The barrier and beyond: Roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome

(2021) Malte Christoph Rühlemann et al.   NATURE GENETICS

Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis

(2021) Pengfei Xu et al.   GASTROENTEROLOGY

Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans

(2021) Caroline A. Werlang et al.   Nature Microbiology

A single sulfatase is required to access colonic mucin by a gut bacterium

(2021) Ana S. Luis et al.   NATURE

Mutual regulation between butyrate and HIF‐1α in epithelial cell promotes expression of Tight Junction (TJ) proteins

(2020) Jiuheng Yin et al.   CELL BIOLOGY INTERNATIONAL

Novel methods in glycomics: a 2019 update

(2020) Wei-Qian Cao et al.   Expert Review of Proteomics

Mucins and the Microbiome

(2020) Gunnar C. Hansson   Annual Review of Biochemistry

Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum

(2020) Shingo Hino et al.   JOURNAL OF NUTRITION

Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice

(2020) Gregory P. Donaldson et al.   Nature Microbiology

Home, Sweet Home: How Mucus Accommodates our Microbiota

(2020) Benjamin X. Wang et al.   FEBS Journal

Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen

(2020) Kevin Tsai et al.   JOURNAL OF IMMUNOLOGY

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

(2020) Matthew R. Kudelka et al.   Nature Reviews Gastroenterology & Hepatology

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

(2020) Lucy I. Crouch et al.   Nature Communications

Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury

(2020) Aralia Leon-Coria et al.   Cellular and Molecular Gastroenterology and Hepatology

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

(2020) K. M. Pruss et al.   ISME Journal

Forming a mucus barrier along the colon

(2020) George M. H. Birchenough et al.   SCIENCE

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

(2020) Kirk Bergstrom et al.   SCIENCE

Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies

(2020) Jensine A. Grondin et al.   Frontiers in Immunology

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection

(2019) Q. R. Ducarmon et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

(2019) Joana K. Volk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

(2019) Takahiro Yamada et al.   EBioMedicine

The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

(2019) Gareth W. Hughes et al.   Scientific Reports

Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection

(2019) Kelsey M. Wheeler et al.   Nature Microbiology

Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses

(2019) Karen N. Barnard et al.   mBio

Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota

(2018) Carolina Tropini et al.   CELL

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner

(2018) Felipe Melo-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut microbiota utilize immunoglobulin A for mucosal colonization

(2018) G. P. Donaldson et al.   SCIENCE

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A

(2018) June L. Chan et al.   Mucosal Immunology

Mucins trigger dispersal of Pseudomonas aeruginosa biofilms

(2018) Julia Y. Co et al.   npj Biofilms and Microbiomes

Polysaccharide Utilization Loci: Fueling Microbial Communities

(2017) Julie M. Grondin et al.   JOURNAL OF BACTERIOLOGY

The sialateO-acetylesterase EstA from gutBacteroidetesspecies enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans

(2017) Lloyd S. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative microbiome profiling links gut community variation to microbial load

(2017) Doris Vandeputte et al.   NATURE

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

(2017) Daniel C. Propheter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entamoeba histolytica -Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense

(2017) Steve Cornick et al.   mBio

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

(2017) C. David Owen et al.   Nature Communications

Mucus organisation is shaped by colonic content; a new view

(2017) J. B. J. Kamphuis et al.   Scientific Reports

Loss of intestinal O-glycans promotes spontaneous duodenal tumors

(2016) Nan Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sulfatases and radical SAM enzymes: emerging themes in glycosaminoglycan metabolism and the human microbiota

(2016) A. Benjdia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism

(2016) Janelle S. Ayres   CELL

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

(2016) Mark R. Charbonneau et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice

(2016) Kirk Bergstrom et al.   GASTROENTEROLOGY

Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

(2016) K Bergstrom et al.   Mucosal Immunology

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

(2016) Ryu Okumura et al.   NATURE

Cosmcis an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk

(2016) Matthew R. Kudelka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

(2016) Joakim H. Bergström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles

(2015) Christina A. Hickey et al.   Cell Host & Microbe

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells

(2015) Jun Ye et al.   DIGESTIVE DISEASES AND SCIENCES

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

(2015) Misagh Alipour et al.   Journal of Crohns & Colitis

Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2

(2015) E R Cobo et al.   Mucosal Immunology

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

(2015) N. A. Pudlo et al.   mBio

9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate

(2015) Anna-Maria T. Baumann et al.   Nature Communications

The outer mucus layer hosts a distinct intestinal microbial niche

(2015) Hai Li et al.   Nature Communications

Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice

(2015) Yen-Lin Huang et al.   Nature Communications

Core 2 mucin-type O-glycan inhibits EPEC or EHEC O157:H7 invasion into HT-29 epithelial cells

(2015) Jun Ye et al.   Gut Pathogens

Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection

(2015) Philipp Rausch et al.   PLoS Pathogens

Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets

(2014) Y. Pan et al.   BLOOD

Structural insights into bacterial recognition of intestinal mucins

(2014) Sabrina Etzold et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism

(2014) Maomeng Tong et al.   ISME Journal

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

(2014) K A Knoop et al.   Mucosal Immunology

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

(2014) Felix Sommer et al.   PLoS One

Spontaneous Colitis in Muc2-Deficient Mice Reflects Clinical and Cellular Features of Active Ulcerative Colitis

(2014) Ulf A. Wenzel et al.   PLoS One

A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection

(2014) Martin Stahl et al.   PLoS Pathogens

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution

(2013) Jessica M. Holmén Larsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Structural basis for adaptation of lactobacilli to gastrointestinal mucus

(2013) Sabrina Etzold et al.   ENVIRONMENTAL MICROBIOLOGY

Mucin-type O-glycans and their roles in intestinal homeostasis

(2013) K. S. B. Bergstrom et al.   GLYCOBIOLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

Human colonic mucus is a reservoir for antimicrobial peptides

(2013) Lena Antoni et al.   Journal of Crohns & Colitis

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

Bacterial colonization factors control specificity and stability of the gut microbiota

(2013) S. Melanie Lee et al.   NATURE

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Milk oligosaccharide sialyl( 2,3)lactose activates intestinal CD11c+ cells through TLR4

(2013) E. Kurakevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

(2013) P. C. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Ulcerative colitis

(2013) A. C. Ford et al.   BMJ-British Medical Journal

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2

(2012) Kristina A Thomsson et al.   GLYCOBIOLOGY

Fucose sensing regulates bacterial intestinal colonization

(2012) Alline R. Pacheco et al.   NATURE

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

How glycan metabolism shapes the human gut microbiota

(2012) Nicole M. Koropatkin et al.   NATURE REVIEWS MICROBIOLOGY

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Defense and Adaptation: The Complex Inter-Relationship between Campylobacter jejuni and Mucus

(2012) Abofu Alemka et al.   Frontiers in Cellular and Infection Microbiology

Modifications of Glycans: Biological Significance and Therapeutic Opportunities

(2011) Saddam M. Muthana et al.   ACS Chemical Biology

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

(2011) Seth M. Bloom et al.   Cell Host & Microbe

Composition and functional role of the mucus layers in the intestine

(2011) Malin E. V. Johansson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

L-Fucose utilization provides Campylobacter jejuni with a competitive advantage

(2011) M. Stahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Butyrate enemas do not affect human colonic MUC2 and TFF3 expression

(2010) Henrike M. Hamer et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

(2010) Dermot P.B. McGovern et al.   HUMAN MOLECULAR GENETICS

Probiotic Colonization of the Adherent Mucus Layer of HT29MTXE12 Cells Attenuates Campylobacter jejuni Virulence Properties

(2010) A. Alemka et al.   INFECTION AND IMMUNITY

Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization

(2010) Andrea Fuhrer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro

(2010) A. Alemka et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

Host Tolerance versus Resistance and Microbial Virulence in the Host-Pathogen Equation

(2009) Dominique Ferrandon   Cell Host & Microbe

Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa

(2009) Ana Magalhães et al.   GLYCOBIOLOGY

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

(2009) P A Dawson et al.   GUT

Sulfation of Colonic Mucins byN-Acetylglucosamine 6-O-Sulfotransferase-2 and Its Protective Function in Experimental Colitis in Mice

(2009) Yuki Tobisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

(2009) Malin E. V. Johansson et al.   JOURNAL OF PROTEOME RESEARCH

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Damage control in host-pathogen interactions

(2009) R. Medzhitov   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biostructure of Fecal Microbiota in Healthy Subjects and Patients With Chronic Idiopathic Diarrhea

(2008) Alexander Swidsinski et al.   GASTROENTEROLOGY

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

Intestinal Adherence of Vibrio cholerae Involves a Coordinated Interaction between Colonization Factor GbpA and Mucin

(2008) R. Bhowmick et al.   INFECTION AND IMMUNITY

Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants

(2008) Q. V. Tu et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Infection byHelicobacter pyloriexpressing the BabA adhesin is influenced by the secretor phenotype

(2008) M Azevedo et al.   JOURNAL OF PATHOLOGY

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection

(2008) Sara Lindén et al.   PLoS Pathogens

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE