Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Cell Cycle-Related Acquisition of Cytotoxic Mediators Defines the Progressive Differentiation to Effector Status for Virus-Specific CD8+ T Cells

(2014) M. R. Jenkins et al.   JOURNAL OF IMMUNOLOGY

Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning

(2014) Elena Sieni et al.   Frontiers in Immunology

Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells

(2013) C. E. Terrell et al.   BLOOD

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

(2013) O Susanto et al.   CELL DEATH AND DIFFERENTIATION

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

(2013) J. A. Lopez et al.   JOURNAL OF IMMUNOLOGY

Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells

(2013) P. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function

(2013) Ilia Voskoboinik et al.   Frontiers in Immunology

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

(2012) V R Sutton et al.   Cell Death & Disease

In vivo evidence for dendritic cell lysis by NK cells: Hints on improving cancer vaccines by targeting NK cell activation

(2012) Guido Ferlazzo   OncoImmunology

Familial and Acquired Hemophagocytic Lymphohistiocytosis

(2011) G.E. Janka   Annual Review of Medicine

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes

(2011) Kateřina Kuželová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Critical Role for Granzymes in Antigen Cross-Presentation through Regulating Phagocytosis of Killed Tumor Cells

(2011) S. Hoves et al.   JOURNAL OF IMMUNOLOGY

The synapse and cytolytic machinery of cytotoxic T cells

(2010) Misty R Jenkins et al.   CURRENT OPINION IN IMMUNOLOGY

Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice

(2009) Jana Pachlopnik Schmid et al.   EMBO Molecular Medicine

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection

(2009) G. Yeretssian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

(2008) K A Sedelies et al.   CELL DEATH AND DIFFERENTIATION

Cytotoxic T-lymphocyte–mediated killing of human pancreatic islet cells in vitro

(2008) Peter D. Campbell et al.   HUMAN IMMUNOLOGY

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER