Protein corona: challenges and opportunities for targeted delivery of nanomedicines

The need for improved methodology in protein corona analysis

(2022) Morteza Mahmoudi   Nature Communications

cRGD enables rapid phagocytosis of liposomal vancomycin for intracellular bacterial clearance

(2022) Guanghui Li et al.   JOURNAL OF CONTROLLED RELEASE

Concepts on Smart Nano-Based Drug Delivery System

(2021) Shweta Rai et al.   Recent Patents on Nanotechnology

Deciphering Protein Corona by scFv-Based Affinity Chromatography

(2021) Yuxiu Chu et al.   NANO LETTERS

Role of vitronectin-rich protein corona on tumor-specific siRNA delivery and transfection with lipid nanoparticles

(2021) Dongyu Chen et al.   Nanomedicine

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

(2021) Fatemeh Oroojalian et al.   Small

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

(2021) Wei Xiao et al.   BIOMATERIALS

Self-Adjuvant Effect by Manipulating the Bionano Interface of Liposome-Based Nanovaccines

(2021) Zhuxuan Jiang et al.   NANO LETTERS

Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance

(2021) Rafaela García-Álvarez et al.   Nanomaterials

The protein corona and its effects on nanoparticle-based drug delivery systems

(2021) Hanmei Li et al.   Acta Biomaterialia

Isolation methods commonly used to study the liposomal protein corona suffer from contamination issues

(2021) Kasper Kristensen et al.   Acta Biomaterialia

Regulation of in vivo delivery of nanomedicines by herbal medicines

(2021) Juan Guan et al.   ADVANCED DRUG DELIVERY REVIEWS

Research progress and application opportunities of nanoparticle–protein corona complexes

(2021) Wei Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Interrogating preclinical study of liposomes: The effect of mouse strain reexamined

(2021) Juan Guan et al.   JOURNAL OF CONTROLLED RELEASE

Cell membrane–camouflaged liposomes for tumor cell–selective glycans engineering and imaging in vivo

(2021) Zhengwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Analysis of Protein Corona on Precoated Protein Nanoparticles and Determined Nanoparticles with Ultralow Protein Corona and Efficient Targeting in Vivo

(2021) Zicheng Zhong et al.   ACS Applied Materials & Interfaces

Unraveling the Effect of Breast Cancer Patients’ Plasma on the Targeting Ability of Folic Acid-Modified Chitosan Nanoparticles

(2021) Mahdieh Nemati et al.   MOLECULAR PHARMACEUTICS

Facile Separation of PEGylated Liposomes Enabled by Anti-PEG scFv

(2021) Wenjing Tang et al.   NANO LETTERS

The influence of surface charge on the tumor-targeting behavior of Fe3O4 nanoparticles for MRI

(2021) Saisai Yue et al.   Journal of Materials Chemistry B

Natural IgM dominates in vivo performance of liposomes

(2020) Tianhao Ding et al.   JOURNAL OF CONTROLLED RELEASE

Hierarchically targetable fiber rods decorated with dual targeting ligands and detachable zwitterionic coronas

(2020) Yuan Liu et al.   Acta Biomaterialia

The Protein Corona Does Not Influence Receptor-Mediated Targeting of Virus-like Particles

(2020) Jirina Zackova Suchanova et al.   BIOCONJUGATE CHEMISTRY

Interactions between biomolecules and zwitterionic moieties: a review

(2020) Amir Erfani et al.   BIOMACROMOLECULES

Functionalized nano-targeted moieties in management of prostate cancer

(2020) Taher A Salaheldin et al.   Future Oncology

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

(2020) Riccardo Rampado et al.   Frontiers in Bioengineering and Biotechnology

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Labeled-protein corona-coated Bi2S3 nanorods targeted to lysosomes for bioimaging and efficient photothermal cancer therapy

(2020) Shouning Yang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Hyaluronic Acid and Controlled Release: A Review

(2020) Ilker S. Bayer   MOLECULES

Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined

(2020) Huan Wang et al.   ACS Nano

Structure of soft and hard protein corona around polystyrene nanoplastics—Particle size and protein types

(2020) Shinji Kihara et al.   Biointerphases

ImmunoPET Imaging of Pancreatic Tumors with 89Zr-Labeled Gold Nanoparticle–Antibody Conjugates

(2020) Nicholas B. Sobol et al.   MOLECULAR IMAGING AND BIOLOGY

Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?

(2020) Ting Zhang et al.   Acta Pharmaceutica Sinica B

Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model

(2020) Mengmeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles

(2020) Tianxu Zhang et al.   MEDICINAL RESEARCH REVIEWS

Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines

(2020) Zui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility

(2019) Juan Guan et al.   MOLECULAR PHARMACEUTICS

Composition design and medical application of liposomes

(2019) Mingyuan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Digestive Enzyme Corona Formed in the Gastrointestinal Tract and Its Impact on Epithelial Cell Uptake of Nanoparticles

(2019) Qiang Peng et al.   BIOMACROMOLECULES

Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

(2019) Zhilan Chai et al.   ACS Nano

Possibilities and Limitations of Different Separation Techniques for the Analysis of the Protein Corona

(2019) Claudia Weber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Red Blood Cells-Derived Vesicles for Delivery of Lipophilic Drug Camptothecin

(2019) Sahil Malhotra et al.   ACS Applied Materials & Interfaces

Active Nano-targeting of Macrophages

(2019) Natasa Gaspar et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

The hard protein corona of stealth liposomes is sparse

(2019) Kasper Kristensen et al.   JOURNAL OF CONTROLLED RELEASE

Task-Specific Design of Immune-Augmented Nanoplatform to Enable High-Efficiency Tumor Immunotherapy

(2019) Jing Zhang et al.   ACS Applied Materials & Interfaces

Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles

(2019) Lívia M.D. Loiola et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Brain-targeted drug delivery by manipulating protein corona functions

(2019) Zui Zhang et al.   Nature Communications

Folate-conjugated nanovehicles: Strategies for cancer therapy

(2019) Batoul Farran et al.   Materials Science & Engineering C-Materials for Biological Applications

Ligand Size and Conformation Affect the Behavior of Nanoparticles Coated with in Vitro and in Vivo Protein Corona

(2018) Huajin Zhang et al.   ACS Applied Materials & Interfaces

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

Red Blood Cells as Smart Delivery Systems

(2018) Xiao Han et al.   BIOCONJUGATE CHEMISTRY

Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

(2018) Limei Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunoliposomes in clinical oncology: State of the art and future perspectives

(2018) María Merino et al.   JOURNAL OF CONTROLLED RELEASE

Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

(2018) Gangliang Huang et al.   JOURNAL OF CONTROLLED RELEASE

RGD peptide-based non-viral gene delivery vectors targeting integrin αvβ3 for cancer therapy

(2018) Shuang Fu et al.   JOURNAL OF DRUG TARGETING

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

(2018) Hira Choudhury et al.   Drug Delivery and Translational Research

Effects of Protein Corona on Active and Passive Targeting of Cyclic RGD Peptides Functionalized PEGylation Nanoparticles

(2018) Gaoxing Su et al.   MOLECULAR PHARMACEUTICS

The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles

(2018) Ding Ding et al.   Nano Research

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

(2018) Juan Guan et al.   Nature Communications

Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles

(2018) Jessica Fernanda Affonso de Oliveira et al.   ACS Applied Materials & Interfaces

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the nanoparticle protein corona

(2017) Valérie Forest et al.   Materials Science & Engineering C-Materials for Biological Applications

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Hyaluronic Acid Coated Chitosan Nanoparticles Reduced the Immunogenicity of the Formed Protein Corona

(2017) Abdulaziz Almalik et al.   Scientific Reports

Improving Targeting of Metal–Phenolic Capsules by the Presence of Protein Coronas

(2016) Yi Ju et al.   ACS Applied Materials & Interfaces

Bypassing Protein Corona Issue on Active Targeting: Zwitterionic Coatings Dictate Specific Interactions of Targeting Moieties and Cell Receptors

(2016) Reihaneh Safavi-Sohi et al.   ACS Applied Materials & Interfaces

Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation

(2016) Fangda Xu et al.   ACS Nano

Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties

(2016) Arafeh Bigdeli et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Folate-Binding Protein Self-Aggregation Drives Agglomeration of Folic Acid Targeted Iron Oxide Nanoparticles

(2016) Junjie Chen et al.   BIOCONJUGATE CHEMISTRY

Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization

(2016) Melissa Santi et al.   BIOCONJUGATE CHEMISTRY

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

Carbohydrate-based amphiphilic nano delivery systems for cancer therapy

(2016) Kegang Liu et al.   Nanoscale

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

The Protein Corona of Plant Virus Nanoparticles Influences their Dispersion Properties, Cellular Interactions, and In Vivo Fates

(2016) Andrzej S. Pitek et al.   Small

Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma

(2016) Aniket S. Wadajkar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

(2016) Miriam Colombo et al.   Nature Communications

Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum

(2015) Shakiba Shahabi et al.   ACS Applied Materials & Interfaces

Enhancing Cellular Uptake and Doxorubicin Delivery of Mesoporous Silica Nanoparticles via Surface Functionalization: Effects of Serum

(2015) Shakiba Shahabi et al.   ACS Applied Materials & Interfaces

In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles

(2015) Marilena Hadjidemetriou et al.   ACS Nano

Development of a virus-mimicking nanocarrier for drug delivery systems: The bio-nanocapsule

(2015) Masaharu Somiya et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein corona hampers targeting potential of MUC1 aptamer functionalized SN-38 core–shell nanoparticles

(2015) Behrang Shiri Varnamkhasti et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Surface characterization and protein interaction of a series of model poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanocarriers for drug targeting

(2015) Sven Staufenbiel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liposome–protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines

(2015) Giulio Caracciolo   Nanomedicine-Nanotechnology Biology and Medicine

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

(2015) Qi Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

PEG-b-AGE polymer coated magnetic nanoparticle probes with facile functionalization and anti-fouling properties for reducing non-specific uptake and improving biomarker targeting

(2015) Yuancheng Li et al.   Journal of Materials Chemistry B

Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles

(2014) Alexandre Albanese et al.   ACS Nano

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting

(2014) Qin Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Size and charge of nanoparticles following incubation with human plasma of healthy and pancreatic cancer patients

(2014) Giulio Caracciolo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Advances in an active and passive targeting to tumor and adipose tissues

(2014) Yu Sakurai et al.   Expert Opinion on Drug Delivery

Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application

(2014) Huining He et al.   JOURNAL OF CONTROLLED RELEASE

State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines

(2014) Charlene M. Dawidczyk et al.   JOURNAL OF CONTROLLED RELEASE

The liposome–protein corona in mice and humans and its implications for in vivo delivery

(2014) G. Caracciolo et al.   Journal of Materials Chemistry B

Polymer-Coated Nanoparticles Interacting with Proteins and Cells: Focusing on the Sign of the Net Charge

(2013) Dominik Hühn et al.   ACS Nano

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Preformed albumin corona, a protective coating for nanoparticles based drug delivery system

(2013) Qiang Peng et al.   BIOMATERIALS

Protein corona significantly reduces active targeting yield

(2013) Vahid Mirshafiee et al.   CHEMICAL COMMUNICATIONS

Targeted delivery of platinum-based anticancer complexes

(2013) Jennifer S Butler et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Smart Targeting of Nanoparticles

(2013) Adam Friedman et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of poly(ethylene glycol) grafting density on the tumor targeting efficacy of nanoparticles with ligand modification

(2013) Shidong Zhang et al.   DRUG DELIVERY

Hyaluronic acid-coated chitosan nanoparticles: Molecular weight-dependent effects on morphology and hyaluronic acid presentation

(2013) Abdulaziz Almalik et al.   JOURNAL OF CONTROLLED RELEASE

Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy

(2013) Xin Li et al.   JOURNAL OF CONTROLLED RELEASE

‘Living’ PEGylation on gold nanoparticles to optimize cancer cell uptake by controlling targeting ligand and charge densities

(2013) Hongwei Chen et al.   NANOTECHNOLOGY

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities

(2012) Zeyu Xiao et al.   ACS Nano

Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN

(2012) Luis J. Cruz et al.   BIOMATERIALS

Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting

(2012) R. Seda Tığlı Aydın   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Physicochemical Characteristics of Protein–NP Bioconjugates: The Role of Particle Curvature and Solution Conditions on Human Serum Albumin Conformation and Fibrillogenesis Inhibition

(2012) Sonia Goy-López et al.   LANGMUIR

The Evolution of the Protein Corona around Nanoparticles: A Test Study

(2011) Martin Lundqvist et al.   ACS Nano

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

(2011) Yannan Zhao et al.   ACS Nano

Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems

(2011) Priya Prakash Karmali et al.   Expert Opinion on Drug Delivery

Nanoparticle delivery of a peptide targeting EGFR signaling

(2011) Sang Kyoon Kim et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The use of myristic acid as a ligand of polyethylenimine/DNA nanoparticles for targeted gene therapy of glioblastoma

(2011) Jin Li et al.   NANOTECHNOLOGY

Identification of serum proteins bound to industrial nanomaterials

(2011) Hermelindis Ruh et al.   TOXICOLOGY LETTERS

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles

(2008) Ashlynn L.Z. Lee et al.   BIOMATERIALS

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

(2008) Frank Alexis et al.   MOLECULAR PHARMACEUTICS

Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles

(2008) Marina A. Dobrovolskaia et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH