Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

The p53 mRNA-Mdm2 interaction

(2011) Nadia Naski et al.   CELL CYCLE

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

(2009) Michelle R Arkin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects

(2008) David Lagorce et al.   BMC BIOINFORMATICS

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Pybel: a Python wrapper for the OpenBabel cheminformatics toolkit

(2008) Noel M O'Boyle et al.   Chemistry Central Journal

Machine Learning for In Silico Virtual Screening and Chemical Genomics: New Strategies

(2008) Jean-Philippe Vert et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks

(2008) Ozlem Keskin et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

In Silico-In Vitro Screening of Protein-Protein Interactions: Towards the Next Generation of Therapeutics

(2008) Bruno Villoutreix et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Drug-Like Inhibitors of Protein-Protein Interactions: A Structural Examination of Effective Protein Mimicry

(2008) D. Fry   CURRENT PROTEIN & PEPTIDE SCIENCE

Predicting druggable binding sites at the protein–protein interface

(2008) Jonathan C. Fuller et al.   DRUG DISCOVERY TODAY

What has virtual screening ever done for drug discovery?

(2008) David E Clark   Expert Opinion on Drug Discovery

Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer

(2008) Sharmila Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

What are decision trees?

(2008) Carl Kingsford et al.   NATURE BIOTECHNOLOGY

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA