A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex

Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

(2020) Yajuan Guo et al.   eLife

Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders

(2019) Marina Spörrer et al.   EBioMedicine

Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin through amphiregulin–epidermal growth factor receptor signaling

(2019) Andrea Scheffschick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration

(2017) Vitali Alexeev et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models

(2017) Jos P. H. Smits et al.   Scientific Reports

Progress towards a public chemogenomic set for protein kinases and a call for contributions

(2017) David H. Drewry et al.   PLoS One

Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease

(2016) Vinod Kumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reduction in keratin aggregates in epidermolysis bullosa simplex keratinocytes after pretreatment with trimethylamine N-oxide

(2015) Mbarka Bchetnia et al.   EXPERIMENTAL DERMATOLOGY

PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding

(2015) Raymond Kwan et al.   HEPATOLOGY

Proinflammatory Cytokines and Antiskin Autoantibodies in Patients With Inherited Epidermolysis Bullosa

(2015) Giuseppina Annicchiarico et al.   MEDICINE

Comprehensive characterization of the Published Kinase Inhibitor Set

(2015) Jonathan M Elkins et al.   NATURE BIOTECHNOLOGY

Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

(2014) David Drewry et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor

(2013) Miroslav Blumenberg   BMC GENOMICS

Imbalance of intermediate filament component keratin 14 contributes to increased stress signalling in epidermolysis bullosa simplex

(2013) Martin Wagner et al.   EXPERIMENTAL DERMATOLOGY

Dermatologic adverse events associated with afatinib: an oral ErbB family blocker

(2013) Mario E Lacouture et al.   Expert Review of Anticancer Therapy

The Pathogenetic Role of IL-1β in Severe Epidermolysis Bullosa Simplex

(2013) Verena Wally et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

YAP and TAZ Regulate Skin Wound Healing

(2013) Min-Jung Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex

(2013) Thomas Lettner et al.   PLoS One

Measuring the regulation of keratin filament network dynamics

(2013) M. Moch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratinocyte-based cell assays: their potential pitfalls

(2012) Tina Zupancic et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Monitoring the Cytoskeletal EGF Response in Live Gastric Carcinoma Cells

(2012) Marco Felkl et al.   PLoS One

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

(2011) Reinhard Windoffer et al.   JOURNAL OF CELL BIOLOGY

Chemical Chaperones Protect Epidermolysis Bullosa Simplex Keratinocytes from Heat Stress–Induced Keratin Aggregation: Involvement of Heat Shock Proteins and MAP Kinases

(2011) Jean Christopher Chamcheu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratin 14-Null Cells as a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells

(2011) Mariella D'Alessandro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a usefulin vitromodel for testing new treatments

(2010) J.C. Chamcheu et al.   BRITISH JOURNAL OF DERMATOLOGY

Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes

(2009) Mirjana Liovic et al.   EXPERIMENTAL CELL RESEARCH

Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: Trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

(2009) Jean Christopher Chamcheu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

ERK Involvement in Resistance to Apoptosis in Keratinocytes with Mutant Keratin

(2009) David Russell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

(2008) Mirjana Liovic et al.   EXPERIMENTAL CELL RESEARCH

Automated Protein Distribution Detection in High-Throughput Image-Based siRNA Library Screens

(2008) Yan Nei Law et al.   Journal of Signal Processing Systems for Signal Image and Video Technology