Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway

(2021) Ruxi Lv et al.   TheScientificWorldJOURNAL

Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain

(2021) Nitish Kumar et al.   METABOLIC BRAIN DISEASE

Connection between JAK/STAT and PPARγ signaling during the progression of multiple sclerosis: Insights into the modulation of T-cells and immune responses in the brain

(2021) Nitish Kumar et al.   Current Molecular Pharmacology

Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats

(2021) Aarti Tiwari et al.   Brain Sciences

Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD

(2021) Jennifer R. Mepham et al.   BEHAVIOURAL BRAIN RESEARCH

Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors

(2021) Dingding Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

(2021) S Rahi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS

(2021) Elizabeth Minj et al.   NEUROCHEMICAL RESEARCH

Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis

(2021) Julio Vaquerizo-Serrano et al.   JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS

Parental Views of Families of Children with Autism Spectrum Disorder and Developmental Disorders During the COVID-19 Pandemic

(2021) Bekir Fatih Meral   JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS

Neuronal and glial cell number is altered in a cortical layer-specific manner in autism

(2021) Carmen Falcone et al.   AUTISM

Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice

(2020) Atsuki Kawamura et al.   HUMAN MOLECULAR GENETICS

Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats

(2020) Raju Paudel et al.   NEUROTOXICITY RESEARCH

Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

(2020) Bas Castelijns et al.   Nature Communications

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

(2020) Moonseok Choi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential

(2020) Masahito Morimoto et al.   PLoS One

Possible Involvement of the IL-6/JAK2/STAT3 Pathway in the Hypothalamus in Depressive-Like Behavior of Rats Exposed to Chronic Mild Stress

(2020) Xiaofeng Guan et al.   NEUROPSYCHOBIOLOGY

Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder

(2020) Dionisio A. Amodeo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Protective Effects of Peroxisome Proliferator-Activated Receptor Gamma in Cerebral Ischemia-Reperfusion Injury

(2020) Yanping Ding et al.   Frontiers in Neurology

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

(2019) Gabriella E. DiCarlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain’s major ion channels and neurotransmitter receptors

(2019) Kathryn M. Hixson et al.   BMC GENOMICS

A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress

(2019) Roohi Mirza et al.   CHEMICO-BIOLOGICAL INTERACTIONS

T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains

(2019) Marcello M. DiStasio et al.   ANNALS OF NEUROLOGY

The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T+ Itpr3tf/J mouse model of autism

(2019) Sheikh F. Ahmad et al.   BRAIN RESEARCH BULLETIN

Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

(2019) P. M. Abruzzo et al.   Journal of Translational Medicine

Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder

(2018) Daoyin Dong et al.   Autism Research

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases

(2018) Zhaoqi Yan et al.   CLINICAL IMMUNOLOGY

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

(2018) Piotr Czarny et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids

(2018) Michael Heming et al.   Frontiers in Immunology

S3I-201, a selective Stat3 inhibitor, restores neuroimmune function through upregulation of Treg signaling in autistic BTBR T+ Itpr3tf/J mice

(2018) Sheikh F. Ahmad et al.   CELLULAR SIGNALLING

Tanshinone modulates the expression of Bcl-2 and Bax in cardiomyocytes and has a protective effect in a rat model of myocardial ischemia-reperfusion

(2018) Rui Guo et al.   Hellenic Journal of Cardiology

PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway

(2018) Alexandre Vallée et al.   MOLECULAR PSYCHIATRY

Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats

(2018) Roohi Mirza et al.   LIFE SCIENCES

Docosahexaenoic acid inhibits IL-6 expression via PPARγ-mediated expression of catalase in cerulein-stimulated pancreatic acinar cells

(2017) Eun Ah Song et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway

(2017) Feng-Guo Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neonatal and regressive forms of autism: Diseases with similar symptoms but a different etiology

(2017) William E. Barbeau   MEDICAL HYPOTHESES

Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers

(2017) Asma M. Khemakhem et al.   METABOLIC BRAIN DISEASE

Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders

(2017) Sidharth Mehan et al.   Neural Regeneration Research

Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders

(2017) Ranjana Bhandari et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis

(2017) Silvia Rossi et al.   NEUROLOGY

The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

(2017) Katharine Victoria Jensen et al.   PLoS One

Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

(2017) Selin Aktan Guloksuz et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Expression of caspase-3, Bax and Bcl-2 in hippocampus of rats with diabetes and subarachnoid hemorrhage

(2017) Xin He et al.   Experimental and Therapeutic Medicine

The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research

(2017) Rebecca Wafer et al.   Frontiers in Endocrinology

Activation of the JAK-STAT Signaling Pathway after In Vitro Stimulation with IFNß in Multiple Sclerosis Patients According to the Therapeutic Response to IFNß

(2017) Isaac Hurtado-Guerrero et al.   PLoS One

PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

(2016) Juan Carlos Corona et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

(2016) Hongwei Qin et al.   JOURNAL OF NEUROSCIENCE

Z-Guggulsterone Improves the Scopolamine-Induced Memory Impairments Through Enhancement of the BDNF Signal in C57BL/6J Mice

(2016) Zhuo Chen et al.   NEUROCHEMICAL RESEARCH

Altered neurotransmitter metabolism in adolescents with high-functioning autism

(2016) Gerhard S. Drenthen et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

(2016) Kui Shen et al.   ACS Catalysis

Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway

(2016) Jin-Hua Zhang et al.   Drug Design Development and Therapy

Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes

(2016) Emilia Heimann et al.   Adipocyte

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats

(2015) A.A. Martinez et al.   NEUROBIOLOGY OF DISEASE

Apitoxin protects rat pups brain from propionic acid-induced oxidative stress: The expression pattern of Bcl-2 and Caspase-3 apoptotic genes

(2015) Samah R. Khalil et al.   NEUROTOXICOLOGY

Excitatory/inhibitory imbalance in autism spectrum disorders: Implications for interventions and therapeutics

(2015) Genoveva Uzunova et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Experimental evidence for the potential of lycopene in the management of scopolamine induced amnesia

(2015) Rajni Bala et al.   RSC Advances

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior

(2015) Eryan Kong et al.   Scientific Reports

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis

(2014) Etty N. Benveniste et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

PPAR  Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

(2014) J. B. Jahrling et al.   JOURNAL OF NEUROSCIENCE

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

(2014) Bistra B. Nankova et al.   PLoS One

PPARγ activation inhibits cerebral arteriogenesis in the hypoperfused rat brain

(2013) A. Duelsner et al.   Acta Physiologica

Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism

(2013) Golan Karvat et al.   NEUROPSYCHOPHARMACOLOGY

Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism

(2012) Sarah Jacot-Descombes et al.   ACTA NEUROPATHOLOGICA

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

(2012) Pablo Garrido-Gil et al.   Journal of Neuroinflammation

Pharmacological Properties of Guggulsterones, the Major Active Components of Gum Guggul

(2012) Rohan Shah et al.   PHYTOTHERAPY RESEARCH

Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism

(2012) Michael J. Kane et al.   PLoS One

Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila

(2011) T. Copf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes

(2010) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor

(2009) Rahul Deshmukh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism

(2009) Ellisa Parker-Athill et al.   JOURNAL OF NEUROIMMUNOLOGY

Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) K. S. Ahn et al.   CANCER RESEARCH

Identification of a novel agonist of peroxisome proliferator-activated receptors α and γ that may contribute to the anti-diabetic activity of guggulipid in Lepob/Lepob mice

(2008) Claire L. Cornick et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

15-Deoxy- 12,14-prostaglandin J2 inhibits INF- -induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells

(2008) U. Panzer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Altered cerebellar feedback projections in Asperger syndrome

(2008) Marco Catani et al.   NEUROIMAGE

SOCS 3 and PPAR-γ ligands inhibit the expression of IL-6 and TGF-β1 by regulating JAK2/STAT3 signaling in pancreas

(2007) Ji Hoon Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY