

TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages

(2020) Petra Mlcochova et al.   Cell Reports

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

(2020) June K Corrigan et al.   eLife

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

(2020) Hui Gao et al.   Cell Metabolism

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

(2019) Adriaan A. van Beek et al.   TRENDS IN IMMUNOLOGY

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

(2019) Bérénice A. Benayoun et al.   GENOME RESEARCH

Structural and functional study of FK domain of Fstl1

(2019) Xinxin Li et al.   PROTEIN SCIENCE

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

(2019) William E Kraus et al.   Lancet Diabetes & Endocrinology

Progress and challenges in analyzing rodent energy expenditure

(2019) Rodrigo Fernández-Verdejo et al.   NATURE METHODS

Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis

(2018) Lindsay T. McDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

(2018) Lucille C. Rankin et al.   CELL

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

The Role of Chemokines in Wound Healing

(2018) Anisyah Ridiandries et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia

(2017) Ashley McDonough et al.   JOURNAL OF NEUROSCIENCE

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

(2017) Christina D. Camell et al.   NATURE

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury

(2016) Ling-juan Zhang et al.   IMMUNITY

IRF3 promotes adipose inflammation and insulin resistance and represses browning

(2016) Manju Kumari et al.   JOURNAL OF CLINICAL INVESTIGATION

PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense

(2016) Hui Jiang et al.   JOURNAL OF IMMUNOLOGY

Novel regulators of cardiac inflammation: Matricellular proteins expand their repertoire

(2016) Marieke Rienks et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Effects of Interferons and Viruses on Metabolism

(2016) Stephanie Deborah Fritsch et al.   Frontiers in Immunology

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

(2015) Hiroe Toba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair

(2015) Lulu Sun et al.   Cell Host & Microbe

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

(2015) Eric Ravussin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing

(2015) Joon-Il Jun et al.   Nature Communications

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages

(2014) Faruk Sheikh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

SPARC is over-expressed in adipose tissues of diet-induced obese rats and causes insulin resistance in 3T3-L1 adipocytes

(2013) Yang Shen et al.   ACTA HISTOCHEMICA

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

The lifespan-reproduction trade-off under dietary restriction is sex-specific and context-dependent

(2013) Margo I. Adler et al.   EXPERIMENTAL GERONTOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Serum SPARC and Matrix Metalloproteinase-2 and Metalloproteinase-9 Concentrations after Bariatric Surgery in Obese Adults

(2013) Yeon Ji Lee et al.   OBESITY SURGERY

Secreted Protein Acidic and Rich in Cysteine (SPARC) Exacerbates Colonic Inflammatory Symptoms in Dextran Sodium Sulphate-Induced Murine Colitis

(2013) Yoke-Leng Ng et al.   PLoS One

Elevated Plasma SPARC Levels Are Associated with Insulin Resistance, Dyslipidemia, and Inflammation in Gestational Diabetes Mellitus

(2013) Lu Xu et al.   PLoS One

Exogenous SPARC Suppresses Proliferation and Migration of Prostate Cancer by Interacting With Integrin β1

(2013) Minkyoung Shin et al.   PROSTATE

Measuring Energy Metabolism in the Mouse – Theoretical, Practical, and Analytical Considerations

(2013) John R. Speakman   Frontiers in Physiology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Homeostasis and function of regulatory T cells in aging

(2012) Jana Raynor et al.   CURRENT OPINION IN IMMUNOLOGY

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

(2012) Wei-Chun Huang et al.   PLoS One

Energy Intake and Response to Infection with Influenza

(2011) Elizabeth M. Gardner et al.   Annual Review of Nutrition

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

(2011) Lee B. Rivera et al.   JOURNAL OF CELL BIOLOGY

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-  Production in a Receptor for Advanced Glycation End Product-Dependent Manner

(2010) B. H. Ruan et al.   JOURNAL OF IMMUNOLOGY

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

(2010) R. Khorooshi et al.   JOURNAL OF IMMUNOLOGY

Adipose tissue macrophages: their role in adipose tissue remodeling

(2010) Takayoshi Suganami et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy

(2010) James Rochon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SPARC: a key player in the pathologies associated with obesity and diabetes

(2010) Katarina Kos et al.   Nature Reviews Endocrinology

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Age-related changes in total and regional fat distribution

(2009) Jennifer L. Kuk et al.   AGEING RESEARCH REVIEWS

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin, and Glucose

(2009) K. Kos et al.   DIABETES

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE