Noise-Induced Vascular Dysfunction, Oxidative Stress, and Inflammation Are Improved by Pharmacological Modulation of the NRF2/HO-1 Axis

Transportation noise pollution and cardiovascular disease

(2021) Thomas Münzel et al.   Nature Reviews Cardiology

Adverse Cardiovascular Effects of Traffic Noise with a Focus on Nighttime Noise and the New WHO Noise Guidelines

(2020) Thomas Münzel et al.   Annual Review of Public Health

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

(2020) Mariapaola Nitti et al.   Frontiers in Physiology

Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension

(2020) Sebastian Steven et al.   Redox Biology

The impact of aircraft noise on vascular and cardiac function in relation to noise event number – a randomized trial

(2020) Frank P Schmidt et al.   CARDIOVASCULAR RESEARCH

Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases

(2020) Sarah A. Scuderi et al.   Antioxidants

Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction—Signatures of the internal exposome

(2019) Andreas Daiber et al.   BIOFACTORS

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

(2019) Johannes Herzog et al.   BASIC RESEARCH IN CARDIOLOGY

The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes

(2019) Alina Hanf et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

(2018) Swenja Kröller-Schön et al.   EUROPEAN HEART JOURNAL

Environmental Noise and the Cardiovascular System

(2018) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Cardiovascular and Metabolic Effects: A Summary

(2018) Elise van Kempen et al.   International Journal of Environmental Research and Public Health

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

(2017) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing-remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies

(2017) E. Havrdova et al.   EUROPEAN JOURNAL OF NEUROLOGY

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury

(2017) Maxime Rossi et al.   Scientific Reports

Heme Oxygenase 1 Up-Regulates Glomerular Decay Accelerating Factor Expression and Minimizes Complement Deposition and Injury

(2016) Maria G. Detsika et al.   AMERICAN JOURNAL OF PATHOLOGY

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting vascular (endothelial) dysfunction

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Road Traffic and Railway Noise Exposures and Adiposity in Adults: A Cross-Sectional Analysis of the Danish Diet, Cancer, and Health Cohort

(2015) Jeppe Schultz Christensen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans

(2015) Philip Wenzel et al.   EUROPEAN HEART JOURNAL

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish ( Danio rerio )

(2015) Mark E. Hahn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Nighttime aircraft noise impairs endothelial function and increases blood pressure in patients with or at high risk for coronary artery disease

(2014) Frank Schmidt et al.   Clinical Research in Cardiology

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

(2014) S. M. Tan et al.   DIABETES

Redox Control of Inflammation in Macrophages

(2013) Bernhard Brüne et al.   ANTIOXIDANTS & REDOX SIGNALING

Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study

(2013) H. Kalsch et al.   EUROPEAN HEART JOURNAL

Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults

(2013) F. P. Schmidt et al.   EUROPEAN HEART JOURNAL

Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging

(2013) Matthias Oelze et al.   HYPERTENSION

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   Redox Biology

Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression

(2012) Matthias Oelze et al.   EUROPEAN HEART JOURNAL

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

(2012) E. Choy   RHEUMATOLOGY

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Suppression of VEGFR2 Expression in Human Endothelial Cells by Dimethylfumarate Treatment: Evidence for Anti-Angiogenic Action

(2011) Markus Meissner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Pentaerythritol Tetranitrate Improves Angiotensin II–Induced Vascular Dysfunction via Induction of Heme Oxygenase-1

(2010) Swenja Schuhmacher et al.   HYPERTENSION

IL-17 in Systemic Lupus Erythematosus

(2010) José C. Crispín et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin

(2010) Thomas Jansen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting the Nrf2 pathway against cardiovascular disease

(2009) Jinqing Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

(2008) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS

Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-κB–PTEN-dependent human cardiac endothelial cell death

(2007) Miguel Zabalgoitia et al.   FREE RADICAL BIOLOGY AND MEDICINE