Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder

Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

(2022) Rishabh Khera et al.   MOLECULES

Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage

(2022) Kuldeep Singh Jadaun et al.   Current Medical Science

Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain

(2021) Nitish Kumar et al.   METABOLIC BRAIN DISEASE

Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats

(2021) Aarti Tiwari et al.   Brain Sciences

Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

(2021) S Rahi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases

(2021) Anshuman Singh et al.   NEUROTOXICITY RESEARCH

Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit

(2020) Jingchuan Wu et al.   Translational Stroke Research

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

(2020) Dexiang Liu et al.   Frontiers in Pharmacology

The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats

(2020) Mahdi Abounoori et al.   NEUROTOXICITY RESEARCH

Suppression of cortico-striatal circuit activity improves cognitive flexibility and prevents body weight loss in activity-based anorexia in rats

(2020) Laura K. Milton et al.   BIOLOGICAL PSYCHIATRY

Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health

(2020) Sen Yin et al.   NEURAL PLASTICITY

Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors

(2020) Yun-Fang Jia et al.   BEHAVIOURAL BRAIN RESEARCH

Multi-level assessment of obsessive-compulsive disorder (OCD) reveals relations between neural and neurochemical levels

(2020) Kathrin Viol et al.   BMC Psychiatry

Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals

(2020) Saloni Rahi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive–compulsive disorder

(2020) Minah Kim et al.   Scientific Reports

Neuroprotective Potential of Adenyl Cyclase/cAMP/CREB and Mitochondrial CoQ10 Activator in Amyotrophic Lateral Sclerosis Rats

(2020) Mohmmad Mamtaj Alam et al.   Current Bioactive Compounds

Clobetasol Modulates Adult Neural Stem Cell Growth via Canonical Hedgehog Pathway Activation

(2019) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective effects of a Smoothened receptor agonist against postoperative cognitive dysfunction by promoting autophagy in the dentate gyrus of aged rats

(2019) Pei-Jun Li et al.   NEUROLOGICAL RESEARCH

Functional connectivity of the raphe nucleus as a predictor of the response to selective serotonin reuptake inhibitors in obsessive-compulsive disorder

(2019) Minah Kim et al.   NEUROPSYCHOPHARMACOLOGY

Obsessive–compulsive disorder

(2019) Dan J. Stein et al.   Nature Reviews Disease Primers

Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation

(2019) Mona Gerentes et al.   Current Psychiatry Reports

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

(2019) Zhiyong Xiong et al.   Aging-US

Parental morphine exposure affects repetitive grooming actions and marble burying behavior in the offspring: Potential relevance for obsessive-compulsive like behavior

(2019) Kiyana Rohbani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of glutamate-related drugs on anxiety and compulsive behavior in rats with obsessive-compulsive disorder

(2019) Yuhua Zhan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neurobiology and consequences of social isolation stress in animal model—A comprehensive review

(2018) Faiza Mumtaz et al.   BIOMEDICINE & PHARMACOTHERAPY

Sonic hedgehog in vertebrate neural tube development

(2018) Marysia Placzek et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats

(2018) Sunaina Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline

(2018) Jennifer I. Lissemore et al.   Translational Psychiatry

Sertraline Effects on Striatal Resting-State Functional Connectivity in Youth With OCD: A Pilot Study

(2018) Gail A. Bernstein et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Blood levels of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha and cognitive functions in patients with obsessive compulsive disorder

(2018) Evrim Özkorumak Karagüzel et al.   COMPREHENSIVE PSYCHIATRY

Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway

(2017) Shuai Shao et al.   Molecular Medicine Reports

Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy

(2016) Shengjie Feng et al.   EMBO REPORTS

Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats

(2016) Shamsher Singh et al.   PHARMACOLOGY

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

(2016) Borwin Bandelow et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Functional connectivity of the dorsal and median raphe nuclei at rest

(2015) Vincent Beliveau et al.   NEUROIMAGE

Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour

(2015) Claire Y. Savy et al.   NEUROTOXICOLOGY

Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders

(2015) Melissa Furtado et al.   PSYCHIATRY RESEARCH

Experimental evidence for the potential of lycopene in the management of scopolamine induced amnesia

(2015) Rajni Bala et al.   RSC Advances

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

(2015) Koral Goltseker et al.   Jove-Journal of Visualized Experiments

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

(2014) Waseem Hassan et al.   Current Neuropharmacology

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury

(2014) O V Chechneva et al.   Cell Death & Disease

Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and creb pathway

(2013) Tushar Arora et al.   BEHAVIOURAL BRAIN RESEARCH

Oxidative stress and therapeutic implications in psychiatric disorders

(2013) Xiang Yang Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit

(2012) Ahmad H. Alkhatib et al.   BEHAVIOURAL PHARMACOLOGY

Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion

(2011) Lijuan Song et al.   CELL RESEARCH

Effect of Aripiprazole Augmentation of Serotonin Reuptake Inhibitors or Clomipramine in Treatment-Resistant Obsessive-Compulsive Disorder

(2011) Maria Rosaria A. Muscatello et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Sonic Hedgehog is Cytoprotective against Oxidative Challenge in a Cellular Model of Amyotrophic Lateral Sclerosis

(2011) Randy Peterson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Malondialdehyde, Bcl-2, Superoxide Dismutase and Glutathione Peroxidase may Mediate the Association of Sonic Hedgehog Protein and Oxidative Stress in Autism

(2011) Ahmad Ghanizadeh   NEUROCHEMICAL RESEARCH

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

(2011) Christopher Pittenger et al.   PHARMACOLOGY & THERAPEUTICS

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex

(2010) Anna Dvorkin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of dopamine in the pathophysiology and treatment of obsessive–compulsive disorder

(2010) Min-Seong Koo et al.   Expert Review of Neurotherapeutics

Adaptation to potential threat: The evolution, neurobiology, and psychopathology of the security motivation system

(2010) Erik Z. Woody et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of NMDA receptors in the signal attenuation rat model of obsessive–compulsive disorder

(2010) Noa Albelda et al.   PSYCHOPHARMACOLOGY

High-dose selective serotonin reuptake inhibitors in OCD: a systematic retrospective case notes survey

(2009) I. Pampaloni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Small-molecule modulators of the Sonic Hedgehog signaling pathway

(2009) Benjamin Z. Stanton et al.   Molecular BioSystems

Role of nitric oxide in obsessive–compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice

(2009) S.N. Umathe et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication

(2008) A M Ruscio et al.   MOLECULAR PSYCHIATRY