Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

(2018) Seungyeon Yang et al.   Cell Death & Disease

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

(2017) Douglas E. Biancur et al.   Nature Communications

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth

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A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

(2017) Jun-Kyu Byun et al.   Cell Reports

Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells

(2016) Deven Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS homeostasis and metabolism: a dangerous liason in cancer cells

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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase

(2016) Kosuke Toda et al.   NEOPLASIA

Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition

(2016) Seung Min Jeong et al.   Scientific Reports

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

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Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

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Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Glutamine: pleiotropic roles in tumor growth and stress resistance

(2011) Naval P. Shanware et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA