Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells

Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade

(2022) Malliga R. Iyer et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

(2022) Sandra Codony et al.   JOURNAL OF MEDICINAL CHEMISTRY

Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

(2021) Bruce D. Hammock et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues

(2021) Christophe Morisseau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics

(2021) Moritz Helmstädter et al.   JOURNAL OF MEDICINAL CHEMISTRY

GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans

(2021) James M. Luther et al.   HYPERTENSION

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors

(2021) Felix F. Lillich et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage

(2021) Ross P Martini et al.   Neurocritical Care

Importance of Quantifying Drug-Target Engagement in Cells

(2020) Jakub Stefaniak et al.   ACS Medicinal Chemistry Letters

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy

(2020) Mercè Pallàs et al.   Biomolecules

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

(2020) Christian Griñán-Ferré et al.   Neurotherapeutics

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease

(2020) Jérémie Gautheron et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

(2020) Anamitra Ghosh et al.   Science Translational Medicine

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases

(2019) Jogen Atone et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs

(2018) Leigh A. Stoddart et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

(2017) Anders Højgaard Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

(2017) Karen M. Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Phosphatase activity of soluble epoxide hydrolase

(2017) Jan Kramer et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Target Engagement in Lead Generation

(2015) Timothy B. Durham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

(2015) Eric Kowarz et al.   Biotechnology Journal

Photobleaching Kinetics and Time-Integrated Emission of Fluorescent Probes in Cellular Membranes

(2014) Daniel Wüstner et al.   MOLECULES

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

(2013) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor

(2013) Patricia L. Podolin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

(2010) Tristan E. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a High Throughput Cell-Based Assay for Soluble Epoxide Hydrolase Using BacMam Technology

(2010) Wensheng Xie et al.   MOLECULAR BIOTECHNOLOGY