The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
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Title
The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
Authors
Keywords
Colorectal cancer (CRC), Radioresistance, Janus kinase 2 (JAK2), Signal transducer and activator of transcription 3 (STAT3), Cyclin D2 (CCND2), Cancer stem cells (CSCs)
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-09-11
DOI
10.1186/s13046-019-1405-7
References
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- Cancer Stem Cell Niche: The Place to Be
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