Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage

Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain

(2021) Nitish Kumar et al.   METABOLIC BRAIN DISEASE

Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats

(2021) Aarti Tiwari et al.   Brain Sciences

Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism

(2021) S Rahi et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS

(2021) Elizabeth Minj et al.   NEUROCHEMICAL RESEARCH

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

(2021) Aarti Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage

(2021) Ehraz Mehmood Siddiqui et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Acute Stress Induces Cognitive Improvement in the Novel Object Recognition Task by Transiently Modulating Bdnf in the Prefrontal Cortex of Male Rats

(2020) Paola Brivio et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Echinocystic acid provides a neuroprotective effect via the PI3K/AKT pathway in intracerebral haemorrhage mice

(2020) Beilei Chen et al.   Annals of Translational Medicine

The pharmacological properties of chrysophanol, the recent advances

(2020) Siyu Su et al.   BIOMEDICINE & PHARMACOTHERAPY

Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats

(2020) Tao Wang et al.   METABOLIC BRAIN DISEASE

Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

(2020) Hong-Bin Wang et al.   ACS Omega

Investigation of low dose cabazitaxel potential as microtubule stabilizer in experimental model of Alzheimer's disease: Restoring neuronal cytoskeleton

(2020) Pallavi Duggal et al.   Current Alzheimer Research

Neuroprotective Potential of Adenyl Cyclase/cAMP/CREB and Mitochondrial CoQ10 Activator in Amyotrophic Lateral Sclerosis Rats

(2020) Mohmmad Mamtaj Alam et al.   Current Bioactive Compounds

The peacefulness gene promotes aggression in Drosophila

(2019) Mahmoudreza Ramin et al.   Molecular Brain

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

CD47 Blocking Antibody Accelerates Hematoma Clearance After Intracerebral Hemorrhage in Aged Rats

(2019) Chuanyuan Tao et al.   Translational Stroke Research

Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway

(2019) Hua-bin Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice

(2019) Mingxi Li et al.   Translational Research

Chrysophanol demonstrates anti-inflammatory properties in LPS-primed RAW 264.7 macrophages through activating PPAR-γ

(2018) Quan Wen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models

(2018) Hyun-Ja Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective effects of Quercetin on radiation-induced brain injury in rats

(2018) Aydemir Kale et al.   JOURNAL OF RADIATION RESEARCH

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

(2018) Paul M Daniel et al.   NEURO-ONCOLOGY

Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice

(2018) Xu Chu et al.   NEUROCHEMICAL RESEARCH

Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis

(2018) Santa Mammana et al.   Oncotarget

Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion

(2018) Yongmei Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways

(2018) Sunwoo Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage

(2018) Yinan Wu et al.   Frontiers in Psychiatry

Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis

(2017) Sabrina Giacoppo et al.   FITOTERAPIA

Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats

(2017) Hengli Zhao et al.   Journal of Neuroinflammation

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders

(2017) Sidharth Mehan et al.   Neural Regeneration Research

Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage

(2017) Jing Chen-Roetling et al.   NEUROBIOLOGY OF DISEASE

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

(2017) Navdeep Singh et al.   PHARMACOLOGY

Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission

(2017) Unbin Chae et al.   PHARMACOLOGY

Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective role of free and quercetin-loaded nanoemulsion against damage induced by intracerebral haemorrhage in rats

(2016) A R Galho et al.   NANOTECHNOLOGY

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

(2016) Sumit Jamwal et al.   PHYSIOLOGY & BEHAVIOR

Physiopathologie du choc hémorragique

(2016) R. Copotoiu et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Protective effect of chrysophanol on LPS/d-GalN-induced hepatic injury through the RIP140/NF-κB pathway

(2016) Wenjiao Jiang et al.   RSC Advances

Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons

(2015) Zhaohua Xiao et al.   JOURNAL OF NEUROIMMUNOLOGY

Experimental intracerebral haemorrhage: description of a semi-coagulated autologous blood model in rats

(2015) Liang Liu et al.   NEUROLOGICAL RESEARCH

Experimental evidence for the potential of lycopene in the management of scopolamine induced amnesia

(2015) Rajni Bala et al.   RSC Advances

The Pathophysiology of Intracerebral Hemorrhage Formation and Expansion

(2015) Frieder Schlunk et al.   Translational Stroke Research

Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury

(2014) Yongliang Zhang et al.   Neural Regeneration Research

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway

(2013) AI CHEN et al.   Molecular Medicine Reports

Chrysophanol–phospholipid complex

(2012) Devendra Singh et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase

(2012) Paul R. Krafft et al.   Jove-Journal of Visualized Experiments

Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines

(2011) Weiguang Zhang et al.   EXPERIMENTAL NEUROLOGY

Phosphatidylinositol 3-Kinase Facilitates Microtubule-dependent Membrane Transport for Neuronal Growth Cone Guidance

(2010) Hiroki Akiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

(2010) Charlotte JJ van Asch et al.   LANCET NEUROLOGY

Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells

(2010) Chi-Cheng Lu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

COMPARISON OF EXPERIMENTAL RAT MODELS OF EARLY BRAIN INJURY AFTER SUBARACHNOID HEMORRHAGE

(2009) Jin-Yul Lee et al.   NEUROSURGERY

A mouse model of intracerebral hemorrhage using autologous blood infusion

(2008) Michal A Rynkowski et al.   Nature Protocols

Cerebral Amyloid Angiopathy: Progressive Disruption of the Neurovascular Unit

(2008) G. J. Zipfel et al.   STROKE