Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors

Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry

(2021) G. Morris et al.   MOLECULAR NEUROBIOLOGY

Nrf2 regulates cell motility through RhoA–ROCK1 signalling in non-small-cell lung cancer cells

(2021) Eunsun Ko et al.   Scientific Reports

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

(2021) Wei Yao et al.   Translational Psychiatry

Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications

(2021) Ahmed Alengebawy et al.   Toxics

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

(2021) Zhewei Zhao et al.   Aging-US

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects

(2021) Katie Frenis et al.   BASIC RESEARCH IN CARDIOLOGY

Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway

(2021) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transportation noise pollution and cardiovascular disease

(2021) Thomas Münzel et al.   Nature Reviews Cardiology

Work Shift, Lifestyle Factors, and Subclinical Atherosclerosis in Spanish Male Workers: A Mediation Analysis

(2021) José L. Peñalvo et al.   Nutrients

The Role of Nrf2 in Hearing Loss

(2021) Dafei Li et al.   Frontiers in Pharmacology

Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis

(2021) Maria Teresa Bayo Jimenez et al.   Antioxidants

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Getting Sympathetic About Air Pollution Exposure

(2021) Robert D. Brook et al.   Journal of the American Heart Association

Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen

(2021) Guifang Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

SH-29 and SK-119 Attenuates Air-Pollution Induced Damage by Activating Nrf2 in HaCaT Cells

(2021) Shirin Kahremany et al.   International Journal of Environmental Research and Public Health

Adverse Cardiovascular Effects of Traffic Noise with a Focus on Nighttime Noise and the New WHO Noise Guidelines

(2020) Thomas Münzel et al.   Annual Review of Public Health

Noise annoyance predicts symptoms of depression, anxiety and sleep disturbance 5 years later. Findings from the Gutenberg Health Study

(2020) Manfred E Beutel et al.   EUROPEAN JOURNAL OF PUBLIC HEALTH

Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

(2020) Andreas Daiber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2

(2020) Wenjun Wang et al.   Aging-US

Environmental Factors Such as Noise and Air Pollution and Vascular Disease

(2020) Thomas Münzel et al.   ANTIOXIDANTS & REDOX SIGNALING

Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of Metals and Polycyclic Aromatic Hydrocarbons

(2020) Michal Pardo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid, in rats

(2020) C. Batandier et al.   NUTRITION RESEARCH

Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases

(2020) Andreas Daiber et al.   Redox Biology

Redox toxicology of environmental chemicals causing oxidative stress

(2020) Fuli Zheng et al.   Redox Biology

Corilagin ameliorates sleep deprivation-induced memory impairments by inhibiting NOX2 and activating Nrf2

(2020) Wenjun Wang et al.   BRAIN RESEARCH BULLETIN

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes

(2020) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

(2020) Samanta C. Funes et al.   Frontiers in Immunology

Sulforaphane Reverses the Amyloid-β Oligomers Induced Depressive-Like Behavior

(2020) Wei Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

(2020) Luoyao Yang et al.   Redox Biology

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

(2020) Diana Maria Chitimus et al.   Biomolecules

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

(2020) Marisol Fernández-Ortiz et al.   Antioxidants

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis

(2019) Nooshin Javaheipour et al.   SLEEP MEDICINE REVIEWS

Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions

(2019) Jos Lelieveld et al.   EUROPEAN HEART JOURNAL

Genetic sleep deprivation: using sleep mutants to study sleep functions

(2019) Henrik Bringmann   EMBO REPORTS

Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood–brain barrier impairment

(2019) Farzane Sivandzade et al.   BMC NEUROSCIENCE

Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage

(2019) Shirin Kahremany et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

(2019) Errol M. Thomson   JOURNAL OF ALZHEIMERS DISEASE

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex

(2019) Xiaofeng Guo et al.   AGING CELL

Effects of Molecular-Level Compositional Variability in Organic Aerosol on Phase State and Thermodynamic Mixing Behavior

(2019) Jenna C. Ditto et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ

(2019) Bobo Yang et al.   TOXICOLOGY

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

(2019) Johannes Herzog et al.   BASIC RESEARCH IN CARDIOLOGY

Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice

(2019) Samanta C. Funes et al.   IMMUNOLOGY

Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice

(2019) Li-Heng Tuan et al.   NEUROBIOLOGY OF DISEASE

The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress

(2019) Ayat Al-Ghafari et al.   PLoS One

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection

(2019) Huige Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization

(2019) Patrycja Michalska et al.   PHARMACOLOGICAL RESEARCH

Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway

(2019) Chang Liu et al.   International Journal of Environmental Research and Public Health

Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective

(2018) Pietro Ghezzi et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Diesel Exhaust on Cardiovascular Function and Oxidative Stress

(2018) Simon J. Wilson et al.   ANTIOXIDANTS & REDOX SIGNALING

The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk

(2018) Thomas Münzel et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation

(2018) Rou-Ling Cho et al.   BIOCHEMICAL PHARMACOLOGY

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Data integration for the assessment of population exposure to ambient air pollution for global burden of disease assessment.

(2018) Gavin Shaddick et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

(2018) Swenja Kröller-Schön et al.   EUROPEAN HEART JOURNAL

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Protective effects of dietary luteolin against mercuric chloride-induced lung injury in mice: Involvement of AKT/Nrf2 and NF-κB pathways

(2018) Biying Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Environmental Noise and the Cardiovascular System

(2018) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Lancet Commission on pollution and health

(2018) Philip J Landrigan et al.   LANCET

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation

(2018) Hironobu Ikehata   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Volatile chemical products emerging as largest petrochemical source of urban organic emissions

(2018) Brian C. McDonald et al.   SCIENCE

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

(2018) Shirin Kahremany et al.   ChemPlusChem

WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Cardiovascular and Metabolic Effects: A Summary

(2018) Elise van Kempen et al.   International Journal of Environmental Research and Public Health

Effects of gaseous and solid constituents of air pollution on endothelial function

(2018) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Walnut (Juglans regia) Peptides Reverse Sleep Deprivation-Induced Memory Impairment in Rat via Alleviating Oxidative Stress

(2018) Shuguang Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter

(2018) Richard Burnett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 deficiency exacerbates PM2.5-induced olfactory bulb injury

(2018) Xiaoyu Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Air Pollution and Cardiovascular Disease

(2018) Sanjay Rajagopalan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome

(2018) Wenqi Gao et al.   METABOLIC BRAIN DISEASE

Molecular characterization of ABHD5 gene promoter in intramuscular preadipocytes of Qinchuan cattle: Roles of Evi1 and C/EBPα

(2018) Xiaoyu Wang et al.   GENE

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway

(2018) Junmin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

(2017) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland

(2017) Harris Héritier et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

(2017) Saowanee Jeayeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Roles of Oxidative Stress in Metal Carcinogenesis

(2017) Jie Xu et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Arbutus andrachne L. Reverses Sleep Deprivation-Induced Memory Impairments in Rats

(2017) Karem H. Alzoubi et al.   MOLECULAR NEUROBIOLOGY

A review of sleep disorders and melatonin

(2017) Zizhen Xie et al.   NEUROLOGICAL RESEARCH

Cadmium exposure and endometrial cancer risk: A large midwestern U.S. population-based case-control study

(2017) Jane A. McElroy et al.   PLoS One

Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells by luteolin through Nrf2 signaling

(2017) Young-Ok Son et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impact of Oxidant Gases on the Relationship between Outdoor Fine Particulate Air Pollution and Nonaccidental, Cardiovascular, and Respiratory Mortality

(2017) Scott Weichenthal et al.   Scientific Reports

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

(2017) Mohammad A. Kaisar et al.   Redox Biology

Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice

(2016) Shuhui Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Targeting vascular (endothelial) dysfunction

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

Superoxide Ion: Generation and Chemical Implications

(2016) Maan Hayyan et al.   CHEMICAL REVIEWS

Residential exposure to traffic noise and risk of incident atrial fibrillation: A cohort study

(2016) Maria Monrad et al.   ENVIRONMENT INTERNATIONAL

Dermal Uptake from Airborne Organics as an Important Route of Human Exposure to E-Waste Combustion Fumes

(2016) Chen-Chou Wu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways

(2016) Shu-Hua Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

Plasma heme oxygenase-1 is decreased in peripheral artery disease patients

(2016) Salvatore Santo Signorelli et al.   Molecular Medicine Reports

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

(2016) E Bouvier et al.   MOLECULAR PSYCHIATRY

Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage

(2016) Huaping Li et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Sleep and mental disorders: A meta-analysis of polysomnographic research.

(2016) Chiara Baglioni et al.   PSYCHOLOGICAL BULLETIN

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice

(2016) Wei Yao et al.   Scientific Reports

Exposure to Agrochemicals and Cardiovascular Disease: A Review

(2016) Matome Sekhotha et al.   International Journal of Environmental Research and Public Health

Noise Annoyance Is Associated with Depression and Anxiety in the General Population- The Contribution of Aircraft Noise

(2016) Manfred E. Beutel et al.   PLoS One

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea

(2016) Yohei Honkura et al.   Scientific Reports

Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis

(2015) Joanne Booth et al.   BMC Neurology

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a ‘drug-prodrug’ mechanism of action

(2015) Javier Egea et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

(2015) E. V. Knatko et al.   Cancer Prevention Research

Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway

(2015) Nazimabashir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A review on the human health impact of airborne particulate matter

(2015) Ki-Hyun Kim et al.   ENVIRONMENT INTERNATIONAL

Arsenic and Environmental Health: State of the Science and Future Research Opportunities

(2015) Danielle J. Carlin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans

(2015) Philip Wenzel et al.   EUROPEAN HEART JOURNAL

Road traffic noise is associated with increased cardiovascular morbidity and mortality and all-cause mortality in London

(2015) Jaana I. Halonen et al.   EUROPEAN HEART JOURNAL

Nrf2 deficiency causes lipid oxidation, inflammation, and matrix-protease expression in DHA-supplemented and UVA-irradiated skin fibroblasts

(2015) Florian Gruber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

(2015) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Environmental factors in cardiovascular disease

(2015) Kristen E. Cosselman et al.   Nature Reviews Cardiology

Job Strain and the Risk of Stroke

(2015) Eleonor I. Fransson et al.   STROKE

Mortality in Mental Disorders and Global Disease Burden Implications

(2015) Elizabeth Reisinger Walker et al.   JAMA Psychiatry

An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia

(2015) Akihiro Shiina et al.   Clinical Psychopharmacology and Neuroscience

Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions

(2015) Sebastian Oeder et al.   PLoS One

Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood

(2015) Yumi Shirai et al.   PLoS One

Selective turnover of p62/A170/SQSTM1 by autophagy

(2014) Yoshinobu Ichimura et al.   Autophagy

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

(2014) Mary C Sheehan et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Job Strain as a Risk Factor for Type 2 Diabetes: A Pooled Analysis of 124,808 Men and Women

(2014) Solja T. Nyberg et al.   DIABETES CARE

Long-Term Aircraft Noise Exposure and Body Mass Index, Waist Circumference, and Type 2 Diabetes: A Prospective Study

(2014) Charlotta Eriksson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cardiovascular effects of environmental noise exposure

(2014) T. Munzel et al.   EUROPEAN HEART JOURNAL

Expert position paper on air pollution and cardiovascular disease

(2014) David E. Newby et al.   EUROPEAN HEART JOURNAL

Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   Journal of Neuroinflammation

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Agmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line

(2014) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

(2014) Alexandra Amaro-Ortiz et al.   MOLECULES

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Association among depressive disorder, adjustment disorder, sleep disturbance, and suicidal ideation in Taiwanese adolescent

(2013) Ming-Shun Chung et al.   Asia-Pacific Psychiatry

Long-Term Exposure to Concentrated Ambient PM 2.5 Increases Mouse Blood Pressure through Abnormal Activation of the Sympathetic Nervous System: A Role for Hypothalamic Inflammation

(2013) Zhekang Ying et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nighttime aircraft noise exposure: flying towards arterial disease

(2013) M. Charakida et al.   EUROPEAN HEART JOURNAL

Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study

(2013) H. Kalsch et al.   EUROPEAN HEART JOURNAL

Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults

(2013) F. P. Schmidt et al.   EUROPEAN HEART JOURNAL

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

(2013) Esther Parada et al.   JOURNAL OF PINEAL RESEARCH

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane: translational research from laboratory bench to clinic

(2013) Christine A Houghton et al.   NUTRITION REVIEWS

Is hypertension associated with job strain? A meta-analysis of observational studies

(2013) Giridhara R Babu et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice

(2013) Mark R Miller et al.   Particle and Fibre Toxicology

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

(2013) María Dolores Martín-de-Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles

(2013) David Heber et al.   Food & Function

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

(2013) Shasha Tao et al.   Redox Biology

Ameliorative effects of curcumin against acute cadmium toxicity on male reproductive system in rats

(2012) H. Oguzturk et al.   ANDROLOGIA

Severe Life Stress and Oxidative Stress in the Brain: From Animal Models to Human Pathology

(2012) Stefania Schiavone et al.   ANTIOXIDANTS & REDOX SIGNALING

T Lymphocytes and Vascular Inflammation Contribute to Stress-Dependent Hypertension

(2012) Paul J. Marvar et al.   BIOLOGICAL PSYCHIATRY

Global Air Quality and Health Co-benefits of Mitigating Near-Term Climate Change through Methane and Black Carbon Emission Controls

(2012) Susan C. Anenberg et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

SVOC exposure indoors: fresh look at dermal pathways

(2012) C. J. Weschler et al.   INDOOR AIR

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation

(2012) Wenpeng Cui et al.   Oxidative Medicine and Cellular Longevity

Nrf2 activation prevents cadmium-induced acute liver injury

(2012) Kai C. Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glucosinolates and isothiocyanates in health and disease

(2012) Albena T. Dinkova-Kostova et al.   TRENDS IN MOLECULAR MEDICINE

Effects of the Antioxidant Sulforaphane on Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Phencyclidine Administration

(2012) Yumi Shirai et al.   Clinical Psychopharmacology and Neuroscience

Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury

(2011) Takashi Toyama et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Road traffic noise and stroke: a prospective cohort study

(2011) M. Sorensen et al.   EUROPEAN HEART JOURNAL

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases

(2011) Yuji Naito et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

(2011) Han-Cheon Um et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Arsenic Exposure and Toxicology: A Historical Perspective

(2011) Michael F. Hughes et al.   TOXICOLOGICAL SCIENCES

Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes

(2011) Cevat Aktas et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Double antioxidant activities of rosiglitazone against high glucose-induced oxidative stress in hepatocyte

(2011) Xin Wang et al.   TOXICOLOGY IN VITRO

Cardiovascular effects of noise

(2011) Wolfgang Babisch   Noise & Health

Particulate Matter Air Pollution and Cardiovascular Disease

(2010) Robert D. Brook et al.   CIRCULATION

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Greater Cardiovascular Responses to Laboratory Mental Stress Are Associated With Poor Subsequent Cardiovascular Risk Status

(2010) Yoichi Chida et al.   HYPERTENSION

Inflammation, Immunity, and Hypertension

(2010) David G. Harrison et al.   HYPERTENSION

Review: Ultraviolet radiation and skin cancer

(2010) Deevya L. Narayanan et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin

(2010) Thomas Jansen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane

(2010) Constance L. Saw et al.   MOLECULAR CARCINOGENESIS

The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells

(2010) Georg Wondrak et al.   MOLECULES

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

(2010) Mingwei Ni et al.   TOXICOLOGICAL SCIENCES

Bronchodilatory Effect of the PPAR-γ Agonist Rosiglitazone in Smokers With Asthma

(2009) M Spears et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of atmospheric pollutants on the Nrf2 survival pathway

(2009) Valentina Rubio et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells

(2009) Florian Gruber et al.   FASEB JOURNAL

Biological Responses to Arsenic Compounds

(2009) Leonidas C. Platanias   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of Developmental Heart Defects by Dioxins, PCBs, and Pesticides

(2009) PHILLIP G. KOPF et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Nrf2 protects against As(III)-induced damage in mouse liver and bladder

(2009) Tao Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cysteine-based regulation of the CUL3 adaptor protein Keap1

(2009) Konjeti R. Sekhar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities

(2008) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[ a ]pyrene-treated mice: mechanism of its anti-initiating action

(2008) Rachana Garg et al.   CARCINOGENESIS

Prospective Type 1 and Type 2 Disulfides of Keap1 Protein

(2008) Ryan Holland et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response

(2008) Yu Du et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Direct Impairment of Vascular Function by Diesel Exhaust Particulate through Reduced Bioavailability of Endothelium-Derived Nitric Oxide Induced by Superoxide Free Radicals

(2008) Mark R. Miller et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Characterisation of urban inhalation exposures to benzene, formaldehyde and acetaldehyde in the European Union

(2008) Yuri Bruinen de Bruin et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

(2008) Georg T. Wondrak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The joint association of air pollution and noise from road traffic with cardiovascular mortality in a cohort study

(2008) R Beelen et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Persistent, bioaccumulative and toxic substances in fish: Human health considerations

(2008) José G. Dórea   SCIENCE OF THE TOTAL ENVIRONMENT

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes

(2008) Ling Wang et al.   TOXICOLOGICAL SCIENCES

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction

(2008) Xiao-Jun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH