Age-Related Impairment of Bones' Adaptive Response to Loading in Mice Is Associated With Sex-Related Deficiencies in Osteoblasts but No Change in Osteocytes

Replicatively senescent cells are arrested in G1 and G2 phases

(2016) Zhiyong Mao et al.   Aging-US

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

(2013) Lee B. Meakin et al.   BONE

Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt AntagonistSostIs Mediated by Estrogen Receptor β

(2013) Gabriel L. Galea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice

(2013) Tarpit K. Patel et al.   JOURNAL OF BIOMECHANICS

Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton

(2012) Sundar Srinivasan et al.   AGEING RESEARCH REVIEWS

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

(2012) Mohammed-Salleh M Ardawi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

(2012) Toshihiro Sugiyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2

(2012) Sara H Windahl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathogenesis of Age-Related Bone Loss in Humans

(2012) S. Khosla   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response

(2012) Laurent Jullien et al.   NUCLEIC ACIDS RESEARCH

Lrp5 Is Not Required for the Proliferative Response of Osteoblasts to Strain but Regulates Proliferation and Apoptosis in a Cell Autonomous Manner

(2012) Behzad Javaheri et al.   PLoS One

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

(2011) Toshihiro Sugiyama et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Loading-related Regulation of Transcription Factor EGR2/Krox-20 in Bone Cells Is ERK1/2 Protein-mediated and Prostaglandin, Wnt Signaling Pathway-, and Insulin-like Growth Factor-I Axis-dependent

(2011) Gul Zaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

(2011) A. Moustafa et al.   OSTEOPOROSIS INTERNATIONAL

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

(2011) Daisuke Sakai et al.   PLoS One

Comparing histological, vascular and molecular responses associated with woven and lamellar bone formation induced by mechanical loading in the rat ulna

(2010) Jennifer A. McKenzie et al.   BONE

Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice

(2010) Mark D. Willinghamm et al.   CALCIFIED TISSUE INTERNATIONAL

Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading

(2010) Matthew J. Pead et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent

(2010) Deborah Kerr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Aging changes mechanical loading thresholds for bone formation in rats

(2010) Charles H. Turner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression

(2010) Michael D Brodt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reprogramming the pluripotent cell cycle: Restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells

(2010) Prachi N. Ghule et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of a 1-year randomized controlled trial of resistance training on lower limb bone and muscle structure and function in older men

(2010) J. Whiteford et al.   OSTEOPOROSIS INTERNATIONAL

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor α and disuse

(2009) Gul Zaman et al.   BONE

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

(2009) Toshihiro Sugiyama et al.   BONE

The Matricellular Protein Periostin Is Required forSostInhibition and the Anabolic Response to Mechanical Loading and Physical Activity

(2009) Nicolas Bonnet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice

(2008) Toshihiro Sugiyama et al.   BONE