Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets

Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses

(2019) Heather H. Pua et al.   Cell Reports

Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation

(2019) Megan R. Showalter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model

(2019) Meng-Ying Yao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bronchial epithelial cell extracellular vesicles ameliorate epithelial–mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization

(2019) Shengyang He et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma

(2018) Yu-mo Du et al.   EXPERIMENTAL CELL RESEARCH

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

(2018) Mahesh Khatri et al.   Stem Cell Research & Therapy

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

(2018) Byong Seung Cho et al.   Stem Cell Research & Therapy

Intercellular Communication between Airway Epithelial Cells is Mediated by Exosome-Like Vesicles

(2018) Richa Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis

(2018) Makon-Sébastien Njock et al.   THORAX

Idiopathic Pulmonary Fibrosis (IPF): An Overview

(2018) Shaney Barratt et al.   Journal of Clinical Medicine

Identification of miRNA-rich vesicles in bronchoalveolar lavage fluid: Insights into the function and heterogeneity of extracellular vesicles

(2018) Heedoo Lee et al.   JOURNAL OF CONTROLLED RELEASE

A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD

(2018) Peilong Lai et al.   Journal of Hematology & Oncology

Lung Epithelial Cell–Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221–Induced Integrin β1Recycling

(2017) Heedoo Lee et al.   JOURNAL OF IMMUNOLOGY

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222

(2017) Ziwen Zhu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blood Biomarkers in Idiopathic Pulmonary Fibrosis

(2017) Julien Guiot et al.   LUNG

Clinical experience in idiopathic pulmonary fibrosis: a retrospective study

(2017) Julien Guiot et al.   ACTA CLINICA BELGICA

Methodology for Sputum Induction and Laboratory Processing

(2017) Julien Guiot et al.   Jove-Journal of Visualized Experiments

Sputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7

(2017) J. Guiot et al.   PLoS One

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

(2016) Farrukh Aqil et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production

(2016) Heather H. Pua et al.   IMMUNITY

Asthma inflammatory phenotypes show differential microRNA expression in sputum

(2016) Tania Maes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs

(2016) Heedoo Lee et al.   Scientific Reports

Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis

(2016) J. Guiot et al.   BMC Pulmonary Medicine

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Structural and functional characterization of endothelial microparticles released by cigarette smoke

(2016) Karina A. Serban et al.   Scientific Reports

Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice

(2015) Antoine Monsel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

(2015) M.-S. Njock et al.   BLOOD

Global and regional trends in COPD mortality, 1990–2010

(2015) Peter G.J. Burney et al.   EUROPEAN RESPIRATORY JOURNAL

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

(2015) Emilie Bourdonnay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway

(2015) H-G Moon et al.   Cell Death & Disease

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

(2015) Nicolas Bovy et al.   Oncotarget

Advances and Challenges of Liposome Assisted Drug Delivery

(2015) Lisa Sercombe et al.   Frontiers in Pharmacology

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Is nanotechnology a boon for oral drug delivery?

(2014) Udita Agrawal et al.   DRUG DISCOVERY TODAY

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

(2014) M Aga et al.   ONCOGENE

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery

(2013) Koen Raemdonck et al.   CHEMICAL SOCIETY REVIEWS

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

(2013) Bettina Levänen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice

(2013) Ying-gang Zhu et al.   STEM CELLS

Increased skeletal muscle-specific microRNA in the blood of patients with COPD

(2013) Anna Donaldson et al.   THORAX

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

(2012) Laura K. Johnston et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?

(2012) Matthew D Griffin et al.   IMMUNOLOGY AND CELL BIOLOGY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

The Role of Alveolar Epithelial Cells in Initiating and Shaping Pulmonary Immune Responses: Communication between Innate and Adaptive Immune Systems

(2012) Olga D. Chuquimia et al.   PLoS One

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-  Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

(2011) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

(2010) Renat Shaykhiev et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis

(2010) Aurélie Leroyer et al.   THROMBOSIS AND HAEMOSTASIS

TRAIL/Apo2L Mediates the Release of Procoagulant Endothelial Microparticles Induced by Thrombin In Vitro

(2009) Stéphanie Simoncini et al.   CIRCULATION RESEARCH

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

(2009) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE