Inhibition of JAK2/STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer

T-cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer

(2017) Jian-Feng Liu et al.   Molecular Oncology

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Angiogenesis inhibitors as therapeutic agents in cancer: Challenges and future directions

(2016) Zhexuan Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer

(2015) Zhe-Wei Wei et al.   CANCER LETTERS

Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth

(2015) G. Gritsina et al.   MOLECULAR CANCER THERAPEUTICS

Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment

(2015) Wei Pan et al.   TUMOR BIOLOGY

Anterior gradient protein 2 expression in high grade head and neck squamous cell carcinoma correlated with cancer stem cell and epithelial mesenchymal transition

(2015) Si-Rui Ma et al.   Oncotarget

Protein Kinase CK2 and Angiogenesis

(2015) Mathias Montenarh   Advances in Clinical and Experimental Medicine

Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells

(2015) Hua Xiong et al.   NEOPLASIA

Involvement of Nuclear JAK2 Signaling in AG490-Induced Apoptosis of Gastric Cancer Cells

(2014) Cuijuan Qian et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells

(2014) RENG-YUN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway

(2014) YOUN HEE JOUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

(2013) Lu Zhang et al.   CANCER LETTERS

Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

(2013) P. Cheng et al.   CANCER RESEARCH

IL-17A Stimulates the Progression of Giant Cell Tumors of Bone

(2013) M. Xu et al.   CLINICAL CANCER RESEARCH

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

(2013) David Vasquez-Dunddel et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of the Signal Transducers and Activators of Transcription (STAT) 3 Signalling Pathway by AG490 in Laryngeal Carcinoma Cells

(2013) H Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

A Potent Anti-Carcinoma and Anti-Acute Myeloblastic Leukemia Agent, AG490

(2012) Julio Caceres-Cortes   Anti-Cancer Agents in Medicinal Chemistry

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway

(2012) Guanglei Zhuang et al.   EMBO JOURNAL

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer

(2011) Mei Zhao et al.   LUNG CANCER

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro

(2010) Chen Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Decrease of Regulatory T Cells Correlates With Overall Survival After Sunitinib-based Antiangiogenic Therapy in Metastatic Renal Cancer Patients

(2010) Olivier Adotevi et al.   JOURNAL OF IMMUNOTHERAPY

HPV-associated head and neck cancer: a virus-related cancer epidemic

(2010) Shanthi Marur et al.   LANCET ONCOLOGY

Curcumin Dually Inhibits Both Mammalian Target of Rapamycin and Nuclear Factor- B Pathways through a Crossed Phosphatidylinositol 3-Kinase/Akt/I B Kinase Complex Signaling Axis in Adenoid Cystic Carcinoma

(2010) Z.-J. Sun et al.   MOLECULAR PHARMACOLOGY

Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2

(2009) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

(2008) Takuya Osada et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sunitinib Reverses Type-1 Immune Suppression and Decreases T-Regulatory Cells in Renal Cell Carcinoma Patients

(2008) J. H. Finke et al.   CLINICAL CANCER RESEARCH

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION

Head and neck cancer

(2008) Athanassios Argiris et al.   LANCET