Cholesterol Transport in Wild-Type NPC1 and P691S: Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

Computational Tools Unravel Putative Sterol Binding Sites in the Lysosomal NPC1 Protein

(2019) Nadia Elghobashi-Meinhardt   Journal of Chemical Information and Modeling

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

Niemann–Pick type C disease: cellular pathology and pharmacotherapy

(2019) Simon Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process

(2019) Chao Wang et al.   Nature Communications

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways

(2018) Milan Hodošček et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

(2018) Michael Nguyen Trinh et al.   eLife

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

(2017) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

(2016) Michael N. Trinh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pKa Values in Proteins Determined by Electrostatics Applied to Molecular Dynamics Trajectories

(2015) Tim Meyer et al.   Journal of Chemical Theory and Computation

Analysis of Multidomain Protein Dynamics

(2015) Amitava Roy et al.   Journal of Chemical Theory and Computation

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

(2015) Feiran Lu et al.   eLife

Detection of Long-Range Concerted Motions in Protein by a Distance Covariance

(2012) Amitava Roy et al.   Journal of Chemical Theory and Computation

MOLEonline 2.0: interactive web-based analysis of biomacromolecular channels

(2012) K. Berka et al.   NUCLEIC ACIDS RESEARCH

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA