Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review

PD-L1, TMB, MSI, and Other Predictors of Response to Immune Checkpoint Inhibitors in Biliary Tract Cancer

(2021) Alessandro Rizzo et al.   Cancers

STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy

(2020) Sruthi V. Hindupur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential of Zerumbone as an Anti-Cancer Agent

(2019) Sosmitha Girisa et al.   MOLECULES

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

(2019) So-Yeon Park et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MiR-26a-5p potentiates metastasis of human lung cancer cells by regulating ITGβ8- JAK2/STAT3 axis

(2018) Qianqian Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma

(2018) Yubing Wang et al.   CANCER LETTERS

The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer

(2018) Xueqing Liu et al.   CANCER LETTERS

Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

(2018) Kaili Liu et al.   CANCER SCIENCE

The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I

(2018) Xiu-Qiong Fu et al.   EXPERIMENTAL DERMATOLOGY

Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway

(2018) Ning Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells

(2018) Huimin Wang et al.   MOLECULAR CARCINOGENESIS

JAK2/STAT3 pathway as a therapeutic target in ovarian cancers

(2018) Tomoyuki Yoshikawa et al.   Oncology Letters

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

(2018) Tony Eight Lin et al.   Frontiers in Pharmacology

A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells

(2017) Weixi Shen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

(2017) Bernd Groner et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inhibition of JAK2/STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer

(2017) Jian-Feng Liu et al.   MOLECULAR CARCINOGENESIS

STAT3 inhibition by WP1066 suppresses the growth and invasiveness of bladder cancer cells

(2017) Yujiro Tsujita et al.   ONCOLOGY REPORTS

SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway

(2017) Jianmei Zhou et al.   ONCOLOGY REPORTS

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response

(2017) Dunwei Guo et al.   Oncotarget

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

(2017) Ke-Jia Wu et al.   PLoS One

miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis

(2016) Weiguo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway

(2016) Chenlu Yang et al.   LABORATORY INVESTIGATION

Eriocalyxin B blocks human SW1116 colon cancer cell proliferation, migration, invasion, cell cycle progression and angiogenesis via the JAK2/STAT3 signaling pathway

(2016) YUN-MIN LU et al.   Molecular Medicine Reports

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer

(2016) H Zhang et al.   ONCOGENE

The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells

(2016) Dongmei Zhu et al.   TOXICOLOGY LETTERS

Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells

(2016) Thangaiyan Rabi et al.   TUMOR BIOLOGY

Sunitinib: the antiangiogenic effects and beyond

(2016) Zhonglin Hao et al.   OncoTargets and Therapy

Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway

(2016) Jinghua Wu et al.   Oncology Letters

Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway

(2016) Zubin Zhang et al.   Oncotarget

MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma

(2016) Hsuan-Yu Peng et al.   PLoS One

Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity

(2015) Jessica E. Jorvig et al.   ANTI-CANCER DRUGS

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

IL17 Functions through the Novel REG3 -JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

(2015) C. Loncle et al.   CANCER RESEARCH

Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells

(2015) PRAMOD DARVIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres

(2015) Rajesh Mukthavaram et al.   Journal of Translational Medicine

Novel quinazoline derivatives exhibit antitumor activity by inhibiting JAK2/STAT3

(2015) HAISHI QIAO et al.   ONCOLOGY REPORTS

Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway

(2015) LICHUAN WU et al.   ONCOLOGY REPORTS

Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer

(2015) Min Soo Kim et al.   Oncotarget

Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway

(2015) Xuan Liu et al.   PLoS One

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy

(2014) Fiona Tan et al.   CURRENT DRUG TARGETS

Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops

(2014) Viktoria Manstein et al.   Current Signal Transduction Therapy

Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway

(2014) YOUN HEE JOUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers

(2014) Ahmed Katsha et al.   Molecular Oncology

STAT3 Inhibitors: Finding a Home in Lymphoma and Leukemia

(2014) J. Munoz et al.   ONCOLOGIST

MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2

(2014) SILIANG WANG et al.   ONCOLOGY REPORTS

Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro

(2014) VENHAR GURBUZ et al.   Oncology Letters

The Role of STAT3 in Non-Small Cell Lung Cancer

(2014) Daijiro Harada et al.   Cancers

Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells

(2013) Wei Xu et al.   CANCER LETTERS

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

Hospicells promote upregulation of the ATP-binding cassette genes by insulin-like growth factor-I via the JAK2/STAT3 signaling pathway in an ovarian cancer cell line

(2013) NADIA BENABBOU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

(2013) Xiuting Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway

(2013) Yanwu Liu et al.   TOXICOLOGY

MiR-135a targetsJAK2and inhibits gastric cancer cell proliferation

(2012) Hao Wu et al.   CANCER BIOLOGY & THERAPY

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Leukotriene B4Receptor-2 Promotes Invasiveness and Metastasis of Ovarian Cancer Cells through Signal Transducer and Activator of Transcription 3 (STAT3)-dependent Up-regulation of Matrix Metalloproteinase 2

(2012) Ji-Min Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

(2012) Brendan D. Looyenga et al.   PLoS One

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

(2012) Jing-Xuan Pan et al.   Chinese Journal of Cancer

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

The Use of Structural Biology in Janus Kinase Targeted Drug Discovery

(2011) Nilda L. Alicea-Velazquez et al.   CURRENT DRUG TARGETS

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

(2008) Chun-Liang Chen et al.   Molecular Cancer

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE