The point mutation of the cholesterol trafficking membrane protein NPC1 may affect its proper function in more than a single step: Molecular dynamics simulation study

Nanoscale slip length prediction with machine learning tools

(2021) Filippos Sofos et al.   Scientific Reports

Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective

(2021) Mikael B. L. Winkler et al.   FEBS LETTERS

High‐content imaging and structure‐based predictions reveal functional differences between Niemann‐Pick C1 variants

(2020) Lauri Vanharanta et al.   TRAFFIC

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

Cholesterol Transport in Wild-Type NPC1 and P691S: Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior

(2020) Nadia Elghobashi-Meinhardt   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

(2020) Piyali Saha et al.   eLife

Cholesterol metabolism: New functions and therapeutic approaches in cancer

(2020) Huanji Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

Exosome mimicry by a HAVCR1–NPC1 pathway of endosomal fusion mediates hepatitis A virus infection

(2020) Maria Isabel Costafreda et al.   Nature Microbiology

Molecular dynamics study with mutation shows that N‐terminal domain structural re‐orientation in Niemann‐Pick type C1 is required for proper alignment of cholesterol transport

(2020) Hye‐Jin Yoon et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain

(2020) Vikas Dubey et al.   PLoS Computational Biology

Computational Tools Unravel Putative Sterol Binding Sites in the Lysosomal NPC1 Protein

(2019) Nadia Elghobashi-Meinhardt   Journal of Chemical Information and Modeling

Structural basis of sterol recognition by human hedgehog receptor PTCH1

(2019) Chao Qi et al.   Science Advances

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

The characteristics and biological significance of NPC2: Mutation and disease

(2019) Yanan Xu et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

In silico direct folding of thrombin-binding aptamer G-quadruplex at all-atom level

(2017) Changwon Yang et al.   NUCLEIC ACIDS RESEARCH

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

(2017) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Structure of human Niemann–Pick C1 protein

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Types A and B Niemann-Pick disease

(2015) Edward H. Schuchman et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

(2015) X. Du et al.   BIOCHEMICAL JOURNAL

The life cycle of the low-density lipoprotein receptor

(2015) Melinde Wijers et al.   CURRENT OPINION IN LIPIDOLOGY

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

Fluid Flow at the Nanoscale: How Fluid Properties Deviate from the Bulk

(2013) Filippos Sofos et al.   Nanoscience and Nanotechnology Letters

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

(2011) M. S. Deffieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A structure-based benchmark for protein-protein binding affinity

(2011) Panagiotis L. Kastritis et al.   PROTEIN SCIENCE

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

(2010) Michael L. Wang et al.   Cell Metabolism

Molecular dynamics simulations of protein dynamics and their relevance to drug discovery

(2010) Freddie R Salsbury Jr   CURRENT OPINION IN PHARMACOLOGY