NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

Pathogenesis of amyotrophic lateral sclerosis

(2016) Sarah Morgan et al.   BRITISH MEDICAL BULLETIN

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms

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Role of neuroinflammation in neurodegenerative diseases (Review)

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Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice

(2016) Marius Heitzer et al.   MOLECULAR NEUROBIOLOGY

Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease

(2016) Pei Zhang et al.   MOVEMENT DISORDERS

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

(2016) Massimiliano De Paola et al.   PHARMACOLOGICAL RESEARCH

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Biological role of Toll-like receptor-4 in the brain

(2014) Teresa Trotta et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

(2014) Paola Italiani et al.   Journal of Neuroinflammation

Inflammasomes in the CNS

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Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

(2013) Philippe Corcia et al.   PLoS One

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

(2012) Johannes Brettschneider et al.   PLoS One

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1

(2010) J Aebischer et al.   CELL DEATH AND DIFFERENTIATION

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

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Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

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Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice

(2008) Rebecca Banerjee et al.   PLoS One

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING