Syntaxin binding mechanism and disease-causing mutations in Munc18-2

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

(2013) A. M. James et al.   BLOOD

Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*

(2013) Richard W. Baker et al.   PLoS One

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation

(2013) N.-R. Bin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

(2013) S. C. Graham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Munc18b/STXBP2 is required for platelet secretion

(2012) R. Al Hawas et al.   BLOOD

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion

(2012) S. Ye et al.   BLOOD

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

(2012) Y. T. Bryceson et al.   BLOOD

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

(2012) Marieke Meijer et al.   EMBO JOURNAL

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

Syntaxin 11 is required for NK and CD8+T-cell cytotoxicity and neutrophil degranulation

(2012) Orietta D'Orlando et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel mutation in STXBP2 prevents IL-2–induced natural killer cell cytotoxicity

(2012) Rushani W. Saltzman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

(2012) Eunjin Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

(2012) M. P. Christie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Resolving the Function of Distinct Munc18-1/SNARE Protein Interaction Modes in a Reconstituted Membrane Fusion Assay

(2011) Yvette Schollmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex

(2011) Lei Shi et al.   MOLECULAR BIOLOGY OF THE CELL

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Munc18b regulates core SNARE complex assembly and constitutive exocytosis by interacting with the N-peptide and the closed-conformation C-terminus of syntaxin 3

(2010) Ren-Wang Peng et al.   BIOCHEMICAL JOURNAL

Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle

(2010) Yi Xu et al.   BIOCHEMISTRY

Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2

(2010) M. Meeths et al.   BLOOD

At the junction of SNARE and SM protein function

(2010) Chavela M Carr et al.   CURRENT OPINION IN CELL BIOLOGY

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion

(2010) Jingshi Shen et al.   JOURNAL OF CELL BIOLOGY

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

(2010) V. Cetica et al.   JOURNAL OF MEDICAL GENETICS

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

(2010) S. S. Rathore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

(2010) S.-H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

(2009) Charles Simon Bond et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Abrogating Munc18-1-SNARE Complex Interaction Has Limited Impact on Exocytosis in PC12 Cells

(2009) Nancy T. Malintan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

(2009) Ferenc Deák et al.   JOURNAL OF CELL BIOLOGY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission inCaenorhabditis elegans

(2008) James R. Johnson et al.   BIOCHEMICAL JOURNAL

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL

A Random Mutagenesis Approach to Isolate Dominant-Negative Yeast sec1 Mutants Reveals a Functional Role for Domain 3a in Yeast and Mammalian Sec1/Munc18 Proteins

(2008) A. Boyd et al.   GENETICS

UNC-18 Promotes Both the Anterograde Trafficking and Synaptic Function of Syntaxin

(2008) Jason M. McEwen et al.   MOLECULAR BIOLOGY OF THE CELL

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC