The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function

Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets

(2022) Magdalena Prechova et al.   JOURNAL OF CELL BIOLOGY

Desmosomal Cadherins in Health and Disease

(2021) Marihan Hegazy et al.   Annual Review of Pathology-Mechanisms of Disease

Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

(2021) Joshua A. Broussard et al.   CURRENT BIOLOGY

Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

(2021) Lisa Müller et al.   Frontiers in Cell and Developmental Biology

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

(2021) Yin-Qiao Liu et al.   Biomolecules

A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex

(2021) Tong San Tan et al.   JOURNAL OF CELL SCIENCE

MiR-193b-3p–ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes

(2021) Cong Huang et al.   Cell Death & Disease

Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions

(2021) Arash Alizadeh et al.   Tissue Barriers

Plakophilin 3 phosphorylation by ribosomal S6 kinase supports desmosome assembly

(2020) Lisa Müller et al.   JOURNAL OF CELL SCIENCE

Tracing the Evolutionary Origin of Desmosomes

(2020) Kathleen J. Green et al.   CURRENT BIOLOGY

Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics

(2020) Florian Rouaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanics of a multilayer epithelium instruct tumour architecture and function

(2020) Vincent F. Fiore et al.   NATURE

Dsg1 deficiency causes lethal skin blistering

(2019) Daniela Kugelmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin–epidermal growth factor receptor signaling

(2019) Andrea Scheffschick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Desmosomes in Human Disease

(2018) Nicole A. Najor   Annual Review of Pathology-Mechanisms of Disease

The receptor tyrosine kinase ERBB4 is expressed in skin keratinocytes and influences epidermal proliferation

(2018) Christine Hoesl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Maintenance of tight junction barrier integrity in cell turnover and skin diseases

(2018) Mariko Yokouchi et al.   EXPERIMENTAL DERMATOLOGY

Epithelial barrier dysfunction in desmoglein-1 deficiency

(2018) Laura Polivka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

(2018) Volker Spindler et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

(2018) Oxana Nekrasova et al.   Nature Communications

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

(2017) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Cell–Cell Contact and Receptor Tyrosine Kinase Signaling

(2017) Christine Chiasson-MacKenzie et al.   Cold Spring Harbor Perspectives in Biology

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective

(2017) Matthias Rübsam et al.   Cold Spring Harbor Perspectives in Biology

Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics

(2017) Mechthild Hatzfeld et al.   Cold Spring Harbor Perspectives in Biology

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

(2017) Matthias Rübsam et al.   Nature Communications

Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex

(2017) Nicole Ann Najor et al.   eLife

E-cadherin-mediated force transduction signals regulate global cell mechanics

(2016) Ismaeel Muhamed et al.   JOURNAL OF CELL SCIENCE

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease

(2016) Jianchun Chen et al.   PHYSIOLOGICAL REVIEWS

Structural basis of adhesive binding by desmocollins and desmogleins

(2016) Oliver J. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin

(2015) Christine Chiasson-MacKenzie et al.   JOURNAL OF CELL BIOLOGY

Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover

(2015) Kristin Seltmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR

(2015) Su Yao et al.   JOURNAL OF PATHOLOGY

Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa

(2015) Giuseppina Annicchiarico et al.   MEDICINE

Desmoglein 3: A Help or a Hindrance in Cancer Progression?

(2015) Louise Brown et al.   Cancers

Role of Erbin in ErbB2-dependent breast tumor growth

(2014) Yanmei Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genomic and Cellular Foundations of Animal Origins

(2013) Daniel J. Richter et al.   Annual Review of Genetics

Actin filament dynamics impacts keratinocyte stem cell maintenance

(2013) Daisuke Nanba et al.   EMBO Molecular Medicine

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

(2013) Robert M. Harmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation

(2013) Daisuke Nanba et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Skin Fragility and Impaired Desmosomal Adhesion in Mice Lacking All Keratins

(2013) Janina Bär et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

(2013) Liat Samuelov et al.   NATURE GENETICS

Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy

(2013) F. Mascia et al.   Science Translational Medicine

Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation

(2013) B. M. Lichtenberger et al.   Science Translational Medicine

Contact inhibition (of proliferation) redux

(2012) Andrea I McClatchey et al.   CURRENT OPINION IN CELL BIOLOGY

An ErbB receptor-mediated AP-1 regulatory network is modulated by STAT3 and c-MYC during calcium-dependent keratinocyte differentiation

(2012) Yuko Saeki et al.   EXPERIMENTAL DERMATOLOGY

EGFR regulation of epidermal barrier function

(2012) Quynh T. Tran et al.   PHYSIOLOGICAL GENOMICS

Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/ -catenin complex

(2012) S. A. Nichols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

(2012) H. Suga et al.   Science Signaling

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

(2010) A. Moritz et al.   Science Signaling

Pervanadate stabilizes desmosomes

(2010) David R. Garrod et al.   Cell Adhesion & Migration

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth

(2009) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2

(2008) Jodi L. Klessner et al.   MOLECULAR BIOLOGY OF THE CELL

The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation

(2007) Saveria Pastore et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY