Therapeutic Targets in Allergic Conjunctivitis

Reproxalap Improves Signs and Symptoms of Allergic Conjunctivitis in an Allergen Chamber: A Real-World Model of Allergen Exposure

(2022) David Clark et al.   Clinical Ophthalmology

Efficacy of once-daily ophthalmic bilastine for the treatment of allergic conjunctivitis: a dose-finding study

(2022) PJ Gomes et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

A Randomized Double-Masked Phase 2a Trial to Evaluate Activity and Safety of Topical Ocular Reproxalap, a Novel RASP Inhibitor, in Dry Eye Disease

(2021) David Clark et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Phase 3 Randomized Study of Efficacy and Safety of a Dexamethasone Intracanalicular Insert in Patients With Allergic Conjunctivitis

(2021) Eugene B. McLaurin et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Clinically Relevant Activity of the Novel RASP Inhibitor Reproxalap in Allergic Conjunctivitis: The Phase 3 ALLEVIATE Trial

(2021) David Clark et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis

(2021) Ting Shen et al.   Drug Design Development and Therapy

Effects of omalizumab on allergic conjunctivitis

(2021) E. Kırıkkaya et al.   INTERNATIONAL OPHTHALMOLOGY

Immunopharmacology in Vernal Keratoconjunctivitis: Current and Future Perspectives

(2021) DeGaulle I. Chigbu et al.   Pharmaceuticals

FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice

(2021) Jia-Jie Chen et al.   BIOCHEMICAL PHARMACOLOGY

Formulation and Pathohistological Study of Mizolastine–Solid Lipid Nanoparticles–Loaded Ocular Hydrogels

(2021) Ghada Ahmed El-Emam et al.   International Journal of Nanomedicine

Conditioned Medium of Human Amniotic Epithelial Cells Alleviates Experimental Allergic Conjunctivitis Mainly by IL-1ra and IL-10

(2021) Binxin Wu et al.   Frontiers in Immunology

Novel Polyvinyl Pyrrolidone–Loaded Olopatadine HCl–Laden Doughnut Contact Lens to Treat Allergic Conjunctivitis

(2020) Yushun Xue et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

FAK-Dependent Cell Motility and Cell Elongation

(2020) Kazuo Katoh   Cells

A contemporary look at allergic conjunctivitis

(2020) Pascale Dupuis et al.   Allergy Asthma and Clinical Immunology

Understanding the mechanisms that facilitate specificity, not redundancy, of chemokine‐mediated leukocyte recruitment

(2020) Douglas P. Dyer   IMMUNOLOGY

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

(2020) Kijeong Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokines in allergic conjunctivitis

(2020) Nir Erdinest et al.   Current Opinion in Allergy and Clinical Immunology

Tofacitinib suppresses mast cell degranulation and attenuates experimental allergic conjunctivitis

(2020) Yingqi Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Randomized Phase 2 Trial of Reproxalap, a Novel Reactive Aldehyde Species Inhibitor, in Patients with Noninfectious Anterior Uveitis: Model for Corticosteroid Replacement

(2020) Kenneth J. Mandell et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

In vitro and in vivo performance of epinastine hydrochloride-releasing contact lenses

(2019) Takahiro Minami et al.   PLoS One

Emerging Therapeutics for Ocular Surface Disease

(2019) Leonard Bielory et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Dupilumab after the 2017 approval for the treatment of atopic dermatitis

(2019) Jorien van der Schaft et al.   Current Opinion in Allergy and Clinical Immunology

Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens

(2019) Brian Pall et al.   CORNEA

Effects of combination of mizolastine and proteoglycan on chronic urticaria: a randomized controlled trial

(2019) Xing Xiong et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Dupilumab-induced ocular surface disease (DIOSD) in patients with atopic dermatitis: clinical presentation, risk factors for development and outcomes of treatment with tacrolimus ointment

(2019) Yoav Nahum et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Mesenchymal stem cells in allergic diseases: Current status

(2019) He Li et al.   ALLERGOLOGY INTERNATIONAL

More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages

(2019) Jan M. Ehrchen et al.   Frontiers in Immunology

Therapeutic Potential of Human Amniotic Epithelial Cells on Injuries and Disorders in the Central Nervous System

(2019) Huiming Xu et al.   Stem Cells International

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

Conjunctivitis occurring in atopic dermatitis patients treated with dupilumab-clinical characteristics and treatment

(2018) Andreas Wollenberg et al.   Journal of Allergy and Clinical Immunology-In Practice

Tofacitinib for the treatment of psoriasis and psoriatic arthritis

(2018) Anna Berekmeri et al.   Expert Review of Clinical Immunology

OUP accepted manuscript

(2018)   RHEUMATOLOGY

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

(2018) Elden Berla Thangam et al.   Frontiers in Immunology

A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: The VEKTIS Study

(2018) Andrea Leonardi et al.   OPHTHALMOLOGY

Vernal Keratoconjunctivitis

(2018) Deepali Singhal et al.   SURVEY OF OPHTHALMOLOGY

Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease

(2017) Michael H. Goldstein et al.   Eye & Contact Lens-Science and Clinical Practice

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Gene-Environment Interaction in Childhood Asthma

(2017) L Rigoli et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Conjunctival allergen provocation test : guidelines for daily practice

(2016) J.-L. Fauquert et al.   ALLERGY

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

(2016) S. G. Royce et al.   CLINICAL SCIENCE

Topical delivery of aqueous micellar resolvin E1 analog (RX-10045)

(2016) Kishore Cholkar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A histamine-independent itch pathway is required for allergic ocular itch

(2016) Cheng-Chiu Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis

(2016) Chuan-Hui Kuo et al.   JOURNAL OF IMMUNOLOGY

TRPV1 Antagonist Suppresses Allergic Conjunctivitis in a Murine Model

(2016) Ji Young Kwon et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis

(2016) Ka Wai Kam et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Omalizumab Treatment of Vernal Keratoconjunctivitis

(2016) Enrico Heffler et al.   JAMA Ophthalmology

Mast Cell: A Multi-Functional Master Cell

(2016) Melissa Krystel-Whittemore et al.   Frontiers in Immunology

Stem Cell Therapies in Clinical Trials: Progress and Challenges

(2015) Alan Trounson et al.   Cell Stem Cell

Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease

(2015) Joseph Tauber et al.   OPHTHALMOLOGY

Ocular transient receptor potential channel function in health and disease

(2015) Peter S. Reinach et al.   BMC Ophthalmology

Cumulative Use of Strong Anticholinergics and Incident Dementia

(2015) Shelly L. Gray et al.   JAMA Internal Medicine

The role of leukotrienes in allergic diseases

(2015) Min Liu et al.   ALLERGOLOGY INTERNATIONAL

Total IgE and eotaxin (CCL11) contents in tears of patients suffering from seasonal allergic conjunctivitis

(2014) Simone Eperon et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Functional characterization of histamine H4 receptor on human mast cells

(2014) E. Angel Jemima et al.   MOLECULAR IMMUNOLOGY

Retrospective Review on the Use of Topical Cyclosporin A 0.05% for Paediatric Allergic Conjunctivitis in Hong Kong Chinese

(2014) Macy M. S. Wu et al.   TheScientificWorldJOURNAL

Comparison of the efficacy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model

(2014) Mete Kaan BOZKURT et al.   Turkish Journal Of Medical Sciences

Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy

(2014) Santi Spampinato et al.   Drug Design Development and Therapy

Adoptive Transfer of Human Gingiva-Derived Mesenchymal Stem Cells Ameliorates Collagen-Induced Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of Regulatory T Cell Differentiation

(2013) Maogen Chen et al.   ARTHRITIS AND RHEUMATISM

Twenty-first century mast cell stabilizers

(2013) D F Finn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Specific IgE in Tear Fluid and Features of Allergic Conjunctivitis

(2013) Tatsuya Mimura et al.   CURRENT EYE RESEARCH

Allergic conjunctivitis

(2013) Terrence P. O’Brien   Current Opinion in Allergy and Clinical Immunology

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

Conjunctivitis

(2013) Amir A. Azari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab

(2013) Timothy A. de Klerk et al.   JOURNAL OF AAPOS

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis

(2013) Vaidehi Garg et al.   MEDICAL HYPOTHESES

Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye Disease

(2013) Francisco Amparo et al.   JAMA Ophthalmology

Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface

(2012) A. Leonardi et al.   ALLERGY

Environmental assessment and exposure control: a practice parameter—furry animals

(2012) Jay M. Portnoy et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

State of the art paper T lymphocytes as a target of histamine action

(2012) Tomasz Kmiecik et al.   Archives of Medical Science

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis

(2012) Makiko Ohshima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunoregulation on the Ocular Surface: 2nd Cullen Symposium

(2012) Stephen C. Pflugfelder et al.   Ocular Surface

Leukotriene Receptor Antagonists in Allergic Eye Disease: A Systematic Review and Meta-analysis

(2012) Jennie Gane et al.   Journal of Allergy and Clinical Immunology-In Practice

Management of seasonal allergic conjunctivitis: guide to therapy

(2011) Brett P. Bielory et al.   ACTA OPHTHALMOLOGICA

Targeting the Histamine H4Receptor

(2011) Charles M. Marson   CHEMICAL REVIEWS

Epidemiology of allergic conjunctivitis

(2011) Nelson Rosario et al.   Current Opinion in Allergy and Clinical Immunology

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Histamine H4 Receptor: A Novel Target for Inflammation Therapy

(2011) C. Saravanan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cytokine and chemokine levels in tears from healthy subjects

(2010) Ester Carreño et al.   ACTA OPHTHALMOLOGICA

Multicenter Clinical Evaluation of Bepotastine Besilate Ophthalmic Solutions 1.0% and 1.5% to Treat Allergic Conjunctivitis

(2010) Thomas T. Macejko et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Histamina, receptores de histamina e anti-histamínicos: novos conceitos

(2010) Paulo Ricardo Criado et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

New Developments in the Use of Histamine and Histamine Receptors

(2010) Craig Smuda et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Allergic Conjunctivitis and the Impact of Allergic Rhinitis

(2010) Leonard Bielory   CURRENT ALLERGY AND ASTHMA REPORTS

Targeting inflammation using selective glucocorticoid receptor modulators

(2010) Karolien De Bosscher et al.   CURRENT OPINION IN PHARMACOLOGY

Dendritic cell physiology and function in the eye

(2010) John V. Forrester et al.   IMMUNOLOGICAL REVIEWS

Immunochromatographic Assay for Measurement of Total IgE in Tears, Nasal Mucus, and Saliva of Patients with Allergic Rhinoconjunctivitis

(2010) Tatsuya Mimura et al.   JOURNAL OF ASTHMA

The Role of the CCL2/CCR2 Axis in Mouse Mast Cell Migration In Vitro and In Vivo

(2010) S. J. Collington et al.   JOURNAL OF IMMUNOLOGY

Histamine H4 Receptor: A Novel Therapeutic Target for Immune and Allergic Responses

(2010) H. G. Bhatt et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mometasone furoate improves nasal and ocular symptoms of seasonal allergic rhinitis in adolescents

(2009) Robert Anolik et al.   ALLERGY AND ASTHMA PROCEEDINGS

Fluticasone furoate nasal spray is more effective than fexofenadine for nighttime symptoms of seasonal allergy

(2009) Charles P. Andrews et al.   ALLERGY AND ASTHMA PROCEEDINGS

Immunomodulation of Allergic Disease

(2009) David H. Broide   Annual Review of Medicine

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

(2009) H Schäcke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Time to onset and duration of action of the antihistamine bepotastine besilate ophthalmic solutions 1.0% and 1.5% in allergic conjunctivitis: A phase III, single-center, prospective, randomized, double-masked, placebo-controlled, conjunctival allergen challenge assessment in adults and children

(2009) Mark B. Abelson et al.   CLINICAL THERAPEUTICS

Multiple Cytokine Analysis in Human Tears: An Optimized Procedure for Cytometric Bead-Based Assay

(2009) Martin W. LaFrance et al.   CURRENT EYE RESEARCH

Leukocyte integrins and their ligand interactions

(2009) Young-Min Hyun et al.   IMMUNOLOGIC RESEARCH

The management of allergic eye diseases in primary eye care

(2009) DeGaulle I. Chigbu   Contact Lens & Anterior Eye

Giant papillary conjunctivitis

(2008) William H Elhers et al.   Current Opinion in Allergy and Clinical Immunology

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

Ocular Allergy Overview

(2008) Leonard Bielory   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

The pathophysiology of ocular allergy: A review

(2008) De Gaulle I. Chigbu   Contact Lens & Anterior Eye

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

(2007) Nilesh M. Kalariya et al.   EXPERIMENTAL EYE RESEARCH