Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Targeting adenosine and regulatory T cells in cancer immunotherapy

(2021) Alexey Churov et al.   HUMAN IMMUNOLOGY

Targeting adenosine with adenosine deaminase 2 to inhibit growth of solid tumors

(2021) Lin Wang et al.   CANCER RESEARCH

Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer

(2021) Barbara Kutryb-Zajac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adenosine Deaminase 1 Overexpression Enhances the Antitumor Efficacy of Chimeric Antigen Receptor-Engineered T Cells

(2021) Yun Qu et al.   HUMAN GENE THERAPY

Adenosine kinase: An epigenetic modulator in development and disease

(2021) Madhuvika Murugan et al.   NEUROCHEMISTRY INTERNATIONAL

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

(2021) Oludare A. Odumade et al.   Frontiers in Immunology

Diagnostic value of adenosine deaminase in bronchoalveolar lavage fluid for patients with lung cancer

(2021) İclal Hocanlı et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Regulation of immune responses through CD39 and CD73 in cancer: Novel checkpoints

(2021) Elham Baghbani et al.   LIFE SCIENCES

Cancer biology and molecular genetics of A3 adenosine receptor

(2021) Chiara Mazziotta et al.   ONCOGENE

Targeting regulatory T cells in anti‐PD‐1/PD‐L1 cancer immunotherapy

(2021) Galina Zhulai et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

(2021) Eveline M. Delemarre et al.   Frontiers in Immunology

Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation

(2020) Yong Wang et al.   CARDIOVASCULAR RESEARCH

CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

(2020) Miao Yu et al.   Nature Communications

Dysregulation of adenosine kinase isoforms in breast cancer

(2020) Bahar Shamloo et al.   Oncotarget

Control of Metastases via Myeloid CD39 and NK Cell Effector Function

(2020) Juming Yan et al.   Cancer Immunology Research

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia

(2020) Karolina Losenkova et al.   JOURNAL OF CELL SCIENCE

The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth

(2020) Siqi Chen et al.   Cancer Immunology Research

Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade

(2020) Rui Yang et al.   Journal for ImmunoTherapy of Cancer

Adenosine deaminase 2 activity negatively correlates with age during childhood

(2020) Sarah M. Bowers et al.   Pediatric Rheumatology

Adenosine kinase: A key regulator of purinergic physiology

(2020) Detlev Boison et al.   BIOCHEMICAL PHARMACOLOGY

Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE −/− (Apolipoprotein E Deficient) Mice

(2019) Min Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV

(2019) Virginie Tardif et al.   Nature Communications

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

(2019) Helai P. Mohammad et al.   NATURE MEDICINE

Deletion of pancreatic β‐cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin‐induced hyperglycaemia

(2019) Makawi Ahmed Abdalhamid Osman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hairy cell leukemia: present and future directions

(2019) Robert J. Kreitman   LEUKEMIA & LYMPHOMA

Adenosine deaminase inhibition

(2019) S. Bagheri et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ADA activity is decreased in lymphocytes from patients with advanced stage of lung cancer

(2019) Daniela Zanini et al.   MEDICAL ONCOLOGY

The diverse roles of DNA methylation in mammalian development and disease

(2019) Maxim V. C. Greenberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NT5E/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma

(2019) Jiao Wang et al.   Journal of Clinical Medicine

Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells

(2019) Farnaz Hajizadeh et al.   LIFE SCIENCES

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

(2018) Robert D. Leone et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adenosine signaling and the immune system: When a lot could be too much

(2018) Luca Antonioli et al.   IMMUNOLOGY LETTERS

Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, Genetics, Pathogenesis, and Treatment

(2018) Isabelle Meyts et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins

(2018) Estefanía Moreno et al.   Frontiers in Pharmacology

Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence

(2018) M.-N. Theodoraki et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The role of adenosine in epilepsy

(2018) Landen Weltha et al.   BRAIN RESEARCH BULLETIN

Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer

(2018) Maarit K Koivisto et al.   CARCINOGENESIS

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms

(2018) Barbara Kutryb-Zajac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

(2017) Paul A. Beavis et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

(2017) Si-Rui Ma et al.   Molecular Cancer

The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway

(2017) Yihong Zhou et al.   Oncotarget

Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455

(2017) Stefania Gessi et al.   Frontiers in Pharmacology

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

(2016) Arabella Young et al.   CANCER CELL

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis

(2016) D. Mittal et al.   CANCER RESEARCH

Human adenosine deaminases ADA1 and ADA2 bind to different subsets of immune cells

(2016) Yuliia Kaljas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep

(2016) Theresa E. Bjorness et al.   JOURNAL OF NEUROSCIENCE

Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection

(2016) Xiao-Yan Cai et al.   MEDICINE

Monogenic polyarteritis: the lesson of ADA2 deficiency

(2016) Roberta Caorsi et al.   Pediatric Rheumatology

Serum adenosine deaminase, catalase, and carbonic anhydrase activities in patients with renal cell carcinoma

(2016) Necip Pirinççi et al.   REDOX REPORT

Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation

(2016) Katharina Kiese et al.   Frontiers in Molecular Neuroscience

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

Adenosine Deaminase Inhibitor EHNA Exhibits a Potent Anticancer Effect Against Malignant Pleural Mesothelioma

(2015) Yasuhiro Nakajima et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options

(2015) Christian Staufner et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1

(2015) Isaac Naval-Macabuhay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma-associated epilepsy

(2015) JUN HUANG et al.   Molecular Medicine Reports

The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men

(2015) Amir Fattahi et al.   UROLOGY

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

(2015) Claudia Sorrentino et al.   Oncotarget

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

(2015) Fabio Morandi et al.   Oncotarget

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nucleoside transporters in the purinome

(2014) Alexandre dos Santos-Rodrigues et al.   NEUROCHEMISTRY INTERNATIONAL

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

(2014) Paulina Navon Elkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

(2014) M. V. Sitkovsky et al.   Cancer Immunology Research

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

(2013) Melanie Mediavilla-Varela et al.   CANCER BIOLOGY & THERAPY

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

(2013) Alberto L Horenstein et al.   OncoImmunology

Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis

(2012) Vanessa Battisti et al.   BIOMEDICINE & PHARMACOTHERAPY

Serum adenosine deaminase, catalase and carbonic anhydrase activities in patients with bladder cancer

(2012) N Pirinççi et al.   Clinics

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma

(2012) Magis Mandapathil et al.   OncoImmunology

Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function

(2011) Magnus K. Bjursell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Adenosine deaminase activity in fertile and infertile men

(2011) F. Rostampour et al.   ANDROLOGIA

Molecular Characterization of Chinese Hamster Cells Mutants Affected in Adenosine Kinase and Showing Novel Genetic and Biochemical Characteristics

(2011) Xianying A Cui et al.   BMC BIOCHEMISTRY

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Diagnostic Value of Adenosine Deaminase Activity in Benign and Malignant Breast Tumors

(2010) Mahmoud Aghaei et al.   ARCHIVES OF MEDICAL RESEARCH

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

(2010) Anton V. Zavialov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages

(2010) A. V. Zavialov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Manipulation of Adenosine Kinase Affects Sleep Regulation in Mice

(2010) S. Palchykova et al.   JOURNAL OF NEUROSCIENCE

Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus

(2009) Xianying Amy Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How I treat ADA deficiency

(2009) H. B. Gaspar et al.   BLOOD

Adenosine and Sleep

(2009) Theresa Bjorness et al.   Current Neuropharmacology

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Adenosine kinase and ribokinase – the RK family of proteins

(2008) J. Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia

(2008) Julio C. Morote–Garcia et al.   GASTROENTEROLOGY

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice

(2008) Tianfu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine Kinase Gene Expression in Human Colorectal Cancer

(2008) S. Giglioni et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS