Ligand‐Enabled β‐C(sp 3 )−H Lactamization of Tosyl‐Protected Aliphatic Amides Using a Practical Oxidant

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C–H/C–H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F

(2021) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Syntheses of Cyclic Anhydrides via Ligand‐Enabled C−H Carbonylation of Simple Aliphatic Acids

(2021) Jin-Quan Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition‐Metal‐Catalyzed Annulations Involving the Activation of C(sp 3 )−H Bonds

(2021) Marc Font et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)–H Lactamization of Native Amides

(2021) Shuang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled β-Methylene C(sp3)−H Arylation of Masked Aliphatic Alcohols

(2020) Guoqin Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Formal (4+2) Cycloaddition between Alkyl Amides and Dienes Initiated by the Activation of C(sp3)–H Bonds

(2020) Borja Cendón et al.   ACS Catalysis

From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C–H Functionalization Reactions

(2020) Qian Shao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ligand-Enabled Monoselective β-C(sp3)–H Acyloxylation of Free Carboxylic Acids Using a Practical Oxidant

(2020) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzed Enantioselective γ-C(sp3)–H Functionalizations of Free Cyclopropylmethylamines

(2020) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines

(2019) Chuan He et al.   Chem

Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp 3 )–H Bonds

(2019) Tao Zhou et al.   CHINESE JOURNAL OF CHEMISTRY

Lactonization as a general route to β-C(sp3)–H functionalization

(2019) Zhe Zhuang et al.   NATURE

Asymmetric Synthesis of β-Lactam via Palladium-Catalyzed Enantioselective Intramolecular C(sp3)–H Amidation

(2019) Hua-Rong Tong et al.   ACS Catalysis

Pd-Catalyzed Acetoxylation of γ-C(sp3)–H Bonds of Amines Directed by a Removable Bts-Protecting Group

(2018) Yong Zheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-Enabled β-C(sp3)–H Olefination of Free Carboxylic Acids

(2018) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis and chemical diversity of β-lactone natural products

(2018) Serina L. Robinson et al.   NATURAL PRODUCT REPORTS

Recent advances in β-lactam synthesis

(2018) Seyedmorteza Hosseyni et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Overcoming the Limitations of γ- and δ-C–H Arylation of Amines through Ligand Development

(2018) Yan-Qiao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams

(2017) Lena Decuyper et al.   MEDICINAL RESEARCH REVIEWS

Formation of α-chiral centers by asymmetric β-C(sp 3 )–H arylation, alkenylation, and alkynylation

(2017) Qing-Feng Wu et al.   SCIENCE

Ligand-Enabled γ-C(sp3)–H Cross-Coupling of Nosyl-Protected Amines with Aryl- and Alkylboron Reagents

(2017) Qian Shao et al.   ACS Catalysis

Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)–H Bonds with Azodiformates via Bidentate-Chelation Assistance

(2017) He-Yuan Bai et al.   ACS Catalysis

Synthesis of 2,2′-biphenols through direct C(sp2)–H hydroxylation of [1,1′-biphenyl]-2-ols

(2016) Shitao Duan et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Stereoselective Synthesis of Diazabicyclic β-Lactams through Intramolecular Amination of Unactivated C(sp3)–H Bonds of Carboxamides by Palladium Catalysis

(2016) Shi-Jin Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-accelerated enantioselective methylene C(sp3)–H bond activation

(2016) Gang Chen et al.   SCIENCE

A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams

(2016) Darren Willcox et al.   SCIENCE

Nickel-Catalyzed Reaction of C–H Bonds in Amides with I2: ortho-Iodination via the Cleavage of C(sp2)–H Bonds and Oxidative Cyclization to β-Lactams via the Cleavage of C(sp3)–H Bonds

(2016) Yoshinori Aihara et al.   ACS Catalysis

Palladium(0)/PAr3-Catalyzed Intermolecular Amination of C(sp3)H Bonds: Synthesis of β-Amino Acids

(2015) Jian He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N -Sulfonyl-β-lactam hapten as an effective labeling reagent for aldolase mAb

(2015) Tsubasa Inokuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PdII-Catalyzed Intermolecular Amination of Unactivated C(sp3)H Bonds

(2015) Quan Gou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis

(2015) Joseph J. Topczewski et al.   Chemical Science

Cobalt-catalysed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons

(2015) Xuesong Wu et al.   Nature Communications

Access to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp3)H Alkylation

(2014) Julia Pedroni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Intramolecular C(sp3)H and C(sp2)H Amidation by Oxidative Cyclization

(2014) Zhen Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Site-Selective Intramolecular Amidation of Unactivated C(sp3)H Bonds

(2014) Xuesong Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of β-Lactams: Asymmetric Catalysis and Other Recent Advances

(2014) Cody Ross Pitts et al.   CHEMICAL REVIEWS

Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp3)H Bonds

(2014) Xuesong Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

2,2,2-Trifluoroethanol as Green Solvent in Organic Synthesis: A Review

(2014) Anshu Dandia et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Ligand-Controlled C(sp3)-H Arylation and Olefination in Synthesis of Unnatural Chiral  -Amino Acids

(2014) J. He et al.   SCIENCE

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carboxylic Acid (Bio)Isosteres in Drug Design

(2013) Carlo Ballatore et al.   ChemMedChem

Palladium-Catalyzed Unactivated C(sp3)–H Bond Activation and Intramolecular Amination of Carboxamides: A New Approach to β-Lactams

(2013) Wen-Wu Sun et al.   ORGANIC LETTERS

Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst

(2012) Masayuki Wasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bystanding F+ Oxidants Enable Selective Reductive Elimination from High-Valent Metal Centers in Catalysis

(2011) Keary M. Engle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monocyclic β-Lactams: New Structures for New Biological Activities

(2011) P. Galletti et al.   CURRENT MEDICINAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Cyclization of 2-Arylphenols to Dibenzofurans under Pd(II)/Peroxybenzoate Catalysis

(2011) Ye Wei et al.   ORGANIC LETTERS

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

(2010) Olivier A. Pierrat et al.   ACS Chemical Biology

Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis

(2010) Petr Sehnal et al.   CHEMICAL REVIEWS

2-Azetidinone – A new profile of various pharmacological activities

(2010) Parul D. Mehta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pd(II)-Catalyzed Carbonylation of C(sp3)−H Bonds: A New Entry to 1,4-Dicarbonyl Compounds

(2010) Eun Jeong Yoo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzedo-C−H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O

(2010) Chris J. Vickers et al.   ORGANIC LETTERS

Organopalladium(iv) chemistry

(2009) Ling-Min Xu et al.   CHEMICAL SOCIETY REVIEWS

Novel Syntheses of Azetidines and Azetidinones

(2008) Alberto Brandi et al.   CHEMICAL REVIEWS

Convergent Synthesis of (2R,3R,8R,9R)-N-Boc-ADDA

(2008) Sebastien Meiries et al.   JOURNAL OF ORGANIC CHEMISTRY