The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

Inherited defects in lymphocyte cytotoxic activity

(2015) Jana P. Schmid et al.   IMMUNOLOGICAL REVIEWS

Munc13-4 Regulates Granule Secretion in Human Neutrophils

(2014) C. Pivot-Pajot et al.   JOURNAL OF IMMUNOLOGY

Doc2  and Munc13-4 Regulate Ca2+-Dependent Secretory Lysosome Exocytosis in Mast Cells

(2014) H. Higashio et al.   JOURNAL OF IMMUNOLOGY

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

(2010) Q. Ren et al.   BLOOD

Structure and mechanism in membrane trafficking

(2010) Frederick M Hughson et al.   CURRENT OPINION IN CELL BIOLOGY

Munc13-4 Restricts Motility of Rab27a-expressing Vesicles to Facilitate Lipopolysaccharide-induced Priming of Exocytosis in Neutrophils

(2010) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunological synapse: a focal point for endocytosis and exocytosis

(2010) Gillian M. Griffiths et al.   JOURNAL OF CELL BIOLOGY

The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation

(2010) R. Dressel et al.   JOURNAL OF IMMUNOLOGY

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes

(2010) Casper C. Hoogenraad et al.   PLOS BIOLOGY

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

(2009) Cédric Delevoye et al.   JOURNAL OF CELL BIOLOGY

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

A Protein Interaction Node at the Neurotransmitter Release Site: Domains of Aczonin/Piccolo, Bassoon, CAST, and Rim Converge on the N-Terminal Domain of Munc13-1

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

(2008) G. Menasche et al.   BLOOD

Shouts, whispers and the kiss of death: directional secretion in T cells

(2008) Morgan Huse et al.   NATURE IMMUNOLOGY

Modulating Vesicle Priming Reveals that Vesicle Immobilization Is Necessary but not Sufficient for Fusion-Competence

(2008) Ofer Yizhar et al.   PLoS One

Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells

(2008) P. Khandelwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key Determinants of Rab Specificity

(2008) Aymelt Itzen et al.   STRUCTURE

Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex

(2008) Keith Weninger et al.   STRUCTURE

Structural Basis for the Exclusive Specificity of Slac2-a/Melanophilin for the Rab27 GTPases

(2008) Mutsuko Kukimoto-Niino et al.   STRUCTURE

Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a

(2008) Leonard M.G. Chavas et al.   STRUCTURE

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

(2008) Oliver Holt et al.   TRAFFIC

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules

(2008) Agnieszka A. Brzezinska et al.   TRAFFIC