Article
Nutrition & Dietetics
Joseph Yusin, Vivian Wang, Susanne M. Henning, Jieping Yang, Chi-Hong Tseng, Gail Thames, Irina Arnold, David Heber, Ru-Po Lee, Laura Sanavio, Yajing Pan, Tianyu Qin, Zhaoping Li
Summary: Combining nasal corticosteroid with broccoli sprout extract led to the most significant improvement in peak nasal inspiratory flow and total nasal symptoms scores in patients diagnosed with grass-induced allergic rhinitis.
Article
Oncology
Julie E. Bauman, Chiu-Hsieh Hsu, Sara Centuori, Jose Guillen-Rodriguez, Linda L. Garland, Emily Ho, Megha Padi, Vignesh Bageerathan, Lisa Bengtson, Malgorzata Wojtowicz, Eva Szabo, H. -H. Sherry Chow
Summary: Consumption of cruciferous vegetables is associated with reduced risk of tobacco-related cancers. This study evaluated the detoxification of tobacco carcinogens by broccoli seed and sprout extract (BSSE) in tobacco smokers. The higher dose of BSSE significantly increased the detoxification of benzene, acrolein, and crotonaldehyde in smokers.
Article
Biochemistry & Molecular Biology
Tao Zhang, Johanna Holman, Delaney McKinstry, Bruno C. Trindade, Kathryn A. Eaton, Jonny Mendoza-Castrejon, Sharon Ho, Emily Wells, Hebao Yuan, Bo Wen, Duxin Sun, Grace Y. Chen, Yanyan Li
Summary: In this study, the researchers investigated the therapeutic effects of steamed broccoli sprouts on colitis using a mouse model of inflammatory bowel disease. Despite the inactivation of the enzyme responsible for producing sulforaphane, measurable levels of sulforaphane were still detected in the colon tissue and feces of mice after consuming steamed broccoli sprouts. Furthermore, steamed broccoli sprouts were found to reduce chemically-induced colitis, and this protective effect was dependent on the presence of a healthy gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Zinian Wang, Chengjian Tu, Rachel Pratt, Thaer Khoury, Jun Qu, Jed W. Fahey, Susan E. McCann, Yuesheng Zhang, Yue Wu, Alan D. Hutson, Christine B. Ambrosone, Stephen B. Edge, Helen H. Cappuccino, Kazuaki Takabe, Jessica S. Young, Li Tang
Summary: This study confirms the anti-cancer activities of dietary isothiocyanates (ITCs) from cruciferous vegetables in breast cancer patients. The results show that these substances can alter the expression of tumor biomarkers, supporting their potential beneficial roles in breast cancer prognosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Plant Sciences
Xiao Men, Xionggao Han, Se-Jeong Lee, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee
Summary: In this study, HPLC analytical methods were developed to determine glucoraphanin (GRA) and sulforaphane (SFN) in mustard seed powder (MSP), broccoli sprout powder (BSP), and the MSP-BSP mixture powder (MBP). The anti-adipogenic effects of BSP and MBP were evaluated in 3T3-L1 adipocytes. The results showed that both BSP and MBP effectively decreased lipid accumulation content without cytotoxicity. They also inhibited the expression of adipogenic proteins and increased the expression of lipolysis-related proteins. MBP exerted a greater anti-adipogenic effect than BSP in 3T3-L1 preadipocytes.
Article
Biochemistry & Molecular Biology
Sajad Shokri, Hema Jegasothy, Mary Ann Augustin, Netsanet Shiferaw Terefe
Summary: The study showed that thermosonication can enhance the yield of sulforaphane in broccoli, despite a decrease in myrosinase activity. The highest yield was achieved under the treatment of thermosonication at 60 degrees Celsius for 7 minutes, which also increased the residual level of sulforaphane, indicating the potential for converting broccoli biomass into high sulforaphane ingredients.
Article
Biochemistry & Molecular Biology
Francis Gonzalez, Julian Quintero, Rodrigo Del Rio, Andrea Mahn
Summary: An eco-friendly extraction process was studied to obtain an SFN-rich extract from broccoli. The effects of broccoli mass/solvent ratio, ethanol concentration, and extraction time on the recovery of SFN, GFN, phenolic compounds, and antioxidant activity were investigated. Experimental factors showed different impacts on the recovery of bioactive compounds and antioxidant activity in the extracts.
Article
Nutrition & Dietetics
Neville J. Fields, Kirsten R. Palmer, Daniel L. Rolnik, Jennifer Yo, Marcel F. Nold, Michelle L. Giles, Sushena Krishnaswamy, Ary Serpa Neto, Ryan J. Hodges, Sarah A. Marshall, Bruce W. Hollis
Summary: This study aims to evaluate the effects of using a broccoli sprout supplement on the duration of symptoms, maternal and neonatal outcomes, and biomarkers in pregnant women with COVID-19 infection. By conducting a pilot, double-blinded, placebo-controlled randomized trial, researchers plan to enroll 60 pregnant women with COVID-19 and treat them for 14 days, assessing the feasibility and safety of the broccoli sprout supplement.
Article
Food Science & Technology
Masahiro Kikuchi, Yudai Aoki, Noriaki Kishimoto, Yumi Masuda, Nana Suzuki, Shinji Takashimizu, Kazutaka Yoshida, Koichi Aizawa, Hiroyuki Suganuma, Yasuhiro Nishizaki
Summary: Sulforaphane may improve sleep quality by increasing melatonin and anti-inflammatory activity, showing a significant positive effect on sleep quality.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Xiao Men, Xionggao Han, Se-Jeong Lee, Geon Oh, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee
Summary: It was found that broccoli sprout powder, mustard seed powder, and sulforaphane-rich mixture powder have anti-obesogenic effects by inhibiting adipocyte differentiation and adipogenesis, and by increasing the expression of proteins related to lipid metabolism and lipolysis.
Article
Chemistry, Multidisciplinary
Yao Zhang, Chunmin Jiang, Sisi Huang, Juan Sun, Xinjie Song, Sabir Z. Nishanbaev, Maria Jose Benito, Yuanfeng Wu
Summary: Broccoli extract containing polyphenols and glucosinolates exhibits various functions including anticancer, anti-inflammatory, antimicrobial, and atherosclerosis-reducing activities. In this in vitro study, it was found that broccoli extract increased probiotics and inhibited harmful bacteria, improving the richness and structure of gut microorganisms. The hydrolysis of glucosinolates was significantly correlated with specific bacterial taxa.
Article
Biochemistry & Molecular Biology
Sachithra S. Ranaweera, Premkumar Natraj, Priyanka Rajan, Laksi A. Dayarathne, Suyama P. Mihindukulasooriya, Duong Thi Thuy Dinh, Youngheun Jee, Chang-Hoon Han
Summary: The study evaluated the anti-obesity effect of sulforaphane (SFN) and glucoraphanin (GRN) in broccoli leaf extract (BLE) on 3T3-L1 adipocytes and ob/ob mice. SFN and BLE reduced lipid accumulation and TG content, increased glucose uptake, and normalized gene expression related to lipid metabolism in ob/ob mice, suggesting a potential anti-obesity mechanism of SFN in BLE.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Zahra Azarashkan, Ali Motamedzadegan, Azadeh Ghorbani-HasanSaraei, Somayeh Rahaiee, Pourya Biparva
Summary: This study successfully prepared nanocapsules by co-encapsulating broccoli sprout extract nanoliposomes with basil seed gum, and evaluated their physicochemical properties and release of SF. The optimized nanocapsules showed good stability, proper particle size distribution, and slower SF release, making them a promising SF delivery system.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Food Science & Technology
Bingyong Mao, Baojing Ren, Jiaying Wu, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Le Zhang, Wei Chen, Shumao Cui
Summary: Broccoli seed extract (BSE) can be transformed into sulforaphane by intestinal microbes, which has strong anti-inflammatory and antioxidant activities and can effectively alleviate liver injury. BSE can also regulate the levels of inflammatory and anti-inflammatory factors in the liver, as well as improve the diversity of gut microbiota. These results suggest the potential application of BSE in functional foods.
Article
Allergy
Nahyun Kim, Dohyun Han, Injae Joseph Wang, Doo Hee Han, Myung-Whan Suh, Jun Ho Lee, Seung-Ha Oh, Moo Kyun Park
Summary: The study found that the action of diesel exhaust particles (DEP) combined with lipopolysaccharide can significantly affect the secretome of human nasal epithelium, and is associated with biomarkers related to upper airway inflammatory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.