FAK inhibitor PF-431396 suppresses IgE-mediated mast cell activation and allergic inflammation in mice

Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis

(2021) Hui-Na Wang et al.   Journal of Translational Medicine

Aurora kinase inhibitor tozasertib suppresses mast cell activation in vitro and in vivo

(2020) Li‐Na Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

FAK-Dependent Cell Motility and Cell Elongation

(2020) Kazuo Katoh   Cells

The antipsychotic drug pimozide inhibits IgE-mediated mast cell degranulation and migration

(2020) Yi-Bo Hou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA

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Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca2+/CAMK II/ERK/NF-κB signaling pathway

(2019) Xiao-wei Ding et al.   ACTA PHARMACOLOGICA SINICA

Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling

(2019) Shuilian Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis

(2019) Yuanyuan Ding et al.   FOOD AND CHEMICAL TOXICOLOGY

Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn

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Rapamycin attenuates Th2-driven experimental allergic conjunctivitis

(2018) Soojung Shin et al.   CLINICAL IMMUNOLOGY

Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma

(2017) Angie S. Morris et al.   MOLECULAR PHARMACEUTICS

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Glucocorticoid resistance in chronic diseases

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Emerging concepts: mast cell involvement in allergic diseases

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Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells

(2016) Mengna Chi et al.   Scientific Reports

Mast Cell Function

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Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

(2014) Pietro Ciceri et al.   Nature Chemical Biology

Oxidative activation of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis

(2014) Linda J. Zhu et al.   VASCULAR PHARMACOLOGY

IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma

(2013) Sejal Saglani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current Understanding of the Molecular Biology of Pancreatic Neuroendocrine Tumors

(2013) Jianliang Zhang et al.   JNCI-Journal of the National Cancer Institute

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

(2013) Hiroki Kabata et al.   Nature Communications

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Integrin α5 interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis

(2011) Youngmi Kim et al.   MOLECULAR IMMUNOLOGY

CaMKII in the Cardiovascular System: Sensing Redox States

(2011) Jeffrey R. Erickson et al.   PHYSIOLOGICAL REVIEWS

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: Implications for regulation of IgE-mediated degranulation

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Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma

(2009) P. Bhavsar et al.   EUROPEAN RESPIRATORY JOURNAL

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading

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A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma

(2008) P Bhavsar et al.   THORAX

The pathophysiology of ocular allergy: A review

(2008) De Gaulle I. Chigbu   Contact Lens & Anterior Eye