Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

Desmosomal Junctions Govern Tissue Integrity and Actomyosin Contractility in Apoptotic Cell Extrusion

(2020) Minnah Thomas et al.   CURRENT BIOLOGY

Scaling up single-cell mechanics to multicellular tissues – the role of the intermediate filament–desmosome network

(2020) Joshua A. Broussard et al.   JOURNAL OF CELL SCIENCE

Mechanics of a multilayer epithelium instruct tumour architecture and function

(2020) Vincent F. Fiore et al.   NATURE

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

(2019) Hendrik A. Messal et al.   NATURE

HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch

(2019) Nadir Yehya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling

(2019) Christopher R. Arnette et al.   Pigment Cell & Melanoma Research

The receptor tyrosine kinase ERBB4 is expressed in skin keratinocytes and influences epidermal proliferation

(2018) Christine Hoesl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

(2018) Oxana Nekrasova et al.   Nature Communications

Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation

(2018) Kailin R. Mesa et al.   Cell Stem Cell

A fluid-to-solid jamming transition underlies vertebrate body axis elongation

(2018) Alessandro Mongera et al.   NATURE

ERBB2 Is Essential for the Growth of Chemically Induced Skin Tumors in Mice

(2017) Maik Dahlhoff et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell–cell and cell–extracellular matrix adhesions cooperate to organize actomyosin networks and maintain force transmission during dorsal closure

(2017) Katharine Goodwin et al.   MOLECULAR BIOLOGY OF THE CELL

The desmoplakin–intermediate filament linkage regulates cell mechanics

(2017) Joshua A. Broussard et al.   MOLECULAR BIOLOGY OF THE CELL

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

(2017) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin

(2017) Amy E. Shyer et al.   SCIENCE

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective

(2017) Matthias Rübsam et al.   Cold Spring Harbor Perspectives in Biology

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

(2017) Matthias Rübsam et al.   Nature Communications

Epithelial Cell Packing Induces Distinct Modes of Cell Extrusions

(2016) Leyla Kocgozlu et al.   CURRENT BIOLOGY

Coronin 1B Reorganizes the Architecture of F-Actin Networks for Contractility at Steady-State and Apoptotic Adherens Junctions

(2016) Magdalene Michael et al.   DEVELOPMENTAL CELL

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Diverse Regulation of Claudin-1 and Claudin-4 in Atopic Dermatitis

(2015) Robert Gruber et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanics and dynamics of reconstituted cytoskeletal systems

(2015) Mikkel H. Jensen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

(2015) Selwin K Wu et al.   CELL CYCLE

Tug of war—The influence of opposing physical forces on epithelial cell morphology

(2015) Yanlan Mao et al.   DEVELOPMENTAL BIOLOGY

Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption

(2014) Kaelyn Sumigray et al.   PLoS One

Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

(2014) Mei Rosa Ng et al.   eLife

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

(2013) Adi D. Dubash et al.   JOURNAL OF CELL BIOLOGY

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

(2013) Robert M. Harmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice

(2013) Tomoko Sugawara et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis

(2013) Kazue Yoshida et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Occludin Is Involved in Adhesion, Apoptosis, Differentiation and Ca2+-Homeostasis of Human Keratinocytes: Implications for Tumorigenesis

(2013) Susanne Rachow et al.   PLoS One

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

(2013) A. F. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin Barrier Disruption: A Requirement for Allergen Sensitization?

(2012) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium

(2012) Kaelyn D. Sumigray et al.   MOLECULAR BIOLOGY OF THE CELL

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding

(2012) Eliana Marinari et al.   NATURE

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Ligand Targeting of EphA2 Enhances Keratinocyte Adhesion and Differentiation via Desmoglein 1

(2010) Samantha Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

(2009) Spiro Getsios et al.   JOURNAL OF CELL BIOLOGY

c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential

(2009) R. Marcotte et al.   MOLECULAR AND CELLULAR BIOLOGY

Skin barrier function

(2008) Peter M. Elias   CURRENT ALLERGY AND ASTHMA REPORTS