Targeting mitochondrial metabolism for precision medicine in cancer

A phase I study of intravenous fenretinide (4-HPR) for patients with malignant solid tumors

(2021) Jacob S. Thomas et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma

(2021) Peipei Han et al.   PATHOLOGY RESEARCH AND PRACTICE

Exploring the therapeutic potential of mitochondrial uncouplers in cancer

(2021) Riya Shrestha et al.   Molecular Metabolism

Low glycaemic diets alter lipid metabolism to influence tumour growth

(2021) Evan C. Lien et al.   NATURE

Pharmacological basis and new insights of deguelin concerning its anticancer effects

(2021) Zhu Yue Lin et al.   PHARMACOLOGICAL RESEARCH

Dual Inhibition of Pyruvate Dehydrogenase Complex and Respiratory Chain Complex Induces Apoptosis by a Mitochondria‐Targeted Fluorescent Organic Arsenical in vitro and in vivo

(2020) Yu‐Jiao Liu et al.   ChemMedChem

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation

(2020) Yibao Ma et al.   Scientific Reports

Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

(2020) Alok Kumar et al.   eLife

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

(2020) Juan C. García-Cañaveras et al.   LEUKEMIA

Targeting Fatty Acid Oxidation to Promote Anoikis and Inhibit Ovarian Cancer Progression

(2020) Brandon T. Sawyer et al.   MOLECULAR CANCER RESEARCH

Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement

(2020) Vaishali Aggarwal et al.   SEMINARS IN CANCER BIOLOGY

Inhibitors of Fatty Acid Synthesis and Oxidation as Potential Anticancer Agents in Colorectal Cancer Treatment

(2020) PAULINA MOZOLEWSKA et al.   ANTICANCER RESEARCH

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

(2020) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

(2020) Aamod S. Dekhne et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

(2020) Sabzali Javadov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism

(2019) Minjoong Kim et al.   ONCOGENE

Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

(2019) Ruoxi Hong et al.   Molecular Oncology

The role of thioredoxin system in cancer: strategy for cancer therapy

(2019) Jin-Jing Jia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT 2 by antifolate drugs

(2019) Emma Scaletti et al.   FEBS LETTERS

Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer

(2019) Subbroto Saha et al.   Journal of Clinical Medicine

Metformin in breast cancer: preclinical and clinical evidence

(2019) Anindita De et al.   CURRENT PROBLEMS IN CANCER

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy

(2019) Aamod S. Dekhne et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity

(2019) Junya Kawai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oncogenic pathways and the electron transport chain: a dangeROS liaison

(2019) Vittoria Raimondi et al.   BRITISH JOURNAL OF CANCER

Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects

(2019) Muhamad Noor Alfarizal Kamarudin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondria in cancer metabolism, an organelle whose time has come?

(2018) Rebecca G. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Treatment of Angina: Where Are We?

(2018) Cristina Balla et al.   CARDIOLOGY

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

(2018) Seungyeon Yang et al.   Cell Death & Disease

Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions

(2018) Xi Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy

(2018) Partha S. Chowdhury et al.   Cancer Immunology Research

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

(2017) Gregory S. Ducker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Mitochondrial mutations drive prostate cancer aggression

(2017) Julia F. Hopkins et al.   Nature Communications

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

(2017) Katharine Yen et al.   Cancer Discovery

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling

(2017) Yuan Cao et al.   Theranostics

The Glycolytic Switch in Tumors: How Many Players Are Involved?

(2017) Li Yu et al.   Journal of Cancer

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8+ T cell proliferation

(2016) Beom K Choi et al.   Cellular & Molecular Immunology

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

The importance of mitochondrial folate enzymes in human colorectal cancer

(2016) Masaaki Miyo et al.   ONCOLOGY REPORTS

A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma

(2016) Thomas W. Lycan et al.   PLoS One

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia

(2016) Jinlong Shi et al.   EBioMedicine

The molecular targets of resveratrol

(2015) Sameer S. Kulkarni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

(2015) H. Yang et al.   EMBO JOURNAL

Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer

(2015) Y. Ni et al.   ENDOCRINE-RELATED CANCER

Mitochondria: The ketogenic diet—A metabolism-based therapy

(2015) Silvia Vidali et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities

(2015) Matthias C. Witschel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer

(2015) Caifeng Xie et al.   Oncotarget

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

(2015) Laura Lehtinen et al.   Oncotarget

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

(2015) Yue-Zhi Lee et al.   Oncotarget

Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase

(2014) Nicola Sassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies

(2014) T. S. Pardee et al.   CLINICAL CANCER RESEARCH

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

(2014) A.M. Poff et al.   INTERNATIONAL JOURNAL OF CANCER

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Increased MTHFD2 expression is associated with poor prognosis in breast cancer

(2014) Feng Liu et al.   TUMOR BIOLOGY

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

(2013) Chia-Chi Hsu   WORLD JOURNAL OF GASTROENTEROLOGY

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

(2012) Antoine Italiano et al.   BMC CANCER

Overexpression of the Mitochondrial Folate and Glycine-Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

(2012) A. Vazquez et al.   CANCER RESEARCH

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

(2012) Krupa Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spectrum of somatic mitochondrial mutations in five cancers

(2012) T. C. Larman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

(2012) K. Thangavelu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

A ROS rheostat for cell fate regulation

(2012) Maria Maryanovich et al.   TRENDS IN CELL BIOLOGY

Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain

(2011) Jakub Rohlena et al.   ANTIOXIDANTS & REDOX SIGNALING

Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

(2011) Byron DeLaBarre et al.   BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

(2011) Alberto J. Montero et al.   DRUGS

Modulation of oxidative stress and mitochondrial function by the ketogenic diet

(2011) Julie Milder et al.   EPILEPSY RESEARCH

A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy

(2011) Ramesh K. Ramanathan et al.   INVESTIGATIONAL NEW DRUGS

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

(2010) Jean-Pierre Bayley et al.   LANCET ONCOLOGY

The Reverse Transcription Inhibitor Abacavir Shows Anticancer Activity in Prostate Cancer Cell Lines

(2010) Francesca Carlini et al.   PLoS One

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

(2009) C. Yang et al.   CANCER RESEARCH

Optimisation of Conoidin A, a Peroxiredoxin Inhibitor

(2009) Gu Liu et al.   ChemMedChem

Novel Inhibitors Complexed with Glutamate Dehydrogenase

(2009) Ming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketone bodies inhibit the viability of human neuroblastoma cells

(2009) Robert Skinner et al.   JOURNAL OF PEDIATRIC SURGERY

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors

(2007) Kaleb C. Lund et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY