The Emerging Role of Macrophages in Chronic Obstructive Pulmonary Disease: The Potential Impact of Oxidative Stress and Extracellular Vesicle on Macrophage Polarization and Function

Extracellular Vesicles from Airway Secretions: New Insights in Lung Diseases

(2021) Laura Pastor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Potential Roles of Exosomes in Chronic Obstructive Pulmonary Disease

(2021) Nan Wang et al.   Frontiers in Medicine

Role of extracellular vesicles in chronic lung disease

(2021) Anne Trappe et al.   THORAX

Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures

(2021) Hiroto Takiguchi et al.   Scientific Reports

The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases

(2021) Jae-Won Lee et al.   Cells

Oxidative Stress Biomarkers in Chronic Obstructive Pulmonary Disease Exacerbations: A Systematic Review

(2021) Elisabetta Zinellu et al.   Antioxidants

Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease

(2021) Lijing Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The inhibitor miR-21 regulates macrophage polarization in an experimental model of chronic obstructive pulmonary disease

(2021) JunJuan Lu et al.   Tobacco Induced Diseases

Extracellular Vesicles as Central Mediators of COPD Pathophysiology

(2021) Derek W. Russell et al.   Annual Review of Physiology

miRNAomics analysis reveals the promoting effects of cigarette smoke extract-treated Beas-2B-derived exosomes on macrophage polarization

(2021) Zhen Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered polarization and impaired phagocytic activity of lung macrophages in people with HIV and COPD

(2021) Kentaro Akata et al.   JOURNAL OF INFECTIOUS DISEASES

Focus on Early COPD: Definition and Early Lung Development

(2021) Weichang Yang et al.   International Journal of Chronic Obstructive Pulmonary Disease

From Biomarkers to Novel Therapeutic Approaches in Chronic Obstructive Pulmonary Disease

(2021) Hsu-Hui Wang et al.   Biomedicines

MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia

(2021) Ye Li et al.   Cell Death Discovery

Effect of Antioxidants in the Treatment of COPD Patients: Scoping Review

(2021) Mauricio Orozco-Levi et al.   Journal of Nutrition and Metabolism

Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease

(2020) Kentaro Akata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury

(2020) Lu Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

(2020) Tine Tesovnik et al.   Frontiers in Cell and Developmental Biology

Oxidative stress-based therapeutics in COPD

(2020) Peter J. Barnes   Redox Biology

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

(2020) Mauro Finicelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages

(2020) Yanqing Le et al.   Frontiers in Immunology

Microvesicles in bronchoalveolar lavage as a potential biomarker of COPD

(2020) Erica Bazzan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Microenvironmental stimuli induce different macrophage polarizations in experimental models of emphysema

(2019) Júlia Benini Kohler et al.   Biology Open

Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling

(2019) Pieter S. Hiemstra   EBioMedicine

Bronchial epithelial cell extracellular vesicles ameliorate epithelial–mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization

(2019) Shengyang He et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets

(2019) Julien Guiot et al.   Journal of Clinical Medicine

Extracellular vesicles in chronic obstructive pulmonary disease (COPD)

(2019) Hannah E. O’Farrell et al.   Journal of Thoracic Disease

An emerging interplay between extracellular vesicles and cytokines

(2019) Alessandra Aiello et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The key role of macrophage depolarization in the treatment of COPD with ergosterol both in vitro and in vivo

(2019) Xiao Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular techniques for respiratory diseases: MicroRNA and extracellular vesicles

(2019) Yasuhiro Gon et al.   RESPIROLOGY

Activation of M1 macrophages plays a critical role in the initiation of acute lung injury

(2018) Hui-Lun Lu et al.   BIOSCIENCE REPORTS

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD

(2018) Kei Yamasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The potential theragnostic (diagnostic+therapeutic) application of exosomes in diverse biomedical fields

(2018) Yong-Seok Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macrophage polarization and allergic asthma

(2018) Arjun Saradna et al.   Translational Research

Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury

(2018) Heedoo Lee et al.   Frontiers in Immunology

Oxidative stress and macrophages: driving forces behind exacerbations of asthma and COPD?

(2018) Linsey Elisabeth Susan de Groot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy

(2018) Xiaoliang Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation

(2017) Dino B.A. Tan et al.   RESPIRATORY MEDICINE

Macrophage phagocytosis cracking the defect code in COPD

(2017) Jamil Jubrail et al.   Biomedical Journal

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

(2017) Mathew Suji Eapen et al.   Scientific Reports

Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation

(2016) Patricia Carrasco-Ramírez et al.   Oncotarget

Structural and functional characterization of endothelial microparticles released by cigarette smoke

(2016) Karina A. Serban et al.   Scientific Reports

Impaired Innate COPD Alveolar Macrophage Responses and Toll-Like Receptor-9 Polymorphisms

(2015) Charles S. Berenson et al.   PLoS One

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Extracellular vesicles in lung microenvironment and pathogenesis

(2015) Yu Fujita et al.   TRENDS IN MOLECULAR MEDICINE

Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs

(2015) Rinat Zaynagetdinov et al.   Oncotarget

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

(2015) Sanyukta Rana et al.   NEOPLASIA

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes

(2014) Ugur Gezer et al.   CELL BIOLOGY INTERNATIONAL

Rapid shedding of proinflammatory microparticles by human mononuclear cells exposed to cigarette smoke is dependent on Ca2+ mobilization

(2014) Cinzia Cordazzo et al.   INFLAMMATION RESEARCH

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Oxidative Stress Decreases Functional Airway Mannose Binding Lectin in COPD

(2014) Hai B. Tran et al.   PLoS One

Exosomes - Structure, Biogenesis and Biological Role in Non-Small-Cell Lung Cancer

(2014) M. Frydrychowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Role of alveolar macrophages in chronic obstructive pulmonary disease

(2014) Ross Vlahos   Frontiers in Immunology

Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke

(2013) Chun-Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease

(2013) Charles S. Berenson et al.   JOURNAL OF INFECTIOUS DISEASES

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Macrophage Heterogeneity in Respiratory Diseases

(2013) Carian E. Boorsma et al.   MEDIATORS OF INFLAMMATION

Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

(2013) Jill C Todt et al.   RESPIRATORY RESEARCH

Classically Activated Macrophages Use Stable Microtubules for Matrix Metalloproteinase-9 (MMP-9) Secretion

(2012) Raed Hanania et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

(2011) G. Caramori et al.   THORAX

Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages

(2010) Mingzhen Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages

(2010) Qingshan Wang et al.   CELL RESEARCH

Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release

(2010) Elena Sierra-Filardi et al.   IMMUNOBIOLOGY

DNA damage and repair in a model of rat vascular injury

(2009) Amalia Forte et al.   CLINICAL SCIENCE

Nontypeable Haemophilus influenzae Clearance by Alveolar Macrophages Is Impaired by Exposure to Cigarette Smoke

(2009) P. Marti-Lliteras et al.   INFECTION AND IMMUNITY

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Azithromycin Improves Macrophage Phagocytic Function and Expression of Mannose Receptor in Chronic Obstructive Pulmonary Disease

(2008) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke

(2008) C Le Quément et al.   BRITISH JOURNAL OF PHARMACOLOGY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

(2008) Michael R. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

Exosome Function: From Tumor Immunology to Pathogen Biology

(2008) Jeffrey S. Schorey et al.   TRAFFIC

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL