Bone Cell Senescence: Mechanisms and Perspectives

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

(2013) Valentina Gambino et al.   AGING CELL

MicroRNA-29a Protects Against Glucocorticoid-Induced Bone Loss and Fragility in Rats by Orchestrating Bone Acquisition and Resorption

(2013) Feng-Sheng Wang et al.   ARTHRITIS AND RHEUMATISM

Boning up on autophagy

(2013) Irving M Shapiro et al.   Autophagy

Adipocytes and the Regulation of Bone Remodeling: A Balancing Act

(2013) Mark E. Nuttall et al.   CALCIFIED TISSUE INTERNATIONAL

Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43

(2013) Joseph P. Stains et al.   CALCIFIED TISSUE INTERNATIONAL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Osteoblast–adipocyte lineage plasticity in tissue development, maintenance and pathology

(2013) Agnes D. Berendsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

MicroRNAs in age-related diseases

(2013) Stefanie Dimmeler et al.   EMBO Molecular Medicine

PPARγ forms a bridge between DNA methylation and histone acetylation at the C/EBPα gene promoter to regulate the balance between osteogenesis and adipogenesis of bone marrow stromal cells

(2013) Qing-hua Zhao et al.   FEBS Journal

Histone Demethylase Jmjd3 Regulates Osteoblast Differentiation via Transcription FactorsRunx2and Osterix

(2013) Di Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

(2013) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

(2013) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Channels Protect Osteocytes Against Oxidative Stress-Induced Cell Death

(2013) Rekha Kar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss

(2013) Tanya Zappitelli et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Realizing the potential of gene-based molecular therapies in bone repair

(2013) Laura Rose et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading

(2013) Daichi Morikawa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

(2013) Masashi Honma et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation

(2013) Fei Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

mTORC2 Regulates Mechanically Induced Cytoskeletal Reorganization and Lineage Selection in Marrow-Derived Mesenchymal Stem Cells

(2013) Buer Sen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Targeting integrins to promote bone formation and repair

(2013) Pierre J. Marie   Nature Reviews Endocrinology

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification

(2013) Baisheng Fu et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Concise Review: Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells

(2013) Julianne N. P. Smith et al.   STEM CELLS

Promotion of Osteoblast Differentiation in Mesenchymal Cells Through Cbl-Mediated Control of STAT5 Activity

(2013) François-Xavier Dieudonne et al.   STEM CELLS

MicroRNA-34a Inhibits Osteoblast Differentiation and In Vivo Bone Formation of Human Stromal Stem Cells

(2013) Li Chen et al.   STEM CELLS

E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis

(2013) N Sévère et al.   Cell Death & Disease

Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation

(2013) J Li et al.   Cell Death & Disease

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

(2013) Baohua Liu et al.   Nature Communications

MicroRNA Functions in Osteogenesis and Dysfunctions in Osteoporosis

(2013) Andre J. van Wijnen et al.   Current Osteoporosis Reports

Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway

(2012) Wei Huang et al.   ACTA PHARMACOLOGICA SINICA

Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling

(2012) Zuzana Saidak et al.   AGING CELL

Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging

(2012) Haitao Wang et al.   AGING CELL

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

(2012) Fumio Arai et al.   Annals of the New York Academy of Sciences

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors

(2012) D. Gonzalez-Nieto et al.   BLOOD

Beyond gap junctions: Connexin43 and bone cell signaling

(2012) Lilian I. Plotkin et al.   BONE

Histone deacetylase 3 is required for maintenance of bone mass during aging

(2012) Meghan E. McGee-Lawrence et al.   BONE

Niche science

(2012) Heinrich Jasper et al.   CELL CYCLE

Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

(2012) Baohua Liu et al.   Cell Metabolism

Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs

(2012) Ling Ye et al.   Cell Stem Cell

Hdac-Mediated Control of Endochondral and Intramembranous Ossification

(2012) Jennifer J. Westendorf et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

MicroRNA in Aging: From Discovery to Biology

(2012) Hwa Jin Jung et al.   CURRENT GENOMICS

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

(2012) Jesús Delgado-Calle et al.   Epigenetics

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading

(2012) Shane A Lloyd et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autophagy: A new player in skeletal maintenance?

(2012) Lynne J Hocking et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pharmacological inhibition of PPARγ increases osteoblastogenesis and bone mass in male C57BL/6 mice

(2012) Gustavo Duque et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

(2012) Qian Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The stem cell niche: tissue physiology at a single cell level

(2012) Jonathan Hoggatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-related changes in gap junctional intercellular communication in osteoblastic cells

(2012) Damian C. Genetos et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing

(2012) Alayna E. Loiselle et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

MicroRNA control of bone formation and homeostasis

(2012) Jane B. Lian et al.   Nature Reviews Endocrinology

Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats

(2012) Y. Sun et al.   OSTEOPOROSIS INTERNATIONAL

Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation

(2012) Mehdi Shakibaei et al.   PLoS One

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon Gamma Inhibits Adipogenesis In Vitro and Prevents Marrow Fat Infiltration in Oophorectomized Mice

(2012) Christopher Vidal et al.   STEM CELLS

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Selective autophagy in the maintenance of cellular homeostasis in aging organisms

(2011) Vanessa M. Hubbard et al.   BIOGERONTOLOGY

Bone and the hematopoietic niche: a tale of two stem cells

(2011) P. Bianco   BLOOD

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

(2011) Carl J. DeSelm et al.   DEVELOPMENTAL CELL

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

Osteoblasts in osteoporosis: past, emerging, and future anabolic targets

(2011) Pierre J Marie et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

The role of ubiquitin–proteasome system in ageing

(2011) Peter Löw   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The Casitas B Lineage Lymphoma (Cbl) Mutant G306E Enhances Osteogenic Differentiation in Human Mesenchymal Stromal Cells in Part by Decreased Cbl-mediated Platelet-derived Growth Factor Receptor α and Fibroblast Growth Factor Receptor 2 Ubiquitination

(2011) Nicolas Sévère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forum on aging and skeletal health: Summary of the proceedings of an ASBMR workshop

(2011) Sundeep Khosla et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

(2011) Hamid Saeed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking

(2011) Hidetoshi Nojiri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis

(2011) Pei-Chi Tseng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1

(2011) Tetsuro Yasui et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA methylation contributes to the regulation of sclerostin expression in human osteocytes

(2011) Jesús Delgado-Calle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

(2011) Nicoletta Bivi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Extrinsic Mechanisms Involved in Age-Related Defective Bone Formation

(2011) Pierre J. Marie et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lamin A/C deficiency is associated with fat infiltration of muscle and bone

(2011) Jessica Tong et al.   MECHANISMS OF AGEING AND DEVELOPMENT

MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix

(2011) Jin-fang Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice

(2011) Wei Li et al.   PLoS One

Autophagy in Stem Cell Maintenance and Differentiation

(2011) Alexandre Teixeira Vessoni et al.   STEM CELLS AND DEVELOPMENT

Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy

(2011) Kangkai Wang et al.   Journal of Molecular Cell Biology

Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration

(2010) Robert L. Jilka et al.   AGING CELL

Functions of nuclear factor κB in bone

(2010) Brendan F. Boyce et al.   Annals of the New York Academy of Sciences

Epigenetic Control of Aging

(2010) Ursula Muñoz-Najar et al.   ANTIOXIDANTS & REDOX SIGNALING

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

(2010) Liping Xiao et al.   BONE

Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures

(2010) Ki Hyun Baek et al.   CALCIFIED TISSUE INTERNATIONAL

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

Role of NF-κB in the skeleton

(2010) Deborah Veis Novack   CELL RESEARCH

Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function

(2010) Erin J. Oakley et al.   Cell Stem Cell

Stem Cells and the Niche: A Dynamic Duo

(2010) Justin Voog et al.   Cell Stem Cell

Connecting autophagy to senescence in pathophysiology

(2010) Andrew RJ Young et al.   CURRENT OPINION IN CELL BIOLOGY

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells

(2010) Jennifer R Stevens et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

(2010) Ying-Hua Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage

(2010) Alessandra Gambardella et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

(2010) Eric Hesse et al.   JOURNAL OF CELL BIOLOGY

Aging and Bone

(2010) A.L. Boskey et al.   JOURNAL OF DENTAL RESEARCH

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

(2010) Yongkun Wei et al.   NATURE CELL BIOLOGY

Novel functions for NFκB: inhibition of bone formation

(2010) Susan A. Krum et al.   Nature Reviews Rheumatology

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

(2009) A. Kohler et al.   BLOOD

Genetic and epigenetic regulation of aging

(2009) Mario F Fraga   CURRENT OPINION IN IMMUNOLOGY

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches

(2009) Joy Y Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

What is the true nature of the osteoblastic hematopoietic stem cell niche?

(2009) Maria Askmyr et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation

(2008) Martina Rauner et al.   AGE

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

N-Cadherin Expression Level Distinguishes Reserved versus Primed States of Hematopoietic Stem Cells

(2008) Jeffrey S. Haug et al.   Cell Stem Cell

Inhibition of Lamin A/C Attenuates Osteoblast Differentiation and Enhances RANKL-Dependent Osteoclastogenesis

(2008) Martina Rauner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of Lamin A/C Knockdown on Osteoblast Differentiation and Function

(2008) Rahima Akter et al.   JOURNAL OF BONE AND MINERAL RESEARCH

N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/ -Catenin Signaling, Osteoblast Function, and Bone Formation

(2008) E. Hay et al.   MOLECULAR AND CELLULAR BIOLOGY

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis

(2007) Robert J. Pignolo et al.   AGING CELL