Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis

(2017) Jurema Schmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)

(2017) David C. Tully et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nonacidic Farnesoid X Receptor Modulators

(2017) Daniel Flesch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery

(2017) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapies in non-alcoholic steatohepatitis (NASH)

(2017) Abdul M. Oseini et al.   LIVER INTERNATIONAL

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

NSAIDs Ibuprofen, Indometacin and Diclofenac do not interact with Farnesoid X Receptor

(2015) Jurema Schmidt et al.   Scientific Reports

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

(2014) Daniel Merk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities

(2014) Christian Gege et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Extending the Structure–Activity Relationship of Anthranilic Acid Derivatives As Farnesoid X Receptor Modulators: Development of a Highly Potent Partial Farnesoid X Receptor Agonist

(2014) Daniel Merk et al.   JOURNAL OF MEDICINAL CHEMISTRY

8-Benzamidochromen-4-one-2-carboxylic Acids: Potent and Selective Agonists for the Orphan G Protein-Coupled Receptor GPR35

(2013) Mario Funke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

(2012) Ramona Steri et al.   BIOCHEMICAL PHARMACOLOGY

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

(2012) Daniel Merk et al.   Future Medicinal Chemistry

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist

(2009) Song Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MBX-102/JNJ39659100, a Novel Peroxisome Proliferator-Activated Receptor-Ligand with Weak Transactivation Activity Retains Antidiabetic Properties in the Absence of Weight Gain and Edema

(2009) Francine M. Gregoire et al.   MOLECULAR ENDOCRINOLOGY

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

(2008) Paul Labute   JOURNAL OF COMPUTATIONAL CHEMISTRY